{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:12:35Z","timestamp":1787004755110,"version":"build-2736575974"},"reference-count":36,"publisher":"EDP Sciences","issue":"1-2","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd\u2019hui"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>La maladie de Sj\u00f6gren (SjD) est une maladie auto-immune syst\u00e9mique caract\u00e9ris\u00e9e par une triade de sympt\u00f4mes cl\u00e9s affectant presque tous les patients (s\u00e9cheresse salivaire et lacrymale, douleur et fatigue) et une atteinte syst\u00e9mique extra-glandulaire pouvant toucher un \u00e0 deux tiers des patients. Au cours de la derni\u00e8re d\u00e9cennie, les connaissances sur l\u2019\u00e9pid\u00e9miologie, les crit\u00e8res de classification, l\u2019\u00e9valuation de l\u2019activit\u00e9 syst\u00e9mique et des sympt\u00f4mes pr\u00e9sent\u00e9s par les patients se sont d\u00e9velopp\u00e9s. En outre, les progr\u00e8s r\u00e9alis\u00e9s dans la compr\u00e9hension de la physiopathologie du SjD ont permis d\u2019adopter une approche th\u00e9rapeutique plus cibl\u00e9e. La prise en charge actuelle du SjD s\u2019appuie sur les recommandations th\u00e9rapeutiques de l\u2019EULAR. Mais depuis ces recommandations, de nouveaux m\u00e9dicaments ciblant des voies physiopathologiques sp\u00e9cifiques de la maladie, et essentiellement l\u2019activation du lymphocyte B, ont montr\u00e9 une efficacit\u00e9 dans des essais de phase 2. Dans cette revue, nous r\u00e9sumerons les donn\u00e9es factuelles disponibles sur les traitements syst\u00e9miques, y compris\u00a0: 1. les progr\u00e8s dans l\u2019\u00e9valuation des r\u00e9sultats, 2. les preuves actuelles concernant les traitements de fond cibl\u00e9s et les biom\u00e9dicaments ciblant essentiellement les lymphocytes B, 3. une vue d\u2019ensemble des m\u00e9dicaments prometteurs test\u00e9s dans les \u00e9tudes en cours.<\/jats:p>","DOI":"10.1051\/jbio\/2024003","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:05:13Z","timestamp":1721016313000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Maladie de Sj\u00f6gren\u00a0: de la physiopathologie aux avanc\u00e9es 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