{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:11:33Z","timestamp":1751688693847},"reference-count":35,"publisher":"EDP Sciences","issue":"1-2","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd\u2019hui"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:p>L\u2019interleukine (IL)-17A puis l\u2019IL-17F ont \u00e9t\u00e9 d\u00e9couvertes tour \u00e0 tour pour leur r\u00f4le jou\u00e9 dans les maladies inflammatoires chroniques. Elles ont une homologie de s\u00e9quence d\u2019environ 50\u2009% et partagent le m\u00eame r\u00e9cepteur form\u00e9 des cha\u00eenes IL-17RA et IL-17RC. Si elles ont des effets pro-inflammatoires assez similaires, il existe n\u00e9anmoins quelques diff\u00e9rences selon le type cellulaire consid\u00e9r\u00e9 et selon la pr\u00e9sence ou non de TNF, autre cytokine avec laquelle elles ont une synergie d\u2019action. La troisi\u00e8me variable venant moduler leurs effets r\u00e9side dans les interactions entre cellules immunes et cellules stromales, qui, l\u00e0 encore, varient selon le type de cellules stromales. La mise en \u00e9vidence de leur r\u00f4le dans le psoriasis a notamment conduit au d\u00e9veloppement d\u2019inhibiteurs de l\u2019IL-17A, puis \u00e0 la fois de l\u2019IL-17A et de l\u2019IL-17F et enfin d\u2019un de leurs r\u00e9cepteurs. Ces inhibiteurs sont utilis\u00e9s avec succ\u00e8s dans cette pathologie, et leur indication a \u00e9t\u00e9 \u00e9tendue progressivement au rhumatisme psoriasique et \u00e0 certaines formes de spondylarthrite. Enfin, la r\u00e9cente compr\u00e9hension de l\u2019importance des cellules stromales dans la r\u00e9action inflammatoire chronique permet d\u2019expliquer l\u2019efficacit\u00e9 variable de ces bioth\u00e9rapies dans certaines pathologies.<\/jats:p>","DOI":"10.1051\/jbio\/2024004","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:05:13Z","timestamp":1721030713000},"page":"33-39","source":"Crossref","is-referenced-by-count":1,"title":["IL-17A et IL-17F\u00a0: de la d\u00e9couverte au ciblage th\u00e9rapeutique - Un exemple de m\u00e9decine 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