{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:10Z","timestamp":1785484870975,"version":"3.56.0"},"reference-count":58,"publisher":"EDP Sciences","issue":"1-2","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":211,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologie Aujourd\u2019hui"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:p>L\u2019ob\u00e9sit\u00e9 concerne aujourd\u2019hui pr\u00e8s d\u2019un Fran\u00e7ais sur cinq et sa pr\u00e9valence a plus que doubl\u00e9 depuis 1997. Elle est d\u00e9finie comme une maladie chronique \u00e9volutive, responsable de multiples complications m\u00e9caniques (arthrose, lombalgies, incontinence, reflux gastro-oesophagien), m\u00e9taboliques (diab\u00e8te, st\u00e9atopathie, maladies cardiovasculaires) et psychosociales (anxi\u00e9t\u00e9, d\u00e9pression, stigmatisation), ainsi que d\u2019un sur-risque de nombreux cancers. Une nouvelle d\u00e9finition, \u00e9labor\u00e9e en 2025, distingue l\u2019ob\u00e9sit\u00e9 pr\u00e9clinique de l\u2019ob\u00e9sit\u00e9 clinique en int\u00e9grant l\u2019Indice de Masse Corporelle, les atteintes d\u2019organe et les limitations fonctionnelles, et incite \u00e0 un ph\u00e9notypage fin pour personnaliser la prise en charge. En France, les recommandations de la Haute Autorit\u00e9 de Sant\u00e9 (2022, 2024) structurent un parcours gradu\u00e9 (m\u00e9decin g\u00e9n\u00e9raliste, sp\u00e9cialiste, Centre Sp\u00e9cialis\u00e9 Ob\u00e9sit\u00e9) o\u00f9 l\u2019objectif ne se limite pas au poids mais vise aussi les comorbidit\u00e9s, la qualit\u00e9 de vie et la mobilit\u00e9. La base du traitement reste les modifications du mode de vie (nutrition, activit\u00e9 physique, suivi psychologique) dans une d\u00e9marche d\u2019\u00e9ducation th\u00e9rapeutique. Les agonistes des incr\u00e9tines (GLP 1, GLP 1\/GIP) constituent des traitements m\u00e9dicamenteux efficaces, de seconde intention, permettant en moyenne plus de 10\u2009% de perte de poids et une am\u00e9lioration significative des comorbidit\u00e9s m\u00e9taboliques. Toutefois, leur utilisation est limit\u00e9e par des effets secondaires digestifs fr\u00e9quents, un risque de reprise pond\u00e9rale \u00e0 l\u2019arr\u00eat, de carences micronutritionnelles, de pertes musculaire et osseuse, un co\u00fbt \u00e9lev\u00e9 et une observance souvent faible en vie r\u00e9elle. Ils doivent donc s\u2019int\u00e9grer dans une prise en charge globale et durable, centr\u00e9e sur l\u2019accompagnement nutritionnel, l\u2019activit\u00e9 physique, le soutien psychologique et la pr\u00e9vention des carences, de mani\u00e8re \u00e0 optimiser les b\u00e9n\u00e9fices \u00e0 long terme au-del\u00e0 de la seule r\u00e9duction pond\u00e9rale.<\/jats:p>","DOI":"10.1051\/jbio\/2026002","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:45:18Z","timestamp":1785483918000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Changement dans la prise en charge de l\u2019ob\u00e9sit\u00e9\u00a0: vision du clinicien"],"prefix":"10.1051","volume":"220","author":[{"given":"Emilie","family":"Montastier","sequence":"first","affiliation":[{"name":"Service d\u2019Endocrinologie\u00a0\u2013\u2009Diab\u00e9tologie\u2009\u2013\u00a0Nutrition, H\u00f4pital Rangueil, Centre Sp\u00e9cialis\u00e9 de l\u2019Ob\u00e9sit\u00e9, Occitanie 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