{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:57:12Z","timestamp":1773395832289,"version":"3.50.1"},"reference-count":29,"publisher":"EDP Sciences","issue":"1","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Extra Corpor Technol","JECT"],"accepted":{"date-parts":[[2025,9,2]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"\n Background<\/jats:italic>\n : The accuracy and precision of continuous in-line blood gas monitoring (CILBGM) are crucial for optimal blood gas management during cardiopulmonary bypass (CPB) and improved patient outcomes. CILBGM devices, such as the CDI 500\/550 system, measure PaO\n 2<\/jats:sub>\n and PaCO\n 2,<\/jats:sub>\n and B-Capta measures PaO\n 2<\/jats:sub>\n through direct contact with arterial blood. However, the Quantum perfusion system with Quantum Ventilation\n 2<\/jats:sub>\n (Quantum System) does not measure but calculates PaO\n 2<\/jats:sub>\n and PaCO\n 2<\/jats:sub>\n using several non-invasive sensors and proprietary formulas. We have observed that the calculated in-line PaO\n 2<\/jats:sub>\n and PaCO\n 2<\/jats:sub>\n values from Quantum System are frequently significantly higher than those obtained from iSTAT, a point-of-care blood analyzer, exceeding acceptable targets.\n Methods<\/jats:italic>\n : We conducted a retrospective study involving 81 patients who underwent cardiac surgery using the Quantum System with its own CILBGM and the FX05 oxygenator. The aim was to identify the degree, timing, and possible patterns of error of the calculated in-line PaO\n 2<\/jats:sub>\n and PaCO\n 2<\/jats:sub>\n .\n Results<\/jats:italic>\n : Our study showed that the errors of calculated in-line PaO\n 2<\/jats:sub>\n exceed the acceptable target at the 1st blood gas series and during the rewarming and rewarmed periods, correlating with patient weight. The calculated in-line PaCO\n 2<\/jats:sub>\n exhibited an upward drift during the rewarming period, correlating with the temperature gradient rather than patient weight. Based on several correlations identified, we derived a formula to predict FiO\n 2<\/jats:sub>\n based on patient weight, which would achieve the target PaO\n 2<\/jats:sub>\n \u00a0at the 1st blood gas series when using the FX05 oxygenator.\n Conclusion<\/jats:italic>\n : We identified when and how the errors in calculating in-line PaO\n 2<\/jats:sub>\n and PaCO\n 2<\/jats:sub>\n occurred and developed several recommendations to minimize significant deviations from actual PaO\n 2<\/jats:sub>\n and PaCO\n 2<\/jats:sub>\n during CPB. Our results suggest that achieving acceptable PaO\n 2<\/jats:sub>\n and PaCO\n 2<\/jats:sub>\n calculations throughout CPB using a single universal formula for each, embedded in the Quantum System, is challenging due to the variety of oxygenators available, different patient sizes, and changing conditions during CPB.\n <\/jats:p>","DOI":"10.1051\/ject\/2025051","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T18:45:16Z","timestamp":1757357116000},"page":"43-50","source":"Crossref","is-referenced-by-count":0,"title":["Is continuous in-line blood gas monitoring reliable during cardiopulmonary bypass when PaO\n 2<\/sub>\n and PaCO\n 2<\/sub>\n are calculated rather than measured?"],"prefix":"10.1051","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9579-1284","authenticated-orcid":false,"given":"Min-Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Perfusion Services, Children\u2019s Hospital of Philadelphia","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Perfusion Services, Children\u2019s Hospital of Philadelphia","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/026765919801300105","volume":"13","author":"Stammers","year":"1998","journal-title":"Perfusion"},{"key":"R2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1051\/ject\/1998304166","volume":"30","author":"Southworth","year":"1998","journal-title":"J Extra Corpor Technol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1051\/ject\/2000323120","volume":"32","author":"Trowbridge","year":"2000","journal-title":"J Extra Corpor 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