{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:07:17Z","timestamp":1789474037868,"version":"build-2803163510"},"reference-count":15,"publisher":"EDP Sciences","issue":"3","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Extra Corpor Technol","JECT"],"accepted":{"date-parts":[[2026,2,24]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : Adenosine is a vital medication in cardiac surgery, particularly in valvular heart procedures. While its use has been linked to improved postoperative cardiac function in some studies, there remains significant uncertainty regarding the adenosine usage in aortic reperfusion phase. This lack of consensus poses challenges for surgeons, perfusionists, and anesthesiologists alike. This study aims to explore the impact of adenosine on clinical outcomes in patients undergoing valvular heart surgery.\n                    <jats:italic>Method<\/jats:italic>\n                    : This prospective randomized controlled trial was conducted over a three-month period. Sixty patients undergoing valvular heart surgery were enrolled using a continuous sampling method and randomly allocated into two equal groups of 30 patients each. The intervention group received adenosine-enriched aortic root reperfusion immediately prior to aortic declamping, while the control group underwent standard warm blood aortic root reperfusion. Both groups were matched for demographic and clinical characteristics to ensure comparability.\n                    <jats:italic>Results<\/jats:italic>\n                    : Results indicated no significant differences in mean cardiopulmonary bypass (CPB) time, aortic cross-clamping duration, or mechanical ventilation between the intervention and control groups. However, the intervention group that received adenosine had a higher rate of antiarrhythmic agent usage in the operating room (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Inotropic agent usage was similar in both groups during surgery and in the ICU. Additionally, laboratory parameters on the first day of ICU admission were comparable between groups.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Results in the control group showed more favorable outcomes in terms of anti-arrhythmic drug usage, electroshock application, and arrhythmia prevalence. This study showed advantages for the standard warm blood aortic root reperfusion technique in managing post-operative cardiac rhythm disturbances, in comparison with the trial group.\n                  <\/jats:p>","DOI":"10.1051\/ject\/2026006","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T18:45:26Z","timestamp":1775414726000},"page":"217-222","source":"Crossref","is-referenced-by-count":0,"title":["Impact of adenosine in controlled aortic root reperfusion on clinical outcomes among patients undergoing valvular heart surgery"],"prefix":"10.1051","volume":"58","author":[{"given":"Farshad","family":"Jalili Shahandashti","sequence":"first","affiliation":[{"name":"Rajaie Cardiovascular, Medical and Research Center","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naser","family":"Kachoueian","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Fattahi","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular, Medical and Research Center","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davoud","family":"Samaie","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular, Medical and Research Center","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghanbari Garekani","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular, Medical and Research Center","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Taherkhani","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular, Medical and Research Center","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedehmasoumeh","family":"Seyedebrahimi","sequence":"additional","affiliation":[{"name":"Department of Allied Medicine, Babol University of Medical Sciences","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saied","family":"Heydari Nia","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular, Medical and Research Center","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Gorjipour","sequence":"additional","affiliation":[{"name":"Rajaie Cardiovascular, Medical and Research Center","place":["Iran"]},{"name":"SUNY Upstate Medical University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3270-8487","authenticated-orcid":false,"given":"Fazel","family":"Gorjipour","sequence":"additional","affiliation":[{"name":"Iran University of Medical Sciences","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"R1","unstructured":"Wellons HA, Zacour RK. Cardiopulmonary bypass. Mastery of Cardiothoracic Surgery. 2007:305."},{"issue":"2","key":"R2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0003-4975(99)01325-9","volume":"69","author":"Edwards","year":"2000","journal-title":"Ann Thoracic Surg"},{"issue":"3","key":"R3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jescts.2017.07.005","volume":"25","author":"Elgariah","year":"2017","journal-title":"J Egypt Soc Cardio-Thorac Surg"},{"issue":"2","key":"R4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/021849230601400211","volume":"14","author":"Rergkliang","year":"2006","journal-title":"Asian Cardiovasc Thoracic Ann"},{"issue":"3","key":"R5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-5223(00)70143-7","volume":"119","author":"Fogelson","year":"2000","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"R6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-7120-7-52","volume":"7","author":"Sadigh","year":"2009","journal-title":"Cardiovasc Ultrasound"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Jiang P, Hakim MA, Delkhosh AS, Ahmadi P, Li Y, Mechref Y. 4-plex quantitative glycoproteomics using glycan\/protein-stable isotope labeling in cell culture. J Proteomics 2024:105333.","DOI":"10.1016\/j.jprot.2024.105333"},{"key":"R8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jchromb.2011.12.006","volume":"885","author":"Hui","year":"2012","journal-title":"J Chromatogr B"},{"issue":"2","key":"R9","first-page":"82","volume":"7","author":"Baharestani","year":"2012","journal-title":"J Tehran Heart Cent."},{"key":"R10","unstructured":"Givtaj N. Assessment of protective effects of warm terminal blood cardioplegia on myocardial protection in CABG. Multidiscip Cardiovasc Ann 2009;2(4)."},{"key":"R11","first-page":"299","volume":"9","author":"Kalita","year":"2009","journal-title":"Indian Pacing Electrophysiol J"},{"issue":"6","key":"R12","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1053\/j.jvca.2017.10.041","volume":"32","author":"Ammar","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R13","unstructured":"Ayman Sallam M, Elasfar A, Mohammed Al Assal M, Amro Serag M. Terminal hot shot cardioplegia before removing the cross clamp improves the immediate outcome in high risk patients undergoing coronary artery bypass grafting; single center experience HMJ. 2013;7(1)."},{"issue":"2","key":"R14","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.athoracsur.2007.08.039","volume":"85","author":"Ascione","year":"2008","journal-title":"Ann Thoracic Surg"},{"issue":"6","key":"R15","first-page":"299","volume":"9","author":"Khairy","year":"2009","journal-title":"Indian Pacing Electrophysiol J"}],"container-title":["The Journal of ExtraCorporeal Technology"],"original-title":[],"link":[{"URL":"https:\/\/ject.edpsciences.org\/10.1051\/ject\/2026006\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:46:07Z","timestamp":1789472767000},"score":1,"resource":{"primary":{"URL":"https:\/\/ject.edpsciences.org\/10.1051\/ject\/2026006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":15,"journal-issue":{"issue":"3"},"alternative-id":["ject240055"],"URL":"https:\/\/doi.org\/10.1051\/ject\/2026006","relation":{},"ISSN":["0022-1058","2969-8960"],"issn-type":[{"value":"0022-1058","type":"print"},{"value":"2969-8960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}