{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:06:56Z","timestamp":1789474016271,"version":"build-2803163510"},"reference-count":17,"publisher":"EDP Sciences","issue":"3","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Extra Corpor Technol","JECT"],"accepted":{"date-parts":[[2026,5,18]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : Dosing albumin to normalize colloid osmotic pressure is an underutilized strategy within the application of cardiopulmonary bypass. The negative sequelae of third-spacing and edema post-bypass are well known and documented within the literature, yet it is not common practice for perfusionists to calculate albumin dilution or tailor albumin administration to each individual patient.\n                    <jats:italic>Methods<\/jats:italic>\n                    : The author explored relevant literature to justify quantifying albumin dosing and concentration within the application of cardiopulmonary bypass. Sequelae following edema in the cardiac patient were also explored and presented, justifying the investigation of this topic. Formulas to quantify albumin dilution, resultant drop in colloid osmotic pressure, and suggested albumin dosing, were presented and unified into a model.\n                    <jats:italic>Results<\/jats:italic>\n                    : A spreadsheet-based model was developed to quantify albumin dilution that may be accessed or recreated by the reader for information purposes or for clinical use. This model enables the user to solely quantify their albumin dilution during bypass, or more proactively calculate albumin concentration and dosing in an attempt to mitigate large colloid osmotic pressure changes during bypass.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : Intentional albumin management can yield more physiologically normal albumin concentrations and colloid osmotic pressures undergoing cardiopulmonary bypass, reducing the sequelae previously described. The model presented enables informed albumin dosing by the perfusionist, and use of this model may be of especially great benefit to patients who are hypovolemic, underweight, or pediatric.\n                  <\/jats:p>","DOI":"10.1051\/ject\/2026016","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T18:46:52Z","timestamp":1779562012000},"page":"223-227","source":"Crossref","is-referenced-by-count":0,"title":["A predictive model for prudent albumin priming in cardiopulmonary bypass circuits"],"prefix":"10.1051","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-5110","authenticated-orcid":false,"given":"Julie","family":"Fenske","sequence":"first","affiliation":[{"name":"University of Southern California","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Centner","sequence":"additional","affiliation":[{"name":"University of Southern California","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"R1","unstructured":"Hall JE, Hall ME. Guyton and Hall Textbook of Medical Physiology. 15th ed. Philadelphia Elsevier; 2025."},{"issue":"1","key":"R2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13613-025-01595-0","volume":"15","author":"Magder","year":"2025","journal-title":"Ann Intensive Care"},{"key":"R3","unstructured":"Darwish A, Lui F. Physiology, colloid osmotic pressure. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 [cited 2026 Feb 24]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK541067\/"},{"issue":"1","key":"R4","first-page":"1","volume":"2","author":"Scallan","year":"2010","journal-title":"Colloq Ser Integr Syst Physiol"},{"issue":"2","key":"R5","doi-asserted-by":"crossref","first-page":"ezae354","DOI":"10.1093\/ejcts\/ezae354","volume":"67","author":"Wahba","year":"2025","journal-title":"Eur J Cardiothorac Surg"},{"issue":"2","key":"R6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.athoracsur.2016.02.005","volume":"102","author":"Elvevoll","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Thorup L, Dehn AM, Heiberg J, et al. Reduced lymphatic activity during positive pressure ventilation and general anesthesia\u2014a cause of postoperative edema? Acta Anaesthesiol Scand. 2025;69(6).","DOI":"10.1111\/aas.70066"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Dekker NA, Leeuwen AL, Strien WW, et al. Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels. Crit Care. 2019;23(1).","DOI":"10.1186\/s13054-019-2418-5"},{"issue":"5","key":"R9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/bja\/aer269","volume":"107","author":"Annecke","year":"2011","journal-title":"Br J Anaesth."},{"issue":"6","key":"R10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/jcdd10060263","volume":"10","author":"Kr\u00fcger","year":"2023","journal-title":"J Cardiovasc Dev Dis."},{"issue":"6","key":"R11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00467-020-04489-4","volume":"35","author":"Bellos","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Xu J, Shen B, Fang Y, et al. Postoperative fluid overload is a useful predictor of short-term outcome of renal replacement therapy for acute kidney injury after cardiac surgery. Medicine (Baltimore). 2015;94(33).","DOI":"10.1097\/MD.0000000000001360"},{"key":"R13","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.xjon.2023.10.017","volume":"16","author":"Koskinen","year":"2023","journal-title":"JTCVS Open"},{"issue":"2","key":"R14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4236\/wjcs.2011.12004","volume":"1","author":"Morin","year":"2011","journal-title":"World J Cardiovasc Surg"},{"key":"R15","unstructured":"Landis EM, Pappenheimer JR. Exchange of substances through the capillary walls. In: Handbook of Physiology. Section 2: Circulation. Washington (DC): American Physiological Society; 1963. p. 961-1043."},{"issue":"1","key":"R16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1620\/tjem.135.43","volume":"135","author":"Nitta","year":"1981","journal-title":"Tohoku J Exp Med"},{"issue":"2","key":"R17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/026765910101600207","volume":"16","author":"Zarro","year":"2001","journal-title":"Perfusion"}],"container-title":["The Journal of ExtraCorporeal Technology"],"original-title":[],"link":[{"URL":"https:\/\/ject.edpsciences.org\/10.1051\/ject\/2026016\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:46:14Z","timestamp":1789472774000},"score":1,"resource":{"primary":{"URL":"https:\/\/ject.edpsciences.org\/10.1051\/ject\/2026016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":17,"journal-issue":{"issue":"3"},"alternative-id":["ject260012"],"URL":"https:\/\/doi.org\/10.1051\/ject\/2026016","relation":{},"ISSN":["0022-1058","2969-8960"],"issn-type":[{"value":"0022-1058","type":"print"},{"value":"2969-8960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}