{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:07:24Z","timestamp":1789474044417,"version":"build-2803163510"},"reference-count":145,"publisher":"EDP Sciences","issue":"3","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"American Heart Association Innovative Project Award","award":["24IPA1275689"],"award-info":[{"award-number":["24IPA1275689"]}]},{"name":"Stony Brook University VDR Fusion Grant","award":["JS 2024"],"award-info":[{"award-number":["JS 2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Extra Corpor Technol","JECT"],"accepted":{"date-parts":[[2026,5,24]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Extracorporeal membrane oxygenation (ECMO) provides heart\/lung support for critically ill patients. While advances in research have improved the overall design and performance of ECMO circuits, complications such as hemolysis and thrombosis persist, and the dysfunction of the ECMO machine itself can pose significant risk to patients. Many parameters need to be closely monitored during an ECMO run, and it is often labor and resource-intensive. Currently, there are few commercially available automated ECMO circuit monitoring systems that can provide continuous, holistic monitoring for ECMO circuit health and provide real-time clinical recommendations.<\/jats:p>\n                  <jats:p>This mixed-methods review (through literature review and customer discovery interviews) discussed key parameters relevant to ECMO circuits and monitoring, including bleeding, thrombosis, hemolysis, flow and pressure conditions, and gas exchange. Their importance in ECMO monitoring, current practices, and available technologies were highlighted. In addition, a customer discovery study, supported by the New York regional I-Corps program, was conducted to identify the \u201cpain points\u201d in ECMO circuit monitoring through interviews with healthcare professionals and other stakeholders experienced in ECMO care\/use.<\/jats:p>\n                  <jats:p>Findings from both the literature review and the customer discovery study indicated that ECMO monitoring and management require significant resources, due to the variability and complexity of patients\u2019 conditions, challenges in collecting patient and ECMO circuit data, and the need for a comprehensive understanding of the entire patient-ECMO ecosystem. Improvements in understanding complex ECMO data, incorporating new sensors into the monitoring system, and establishing comprehensive ECMO data pipelines represent key steps towards developing \u201csmart\u201d ECMO monitoring that can serve as a clinical decision support system.<\/jats:p>","DOI":"10.1051\/ject\/2026022","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:44:41Z","timestamp":1780080281000},"page":"280-294","source":"Crossref","is-referenced-by-count":0,"title":["Challenges and opportunities in ECMO monitoring: A mixed-methods appraisal"],"prefix":"10.1051","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-0375","authenticated-orcid":false,"given":"Wei","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Permessur","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Pittas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiffoni","family":"Sukhlal","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cobos","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Sabetta","sequence":"additional","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Cahill","sequence":"additional","affiliation":[{"name":"Cardiovascular Perfusion Division, Department of Cardiac Surgery, Renaissance School of Medicine, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Longtin","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"R1","unstructured":"ELSO live registry dashboard of ECMO patient data. Registry dashboard ECMO."},{"issue":"12","key":"R2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1056\/nejm197203232861204","volume":"286","author":"Hill","year":"1972","journal-title":"N Engl J Med."},{"issue":"3","key":"R3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0022-5223(19)39916-7","volume":"73","author":"Bartlett","year":"1977","journal-title":"J Thorac Cardiovasc Surg."},{"key":"R4","doi-asserted-by":"crossref","unstructured":"The ECMO circuit. In: Vuylsteke A, Brodie D, Combes A, Fowles J-a, Peek G, editors. ECMO in the Adult Patient. Cambridge: Cambridge University Press; 2017; 25\u201357.","DOI":"10.1017\/9781139088251.004"},{"issue":"1","key":"R5","doi-asserted-by":"publisher","first-page":"19275","DOI":"10.1038\/s41598-020-76299-5","volume":"10","author":"Lindberg","year":"2020","journal-title":"Scientific Reports."},{"key":"R6","doi-asserted-by":"publisher","first-page":"832776","DOI":"10.3389\/fped.2022.832776","volume":"10","author":"Cui","year":"2022","journal-title":"Front Pediatr."},{"issue":"24","key":"R7","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1001\/jama.2020.9148","volume":"323","author":"Hadaya","year":"2020","journal-title":"Jama."},{"issue":"(1)","key":"R8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.hlc.2013.08.009","volume":"23","author":"Laf\u00e7","year":"2014","journal-title":"Heart Lung Circ."},{"issue":"(Suppl 2)","key":"R9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s12055-020-00999-w","volume":"37","author":"Pooboni","year":"2021","journal-title":"Indian J Thorac Cardiovasc Surg."},{"key":"R10","unstructured":"Vyas A, Bishop MA. Extracorporeal Membrane Oxygenation in Adults. StatPearls. Treasure Island (FL): StatPearls Publishing. Copyright \u00a9 2024, StatPearls Publishing LLC.; 2024."},{"issue":"11","key":"R11","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1111\/j.1525-1594.2009.00955.x","volume":"33","author":"Guan","year":"2009","journal-title":"Artif Organs."},{"issue":"3","key":"R12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1051\/ject\/200941172","volume":"41","author":"Sutton","year":"2009","journal-title":"J Extra Corpor Technol."},{"key":"R13","unstructured":"Farkas J. ECMO manual. The internet book of critical care2025."},{"key":"R14","unstructured":"Patient and ECMO monitoring The Alfred Part of Alfred Health. Available from: https:\/\/ecmo.icu\/daily-care-nursing-routine-patient-and-ecmo-monitoring\/?form=MG0AV3."},{"issue":"7","key":"R15","doi-asserted-by":"publisher","first-page":"E166","DOI":"10.3978\/j.issn.2072-1439.2015.07.17","volume":"7","author":"Makdisi","year":"2015","journal-title":"J Thorac Dis."},{"key":"R16","doi-asserted-by":"publisher","unstructured":"Chen Z, Liang N, Zhang H, et al. Harnessing the power of clinical decision support systems: challenges and opportunities. Open Heart. 2023;10(2). Epub 20231128. https:\/\/doi.org\/10.1136\/openhrt-2023-002432. PubMed PMID: 38016787; PMCID: PMC10685930.","DOI":"10.1136\/openhrt-2023-002432"},{"issue":"(9)","key":"R17","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1136\/bmjqs-2018-008765","volume":"28","author":"Downing","year":"2019","journal-title":"BMJ Qual Saf."},{"issue":"3","key":"R18","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/aln.0000000000003385","volume":"133","author":"Ruskin","year":"2020","journal-title":"Anesthesiology."},{"issue":"3","key":"R19","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1177\/0018720810376055","volume":"52","author":"Parasuraman","year":"2010","journal-title":"Hum Factors."},{"issue":"1","key":"R20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1051\/ject\/2023047","volume":"56","author":"Butt","year":"2024","journal-title":"J Extra Corpor Technol."},{"issue":"2","key":"R21","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1097\/aln.0000000000003014","volume":"132","author":"Joosten","year":"2020","journal-title":"Anesthesiology."},{"issue":"3","key":"R22","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/aln.0000000000001892","volume":"128","author":"Lee","year":"2018","journal-title":"Anesthesiology."},{"key":"R23","unstructured":"Maquet Cardiohelp System Soma Tech Intl. Available from: https:\/\/www.somatechnology.com\/wp-content\/uploads\/2026\/04\/Maquet-Cardiohelp-System-ECMO-Machine.pdf."},{"key":"R24","doi-asserted-by":"publisher","unstructured":"Mossadegh C. Monitoring the ECMO. Nursing Care and ECMO. 2016:45\u201370. Epub 20161110. https:\/\/doi.org\/10.1007\/978-3-319-20101-6_5; PMCID: PMC7123851.","DOI":"10.1007\/978-3-319-20101-6_5"},{"key":"R25","unstructured":"About I-Corps U.S. National Science Foundation [cited 2025]. Available from: https:\/\/new.nsf.gov\/funding\/initiatives\/i-corps\/about-i-corps."},{"key":"R26","doi-asserted-by":"publisher","first-page":"5348835","DOI":"10.1155\/2022\/5348835","volume":"2022","author":"Nguyen","year":"2022","journal-title":"Crit Care Res Pract."},{"issue":"(Suppl 2)","key":"R27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s12055-021-01176-3","volume":"37","author":"Kumar","year":"2021","journal-title":"Indian J Thorac Cardiovasc Surg."},{"issue":"(1)","key":"R28","doi-asserted-by":"publisher","first-page":"14557","DOI":"10.1038\/s41598-023-41773-3","volume":"13","author":"Hvas","year":"2023","journal-title":"Sci Rep."},{"key":"R29","doi-asserted-by":"publisher","first-page":"879579","DOI":"10.3389\/fmed.2022.879579","volume":"9","author":"Kalbhenn","year":"2022","journal-title":"Front Med (Lausanne)."},{"issue":"(2)","key":"R30","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.athoracsur.2020.02.012","volume":"111","author":"Ellouze","year":"2021","journal-title":"Ann Thorac Surg."},{"key":"R31","doi-asserted-by":"publisher","unstructured":"Vaquer S, de Haro C, Peruga P, Oliva JC, Artigas A. Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome. Ann Intensive Care. 2017;7(1):51. Epub 20170512. https:\/\/doi.org\/10.1186\/s13613-017-0275-4. PubMed PMID: 28500585; PMCID: PMC5429319.","DOI":"10.1186\/s13613-017-0275-4"},{"issue":"15","key":"R32","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1001\/jama.2011.1471","volume":"306","author":"Noah","year":"2011","journal-title":"Jama."},{"issue":"4","key":"R33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.21037\/atm.2016.11.47","volume":"5","author":"Pavlushkov","year":"2017","journal-title":"Ann Transl Med."},{"issue":"2","key":"R34","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jvs.2020.05.071","volume":"73","author":"Son","year":"2021","journal-title":"J Vascu Surg."},{"issue":"3","key":"R35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/MAT.0000000000001230","volume":"67","author":"Olson","year":"2021","journal-title":"ASAIO J."},{"issue":"6","key":"R36","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1213\/ANE.0b013e3182354b7e","volume":"113","author":"Sniecinski","year":"2011","journal-title":"Anesth Analg."},{"issue":"(8)","key":"R37","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1039\/c6bm00271d","volume":"4","author":"Wo","year":"2016","journal-title":"Biomater Sci."},{"issue":"8","key":"R38","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1097\/MAT.0000000000001605","volume":"68","author":"Figueroa Villalba","year":"2022","journal-title":"ASAIO J."},{"issue":"1","key":"R39","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13054-023-04433-6","volume":"27","author":"Taccone","year":"2023","journal-title":"Critical Care."},{"issue":"(9)","key":"R40","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1111\/jth.15784","volume":"20","author":"Staessens","year":"2022","journal-title":"J Thromb Haemost."},{"issue":"6","key":"R41","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1097\/mat.0000000000000133","volume":"60","author":"Dornia","year":"2014","journal-title":"Asaio j."},{"issue":"(1)","key":"R42","doi-asserted-by":"publisher","first-page":"10438","DOI":"10.1038\/s41598-024-59873-z","volume":"14","author":"Rim","year":"2024","journal-title":"Sci Rep."},{"issue":"1","key":"R43","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12959-023-00452-z","volume":"21","author":"Zeibi Shirejini","year":"2023","journal-title":"Thrombosis J."},{"key":"R44","doi-asserted-by":"publisher","first-page":"887199","DOI":"10.3389\/fmed.2022.887199","volume":"9","author":"Neunert","year":"2022","journal-title":"Front Med (Lausanne)."},{"key":"R45","unstructured":"K\u0131rali K, Altinay E, O\u011fu\u015f H. Anticoagulation strategies during ECMO application. In: Firstenberg MS, ed. Evolving Therapies and Technologies in Extracorporeal Membrane Oxygenation. Rijeka: IntechOpen; 2024."},{"issue":"(18)","key":"R46","doi-asserted-by":"publisher","first-page":"6067","DOI":"10.3390\/jcm12186067","volume":"12","author":"\u0160olt\u00e9s","year":"2023","journal-title":"J Clin Med."},{"key":"R47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13017-015-0006-9","volume":"10","author":"Wen","year":"2015","journal-title":"World J Emerg Surg."},{"issue":"(1)","key":"R48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2049-6958-8-16","volume":"8","author":"Lee","year":"2013","journal-title":"Multidiscip Respir Med."},{"issue":"6","key":"R49","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1177\/026765919901400612","volume":"14","author":"Reynolds","year":"1999","journal-title":"Perfusion."},{"issue":"5","key":"R50","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.21037\/jtd.2020.04.54","volume":"12","author":"Fina","year":"2020","journal-title":"J Thorac Dis."},{"key":"R51","doi-asserted-by":"publisher","first-page":"884063","DOI":"10.3389\/fcvm.2022.884063","volume":"9","author":"De Paulis","year":"2022","journal-title":"Front Cardiovasc Med."},{"issue":"4","key":"R52","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1164\/rccm.202305-0896OC","volume":"209","author":"Martucci","year":"2024","journal-title":"Am J Respir Crit Care Med."},{"key":"R53","unstructured":"Zaidi SRH, Rout P. Interpretation of Blood Clotting Studies and Values (PT, PTT, aPTT, INR, Anti-Factor Xa, D-Dimer). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024."},{"issue":"9","key":"R54","first-page":"782","volume":"122","author":"Olson","year":"1998","journal-title":"Arch Pathol Lab Med."},{"issue":"1","key":"R55","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1365-2141.2005.05953.x","volume":"133","author":"Baglin","year":"2006","journal-title":"Br J Haematol."},{"issue":"1","key":"R56","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12959-021-00280-z","volume":"19","author":"Ogawa","year":"2021","journal-title":"Thrombosis J."},{"key":"R57","doi-asserted-by":"crossref","unstructured":"Bembea MM, Annich G, Rycus P, Oldenburg G, Berkowitz I, Pronovost P. Variability in anticoagulation management of patients on extracorporeal membrane oxygenation: An international survey*. Pediatri Crit Care Med. 2013;14(2).","DOI":"10.1097\/PCC.0b013e31827127e4"},{"issue":"(3)","key":"R58","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/ijlh.13780","volume":"44","author":"Teruya","year":"2022","journal-title":"Int J Lab Hematol."},{"issue":"9","key":"R59","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1111\/aor.12460","volume":"39","author":"Dornia","year":"2015","journal-title":"Artif Organs."},{"key":"R60","doi-asserted-by":"publisher","unstructured":"Whiting P, Al M, Westwood M, et al. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015;19(58). https:\/\/doi.org\/10.3310\/hta19580.","DOI":"10.3310\/hta19580"},{"issue":"6","key":"R61","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.jpedsurg.2022.01.059","volume":"57","author":"Wagner","year":"2022","journal-title":"J Pediatr Surg."},{"issue":"(2)","key":"R62","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1177\/1089253217739121","volume":"22","author":"Blaine","year":"2018","journal-title":"Semin Cardiothorac Vasc Anesth."},{"issue":"(3)","key":"R63","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2450\/2018.0003-18","volume":"16","author":"Franchini","year":"2018","journal-title":"Blood Transfus."},{"issue":"(4)","key":"R64","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1055\/s-0037-1599154","volume":"43","author":"Abeysundara","year":"2017","journal-title":"Semin Thromb Hemost."},{"issue":"(1)","key":"R65","doi-asserted-by":"publisher","first-page":"R30","DOI":"10.1186\/cc13721","volume":"18","author":"M\u00fcller","year":"2014","journal-title":"Crit Care."},{"key":"R66","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jcrc.2017.09.183","volume":"44","author":"Davies","year":"2018","journal-title":"J Crit Care."},{"issue":"1","key":"R67","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1182\/asheducation-2018.1.516.","volume":"2018","author":"Bercovitz","year":"2018","journal-title":"Hematology Am Soc Hematol Educ Program."},{"issue":"1","key":"R68","doi-asserted-by":"publisher","first-page":"129","DOI":"10.21037\/acs.2018.07.03.","volume":"8","author":"Koster","year":"2019","journal-title":"Ann Cardiothorac Surg."},{"issue":"1","key":"R69","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1182\/hematology.2020000090","volume":"2020","author":"Selby","year":"2020","journal-title":"Hematology."},{"issue":"3","key":"R70","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/mat.0000000000001652","volume":"68","author":"McMichael","year":"2022","journal-title":"Asaio J."},{"issue":"6","key":"R71","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/aor.12782","volume":"41","author":"Fuchs","year":"2017","journal-title":"Artificial Organs."},{"issue":"(6)","key":"R72","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/clpt.2011.232","volume":"90","author":"Mandema","year":"2011","journal-title":"Clin Pharmacol Ther."},{"key":"R73","unstructured":"MacLaren G, Lorusso R, Brodie D, Peek GJ, Thiagaraj R, Vercaemst L. Extracorporeal Life Support: The ELSO Red Book. Extacorporeal Life Support Organization; 2022."},{"issue":"3","key":"R74","first-page":"172","volume":"15","author":"Zangrillo","year":"2013","journal-title":"Crit Care Resusc."},{"issue":"4","key":"R75","doi-asserted-by":"publisher","first-page":"A856","DOI":"10.1016\/j.chest.2019.08.815","volume":"156","author":"Hupp","year":"2019","journal-title":"Chest."},{"issue":"4","key":"R76","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1177\/02676591221082499","volume":"38","author":"Chu","year":"2023","journal-title":"Perfusion."},{"issue":"6","key":"R77","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.jpedsurg.2017.03.022","volume":"52","author":"O'Brien","year":"2017","journal-title":"J Pediatr Surg."},{"issue":"(8)","key":"R78","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.7150\/ijms.50217","volume":"18","author":"Materne","year":"2021","journal-title":"Int J Med Sci."},{"issue":"1","key":"R79","doi-asserted-by":"publisher","first-page":"e0227793","DOI":"10.1371\/journal.pone.0227793","volume":"15","author":"Appelt","year":"2020","journal-title":"Plos One."},{"issue":"3","key":"R80","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/mat.0000000000000974","volume":"66","author":"Dufour","year":"2020","journal-title":"ASAIO J."},{"issue":"(7)","key":"R81","doi-asserted-by":"publisher","first-page":"934","DOI":"10.3390\/mi15070934","volume":"15","author":"Liu","year":"2024","journal-title":"Micromachines."},{"issue":"(2)","key":"R82","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tmrv.2014.12.001","volume":"29","author":"Murphy","year":"2015","journal-title":"Transfus Med Rev."},{"issue":"6","key":"R83","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1097\/00002480-200211000-00010","volume":"48","author":"Kawahito","year":"2002","journal-title":"ASAIO J."},{"issue":"3","key":"R84","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1051\/ject\/199325387","volume":"25","author":"Bearss","year":"1993","journal-title":"J Extra Corpor Technol."},{"issue":"(11)","key":"R85","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1038\/cdd.2013.113","volume":"20","author":"Schaer","year":"2013","journal-title":"Cell Death Differ."},{"issue":"(7)","key":"R86","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/s41374-020-0403-x","volume":"100","author":"Posta","year":"2020","journal-title":"Lab Invest."},{"issue":"(12)","key":"R87","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1089\/ars.2020.8234","volume":"35","author":"Potor","year":"2021","journal-title":"Antioxid Redox Signal."},{"issue":"8","key":"R88","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1161\/ATVBAHA.123.318780","volume":"43","author":"Dimitrov","year":"2023","journal-title":"Arterioscler, Thromb, Vasc Biol."},{"issue":"2","key":"R89","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1051\/ject\/201547103","volume":"47","author":"Neal","year":"2015","journal-title":"J Extra Corpor Technol."},{"issue":"11","key":"R90","doi-asserted-by":"publisher","first-page":"e728","DOI":"10.1542\/neo.21-11-e728","volume":"21","author":"Garg","year":"2020","journal-title":"NeoRev."},{"issue":"1","key":"R91","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1051\/ject\/201345021","volume":"45","author":"Cornelius","year":"2013","journal-title":"J Extra Corpor Technol."},{"issue":"4","key":"R92","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/ijlh.14308","volume":"46","author":"Davidson","year":"2024","journal-title":"Int J Lab Hematol."},{"key":"R93","doi-asserted-by":"publisher","first-page":"893642","DOI":"10.3389\/fmed.2022.893642","volume":"9","author":"Cousin","year":"2022","journal-title":"Front Med (Lausanne)."},{"issue":"11","key":"R94","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1097\/mat.0000000000001503","volume":"67","author":"Dufour","year":"2021","journal-title":"ASAIO J."},{"key":"R95","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jcrc.2019.01.028","volume":"51","author":"Bosma","year":"2019","journal-title":"J Crit Care."},{"issue":"(1)","key":"R96","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/jcm14010140","volume":"14","author":"B\u00fcnger","year":"2025","journal-title":"J Clin Med."},{"issue":"1","key":"R97","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12967-020-02599-z","volume":"19","author":"Sch\u00f6ps","year":"2021","journal-title":"J Transl Med."},{"key":"R98","doi-asserted-by":"publisher","unstructured":"Chan CHH, Ki KK, Zhang M, et al. Extracorporeal membrane oxygenation-induced hemolysis: An in vitro study to appraise causative factors. Membranes (Basel). 2021;11(5). Epub 20210425. https:\/\/doi.org\/10.3390\/membranes11050313. PubMed PMID: 33923070; PMCID: PMC8145168.","DOI":"10.3390\/membranes11050313"},{"issue":"2","key":"R99","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/mat.0000000000001630","volume":"68","author":"Gajkowski","year":"2022","journal-title":"ASAIO J."},{"issue":"1","key":"R100","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s40635-019-0264-z","volume":"7","author":"Ki","year":"2019","journal-title":"Intensive Care Med Exp."},{"key":"R101","unstructured":"Bharadwaj M, Bora V. Venoarterial ECMO Hemodynamics. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024."},{"issue":"4","key":"R102","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1097\/mat.0000000000000538.","volume":"63","author":"Badheka","year":"2017","journal-title":"ASAIO J."},{"key":"R103","first-page":"1","volume":"14","author":"Bartlett","year":"2014","journal-title":"NIH Public Access."},{"issue":"6","key":"R104","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1097\/MAT.0b013e318186a807","volume":"54","author":"Lehle","year":"2008","journal-title":"ASAIO J."},{"issue":"(12)","key":"R105","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1007\/s10439-021-02878-w","volume":"49","author":"Sarathy","year":"2021","journal-title":"Ann Biomed Eng."},{"issue":"(12)","key":"R106","doi-asserted-by":"publisher","first-page":"e112316","DOI":"10.1371\/journal.pone.0112316","volume":"9","author":"Lubnow","year":"2014","journal-title":"PLoS One."},{"issue":"7","key":"R107","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1097\/mat.0000000000001332","volume":"67","author":"Nagler","year":"2021","journal-title":"ASAIO J."},{"issue":"1","key":"R108","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s13054-023-04503-9","volume":"27","author":"Genty","year":"2023","journal-title":"Critical Care."},{"issue":"2","key":"R109","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1051\/ject\/201951061","volume":"51","author":"Basken","year":"2019","journal-title":"J Extra Corpor Technol."},{"issue":"5","key":"R110","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1177\/02676591231168642","volume":"39","author":"van Minnen","year":"2024","journal-title":"Perfusion."},{"key":"R111","unstructured":"Extracorporeal life support organization (ELSO) General guidelines for all ECLS cases 2017. Available from: https:\/\/www.elso.org\/portals\/0\/elso%20guidelines%20general%20all%20ecls%20version%201_4.pdf."},{"issue":"1","key":"R112","doi-asserted-by":"publisher","first-page":"393258","DOI":"10.1155\/2014\/393258","volume":"2014","author":"Chung","year":"2014","journal-title":"Sci World J."},{"issue":"2","key":"R113","doi-asserted-by":"publisher","first-page":"244","DOI":"10.5005\/jp-journals-10071-24113","volume":"26","author":"Krishnamurthy","year":"2022","journal-title":"Indian J Crit Care Med."},{"issue":"5","key":"R114","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/aor.12180","volume":"38","author":"Lehle","year":"2014","journal-title":"Artif Organs."},{"key":"R115","unstructured":"AMG PMP oxygenator brochure: Abbott. Available from: https:\/\/app.looplxp.com\/external-view\/a158b7b3-e348-4e23-af3a-bcd456600be2."},{"issue":"1","key":"R116","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1186\/s13054-020-03388-2","volume":"24","author":"Zakhary","year":"2020","journal-title":"Critical Care."},{"issue":"3","key":"R117","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1182\/ject-239-241","volume":"54","author":"Wahl","year":"2022","journal-title":"J Extra Corpor Technol."},{"issue":"(1_suppl)","key":"R118","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1177\/0267659118765883","volume":"33","author":"Krivitski","year":"2018","journal-title":"Perfusion."},{"issue":"(2)","key":"R119","doi-asserted-by":"publisher","first-page":"e0263360","DOI":"10.1371\/journal.pone.0263360","volume":"17","author":"Hendrix","year":"2022","journal-title":"PLoS One."},{"issue":"2","key":"R120","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/aor.13343","volume":"43","author":"Kaesler","year":"2019","journal-title":"Artif Organs."},{"key":"R121","unstructured":"Rosario DC, Ambati S. Extracorporeal membrane oxygenation in children. 2023. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK572104\/."},{"issue":"1","key":"R122","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.suc.2021.09.001","volume":"102","author":"Wrisinger","year":"2022","journal-title":"Surg Clin North Am."},{"issue":"4","key":"R123","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.ccm.2014.08.013","volume":"35","author":"Abrams","year":"2014","journal-title":"Clin Chest Med."},{"issue":"12","key":"R124","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1164\/rccm.202004-1060ED","volume":"201","author":"Karagiannidis","year":"2020","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"R125","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5935\/0103-507x.20160006","volume":"28","author":"Park","year":"2016","journal-title":"Rev Bras Ter Intensiva."},{"key":"R126","unstructured":"Spectrum Medical \u2013 System M. Available from: https:\/\/www.spectrummedical.com\/uploads\/documents\/systemm-update_2-17_us_web.pdf."},{"key":"R127","doi-asserted-by":"crossref","unstructured":"Monitoring the patient on ECMO. In: Vuylsteke A, Brodie D, Combes A, Fowles J-a, Peek G, ed. ECMO in the Adult Patient. Cambridge: Cambridge University Press; 2017; 58\u201367.","DOI":"10.1017\/9781139088251.005"},{"issue":"12","key":"R128","doi-asserted-by":"publisher","first-page":"792","DOI":"10.21037\/atm.2020.03.186","volume":"8","author":"Su","year":"2020","journal-title":"Ann Transl Med."},{"issue":"18","key":"R129","doi-asserted-by":"publisher","first-page":"476","DOI":"10.21037\/atm.2019.08.07","volume":"7","author":"Han","year":"2019","journal-title":"Ann Transl Med."},{"issue":"4","key":"R130","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/0267659107083241","volume":"22","author":"Wagner","year":"2007","journal-title":"Perfusion."},{"issue":"Suppl 5","key":"R131","doi-asserted-by":"publisher","first-page":"S596","DOI":"10.21037\/jtd.2017.10.05","volume":"10","author":"Epis","year":"2018","journal-title":"J Thorac Dis."},{"key":"R132","unstructured":"ELSO Guidelines for patient care, respiratory & cardiac support, ECMO in COVID-19 ELSO Guidelines [cited 2025]. Available from: https:\/\/www.elso.org\/ecmo-resources\/elso-ecmo-guidelines.aspx."},{"key":"R133","unstructured":"Bishop MA, Moore A. Extracorporeal Membrane Oxygenation Weaning. StatPearls [Internet]: Treasure Island (FL): StatPearls Publishing; 2023."},{"issue":"10","key":"R134","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1007\/s11837-012-0446-6","volume":"64","author":"I-Corps and the Business of Great Science","year":"2012","journal-title":"JOM."},{"issue":"(2)","key":"R135","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s13239-021-00579-y","volume":"13","author":"Kaesler","year":"2022","journal-title":"Cardiovasc Eng Technol."},{"issue":"8","key":"R136","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1097\/mat.0000000000001089","volume":"66","author":"Birkenmaier","year":"2020","journal-title":"ASAIO J."},{"issue":"3","key":"R137","first-page":"568","volume":"34","author":"Kundu","year":"1988","journal-title":"ASAIO Trans."},{"key":"R138","doi-asserted-by":"publisher","unstructured":"Nanayakkara S, Fuchs G, Brynolf M, Prahl Wittberg L, Broman LM. Detection of thrombi in extracorporeal membrane oxygenation circuits using low-frequency acoustic measurements. ASAIO J. 2026. Epub 20260210. https:\/\/doi.org\/10.1097\/mat.0000000000002661. PubMed PMID: 41664281.","DOI":"10.1097\/mat.0000000000002661"},{"issue":"(3)","key":"R139","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/mat.0000000000002095","volume":"70","author":"Diop","year":"2024","journal-title":"ASAIO J."},{"issue":"(1_suppl)","key":"R140","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1177\/02676591231163688","volume":"38","author":"Pladet","year":"2023","journal-title":"Perfusion."},{"key":"R141","unstructured":"Hodgson C, Pellegrino V, Fulcher B. EXCEL \u2013 the Australian and New Zealand extracorporeal membrane oxygenation registry."},{"issue":"(1)","key":"R142","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41597-022-01899-x","volume":"10","author":"Johnson","year":"2023","journal-title":"Sci Data."},{"issue":"6","key":"R143","doi-asserted-by":"publisher","first-page":"e563","DOI":"10.1097\/ccm.0000000000004916","volume":"49","author":"Thoral","year":"2021","journal-title":"Crit Care Med."},{"key":"R144","unstructured":"ECLS CDM 2025. Available from: https:\/\/ecls-cdm.github.io\/cdm\/."},{"key":"R145","unstructured":"Rieder C, Zhuk O, Said A, Peta MAA, Hoechter DJ. Expanding the OMOP common data model to support extracorporeal life support research2024. Available from: https:\/\/www.ohdsi.org\/2024showcase-21\/."}],"container-title":["The Journal of ExtraCorporeal Technology"],"original-title":[],"link":[{"URL":"https:\/\/ject.edpsciences.org\/10.1051\/ject\/2026022\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:46:54Z","timestamp":1789472814000},"score":1,"resource":{"primary":{"URL":"https:\/\/ject.edpsciences.org\/10.1051\/ject\/2026022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":145,"journal-issue":{"issue":"3"},"alternative-id":["ject250100"],"URL":"https:\/\/doi.org\/10.1051\/ject\/2026022","relation":{},"ISSN":["0022-1058","2969-8960"],"issn-type":[{"value":"0022-1058","type":"print"},{"value":"2969-8960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}