{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T19:11:51Z","timestamp":1648581111767},"reference-count":8,"publisher":"EDP Sciences","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1051\/medsci\/2005212187","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T15:27:49Z","timestamp":1299338869000},"page":"187-189","source":"Crossref","is-referenced-by-count":3,"title":["Les DSMB 2. De l\u2019importance d\u2019un DSMB efficace : exemples d\u2019essais cliniques \u00ab\u00a0\u00e0 risque\u00a0\u00bb"],"prefix":"10.1051","volume":"21","author":[{"given":"Christian","family":"Brun-Buisson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2005,2,15]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Brun-Buisson C. Les DSMB. 1. Quel r\u00f4le, quelles responsabilit\u00e9s ?Med Sci (Paris)2005; 1 : 78\u201382","DOI":"10.1051\/medsci\/200521178"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Lemaire F, Brun-Buisson C. Are institutional review boards effective in safeguarding patients in intensive care units ?Curr Opin Anaesthesiol2000; 13 : 195\u2013201.","DOI":"10.1097\/00001503-200004000-00020"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Freeman BD, Danner RL, Banks SM, Natanson C. Safeguarding patients in clinical trials with high mortality rates.Am J Respir CritCare Med 2001; 164 : 190\u20132.","DOI":"10.1164\/ajrccm.164.2.2011028"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Wolkenstein P, Latarjet J, Roujeau JC, et al. Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis.Lancet1998; 352 :\u00a0 1586\u20139.","DOI":"10.1016\/S0140-6736(98)02197-7"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Naveau S, Chollet-Martin S, Dharancy S, et al. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.Hepatology2004; 39 : 1390\u20137.","DOI":"10.1002\/hep.20206"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Takala J, Ruokonen E, Webster NR, et al. Increased mortality associated with growth hormone treatment in critically ill adults.N Engl J Med1999; 341 : 785\u201392.","DOI":"10.1056\/NEJM199909093411102"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Bakker J, Grover R, McLuckie A, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis : results of a randomized, double-blind, placebo-controlled multicenter study (study n\u00b0 144-002).Crit Care Med2004; 32 : 1\u201312.","DOI":"10.1097\/01.CCM.0000105118.66983.19"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Lopez A, Lorente JA, Steingrub J, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88 : effect on survival in patients with septic shock.Crit Care Med2004; 32 : 21\u201330.","DOI":"10.1097\/01.CCM.0000105581.01815.C6"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2005212187\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T01:28:55Z","timestamp":1560043735000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2005212187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":8,"journal-issue":{"issue":"2"},"alternative-id":["medsci2005212p187"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2005212187","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}