{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:49:56Z","timestamp":1791078596465,"version":"4.1.0"},"reference-count":9,"publisher":"EDP Sciences","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1051\/medsci\/20062211906","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T12:06:28Z","timestamp":1299326788000},"page":"906-908","source":"Crossref","is-referenced-by-count":2,"title":["La cyst\u00e9amine r\u00e9tablit les dynamiques intracellulaires et la s\u00e9cr\u00e9tion du BDNF dans la maladie de Huntington"],"prefix":"10.1051","volume":"22","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Saudou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2006,11,15]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Young AB. Huntingtin in health and disease.J Clin Invest2003; 111 : 299\u2013302.","DOI":"10.1172\/JCI200317742"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Karpuj MV, Becher MW, Springer JE,et al.Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine.Nat Med2002; 8 : 143\u20139.","DOI":"10.1038\/nm0202-143"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Dedeoglu A, Kubilus JK, Jeitner TM,et al.Therapeutic effects of cystamine in a murine model of Huntington\u2019s disease.J Neurosci2002; 22 : 8942\u201350.","DOI":"10.1523\/JNEUROSCI.22-20-08942.2002"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Borrell-Pages M, Canals JM, Cordelieres FP,et al.Cystamine and cysteamine increase brain levels of BDNF in Huntington diseaseviaHSJ1b and transglutaminase.J Clin Invest2006; 116 : 1410\u201324.","DOI":"10.1172\/JCI27607"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Lesort M, Chun W, Tucholski J,et al.Does tissue transglutaminase play a role in Huntington\u2019s disease ?Neurochem Int2002; 40 : 37\u201352.","DOI":"10.1016\/S0197-0186(01)00059-6"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Gauthier LR, Charrin BC, Borrell-Pages M,et al.Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.Cell2004; 118 : 127\u201338.","DOI":"10.1016\/j.cell.2004.06.018"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Zuccato C, Ciammola A, Rigamonti D,et al.Loss of huntingtin-mediated BDNF gene transcription in Huntington\u2019s disease.Science2001; 293 : 493\u20138.","DOI":"10.1126\/science.1059581"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Cattaneo E, Zuccato C, Tartari M. Normal huntingtin function : an alternative approach to Huntington\u2019s disease.Nat Rev Neurosci2005; 6 : 919\u201330.","DOI":"10.1038\/nrn1806"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Pal A, Severin F, Lommer B,et al.Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington\u2019s disease.J Cell Biol2006; 172 : 605\u201318.","DOI":"10.1083\/jcb.200509091"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/20062211906\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T01:07:58Z","timestamp":1560042478000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/20062211906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":9,"journal-issue":{"issue":"11"},"alternative-id":["medsci20062211p906"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/20062211906","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}