{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:29:44Z","timestamp":1790746184325,"version":"4.1.0"},"reference-count":30,"publisher":"EDP Sciences","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1051\/medsci\/200622121081","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T06:42:06Z","timestamp":1299307326000},"page":"1081-1086","source":"Crossref","is-referenced-by-count":6,"title":["L\u2019adaptateur 3BP2"],"prefix":"10.1051","volume":"22","author":[{"given":"Marcel","family":"Deckert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2006,12,15]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Pawson T, Scott JD. Signaling through scaffold, anchoring, and adaptor proteins.Science1997; 278 : 2075\u201380.","DOI":"10.1126\/science.278.5346.2075"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Jordan MS, Singer AL, Koretzky GA. Adaptors as central mediators of signal transduction in immune cells.Nat Immunol2003; 4 : 110\u20136.","DOI":"10.1038\/ni0203-110"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Ren R, Mayer BJ, Cicchetti P, Baltimore D. Identification of a ten-amino acid proline-rich SH3 binding site.Science1993; 259 : 1157\u201361.","DOI":"10.1126\/science.8438166"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Deckert M, Tartare-Deckert S, Hernandez J,et al.Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.Immunity1998; 9 : 595\u2013605.","DOI":"10.1016\/S1074-7613(00)80657-3"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Bell SM, Shaw M, Jou YS,et al.Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer.Genomics1997; 44 : 163\u201370.","DOI":"10.1006\/geno.1997.4849"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Foucault I, Le Bras S, Charvet C,et al.The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor.Blood2005; 105 : 1106\u201313.","DOI":"10.1182\/blood-2003-08-2965"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Maeno K, Sada K, Kyo S,et al.Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.J Biol Chem2003; 278 : 24912\u201320.","DOI":"10.1074\/jbc.M301201200"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Songyang Z, Shoelson SE, McGlade J,et al.Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps\/fes, GRB-2, HCP, SHC, Syk, and Vav.Mol Cell Biol1994; 14 : 2777\u201385.","DOI":"10.1128\/MCB.14.4.2777"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Kendrick TS, Lipscombe RJ, Rausch O,et al.Contribution of the membrane-distal tyrosine in intracellular signaling by the granulocyte colony-stimulating factor receptor.J Biol Chem2004; 279 : 326\u201340.","DOI":"10.1074\/jbc.M310144200"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Sada K, Miah SM, Maeno K,et al.Regulation of Fc\u03b5RI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells.Blood2002; 100 : 2138\u201344.","DOI":"10.1182\/blood-2001-12-0340"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Jevremovic D, Billadeau DD, Schoon RA,et al.Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2.J Immunol2001; 166 : 7219\u201328.","DOI":"10.4049\/jimmunol.166.12.7219"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Qu X, Kawauchi-Kamata K, Miah SM,et al.Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.Biochemistry2005; 44 : 3891\u20138.","DOI":"10.1021\/bi048353o"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Foucault I, Liu YC, Bernard A, Deckert M. The chaperone protein 14-3-3 interacts with 3BP2\/SH3BP2 and regulates its adapter function.J Biol Chem2003; 278 : 7146\u201353.","DOI":"10.1074\/jbc.M209509200"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Miah SM, Hatani T, Qu X,et al.Point mutations of 3BP2 identified in human-inherited disease cherubism result in the loss of function.Genes Cells2004; 9 : 993\u20131004.","DOI":"10.1111\/j.1365-2443.2004.00784.x"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Turner M, Billadeau DD. VAV proteins as signal integrators for multi-subunit immune-recognition receptors.Nat Rev Immunol2002; 2 : 476\u201386.","DOI":"10.1038\/nri840"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Wu J, Motto DG, Koretzky GA, Weiss A. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.Immunity1996; 4 : 593\u2013602.","DOI":"10.1016\/S1074-7613(00)80485-9"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Zakaria S, Gomez TS, Savoy DN,et al.Differential regulation of TCR-mediated gene transcription by Vav family members.J Exp Med2004; 199 : 429\u201334.","DOI":"10.1084\/jem.20031228"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Saborit-Villarroya I, Del Valle JM, Romero X,et al.The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing.J Immunol2005; 175 : 4226\u201335.","DOI":"10.4049\/jimmunol.175.7.4226"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Zollino M, Di Stefano C, Zampino G,et al.Genotype-phenotype correlations and clinical diagnostic criteria in Wolf-Hirschhorn syndrome.Am J Med Genet2000; 94 : 254\u201361.","DOI":"10.1002\/1096-8628(20000918)94:3<254::AID-AJMG13>3.0.CO;2-7"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Ueki Y, Tiziani V, Santanna C,et al.Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism.Nat Genet2001; 28 : 125\u20136.","DOI":"10.1038\/88832"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Jones WA. Cherubism: A thumbnail sketch of its diagnosis and a conservative method of treatment.Oral Surg Oral Med Oral Pathol1965; 20 : 648\u201353.","DOI":"10.1016\/0030-4220(65)90111-8"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Southgate J, Sarma U, Townend JV,et al.Study of the cell biology and biochemistry of cherubism.J Clin Pathol1998; 51 : 831\u20137.","DOI":"10.1136\/jcp.51.11.831"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Imai Y, Kanno K, Moriya T,et al.A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism.Cleft Palate Craniofac J2003; 40 : 632\u20138.","DOI":"10.1597\/1545-1569_2003_040_0632_ammits_2.0.co_2"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Lo B, Faiyaz-Ul-Haque M, Kennedy S,et al.Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism.Am J Med Genet2003; 121A : 37\u201340.","DOI":"10.1002\/ajmg.a.20226"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Takayanagi H. Mechanistic insight into osteoclast differentiation in osteoimmunology.J Mol Med2005; 83 : 170\u20139.","DOI":"10.1007\/s00109-004-0612-6"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Li B, Boast S, de los Santos K,et al.Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation.Nat Genet2000; 24 : 304\u20138.","DOI":"10.1038\/73542"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Soriano P, Montgomery C, Geske R, Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.Cell1991; 64 : 693\u2013702.","DOI":"10.1016\/0092-8674(91)90499-O"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Mocsai A, Humphrey MB, Van Ziffle JA,et al.The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcR\u03b3) regulate development of functional osteoclasts through the Syk tyrosine kinase.Proc Natl Acad Sci USA2004; 101 : 6158\u201363.","DOI":"10.1073\/pnas.0401602101"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Faccio R, Teitelbaum SL, Fujikawa K,et al.Vav3 regulates osteoclast function and bone mass.Nat Med2005; 11 : 284\u201390.","DOI":"10.1038\/nm1194"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution.Annu Rev Immunol2002; 20 : 795\u2013823.","DOI":"10.1146\/annurev.immunol.20.100301.064753"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/200622121081\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T21:06:50Z","timestamp":1560028010000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/200622121081"}},"subtitle":["Quelle place pour cette prot\u00e9ine dans la signalisation des leucocytes\u00a0?"],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":30,"journal-issue":{"issue":"12"},"alternative-id":["medsci20062212p1081"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/200622121081","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}