{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:32:58Z","timestamp":1790937178744,"version":"4.1.0"},"reference-count":29,"publisher":"EDP Sciences","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1051\/medsci\/2006222206","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T07:22:29Z","timestamp":1299309749000},"page":"206-211","source":"Crossref","is-referenced-by-count":3,"title":["Progr\u00e8s scientifiques et nouvelles armes biologiques"],"prefix":"10.1051","volume":"22","author":[{"given":"Patrick","family":"Berche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2006,2,15]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Debord T, Binder P, Salomon J, Rou\u00e9 R. Les armes biologiques.Med Mal Si Infect1997; 27 : 548\u201351.","DOI":"10.1016\/S0399-077X(97)80116-3"},{"key":"R2","unstructured":"Williams P, Wallace D.La guerre bact\u00e9riologique. Le secret des exp\u00e9rimentations japonaises, Paris : Albin Michel, 1990."},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Christopher G, Cieslak T, Pavlin JA, Eitzen M. Biological warfare : a historical perspective. JAMA 1997; 278 : 412-7. 4. Wachtel C. Armes biologiques : le probl\u00e8me russe.La Recherche1998; 310 : 37\u201341","DOI":"10.1001\/jama.1997.03550050074036"},{"key":"R4","unstructured":"Alibek K, Handelman S.Biohazard. New York : Random House, 1999."},{"key":"R5","unstructured":"Miller J, Engelberg S, Broad W.Germs, biological weapons and America\u2019s secret war. New York : Simon and Schuster, 2001."},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Jackson RJ, Ramsay AJ, Christensen CD,et al.Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.J Virol2001; 75 : 1205\u201310.","DOI":"10.1128\/JVI.75.3.1205-1210.2001"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Finkel E. Australia. Engineered mouse virus spurs bioweapon fears.Science2001; 291 : 585.","DOI":"10.1126\/science.291.5504.585"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Mullbacher A, Lobigs M. Creation of killer poxvirus could have been predicted.J Virol2001; 75 : 8353\u20135.","DOI":"10.1128\/JVI.75.18.8353-8355.2001"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Kobinger GP, Weiner DJ, Yu QC, Wilson JM. Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epitheliain vivo.Nat Biotechnol2001; 19 : 225\u201330.","DOI":"10.1038\/85664"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Cello J, Paul AV, Wimmer E. Chemical synthesis of poliovirus cDNA : generation of infectious virus in the absence of natural template.Science2002; 297 : 1016\u20138.","DOI":"10.1126\/science.1072266"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Smith HO, Hutchison CA, Pfannkoch C, Venter JC. Generating a synthetic genome by whole genome assembly : phiX174 bacteriophage from synthetic oligonucleotides.Proc Natl Acad Sci USA2003; 100 : 15440\u20135.","DOI":"10.1073\/pnas.2237126100"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Berche P. The threat of smallpox and bioterrorism.Trends Microbiol2001; 9 : 15\u20138.","DOI":"10.1016\/S0966-842X(00)01855-2"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Massung RF, Liu L, Qi J, Knight JC,et al.Analysis of the complete genome of smallpox variola major virus strain Bangladesh-1975.Virology1994; 201 : 215\u201340.","DOI":"10.1006\/viro.1994.1288"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Massung RF, Esposito JJ, Liu L,et al.Potential virulence determinants in terminal regions of variola smallpox virus genome.Nature1993; 366 : 748\u201351.","DOI":"10.1038\/366748a0"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Taubenberger JK, Reid AH, Lourens RM,et al.Characterization of the 1918 influenza virus polymerase genes.Nature2005; 437 : 889\u201393.","DOI":"10.1038\/nature04230"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Ghedin E, Sengamalay NA, Shumway M,et al.Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution.Nature2005; 437 : 1162\u20136.","DOI":"10.1038\/nature04239"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Pennisi E. Molecular biology. Venter cooks up a synthetic genome in record time.Science2003; 302 : 1307.","DOI":"10.1126\/science.302.5649.1307a"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Stemmer WP. DNA shuffling by random fragmentation and reassembly :in vitrorecombination for molecular evolution.Proc Natl Acad Sci USA1994; 91 : 10747\u201351.","DOI":"10.1073\/pnas.91.22.10747"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Stemmer WP. Rapid evolution of a proteinin vitroby DNA shuffling.Nature1994; 370 : 324\u20135.","DOI":"10.1038\/370389a0"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Stemmer WP, Crameri A, Ha KD,et al.Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides.Gene1995; 164 : 49\u201353.","DOI":"10.1016\/0378-1119(95)00511-4"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Soong NW, Nomura L, Pekrun K,et al.Molecular breeding of viruses.Nat Genet2000; 25 : 436\u20139.","DOI":"10.1038\/78132"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Pekrun K, Shibata R, Igarashi T,et al.Evolution of a human immunodeficiency virus type 1 variant with enhanced replication in pig-tailed macaque cells by DNA shuffling.J Virol2002; 76 : 2924\u201335.","DOI":"10.1128\/JVI.76.6.2924-2935.2002"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Powell SK, Kaloss MA, Pinkstaff A,et al.Breeding of retroviruses by DNA shuffling for improved stability and processing yields.Nat Biotechnol2000; 18 : 1279\u201382.","DOI":"10.1038\/82391"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Matzke M, Matzke AJM, Kooter JM. RNA : guiding gene silencing.Science2001; 293 : 1080\u20133.","DOI":"10.1126\/science.1063051"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Heller T, Saito S, Auerbach J,et al.Anin vitromodel of hepatitis C production.Proc Natl Acad Sci USA2005; 102 : 2579\u201383.","DOI":"10.1073\/pnas.0409666102"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Van der Hoek L, Pyrc K, Jebbink MF,et al.Identification of a new human coronavirus.Nat Med2004; 10 : 368\u201373.","DOI":"10.1038\/nm1024"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Enserink M. Infectious diseases. One year after outbreak, SARS virus yields some secrets.Science2004; 304 : 1097.","DOI":"10.1126\/science.304.5674.1097"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"McCarthy M. Anthrax attack in the USA.Lancet Infect Dis2001; 1 : 288\u20139.","DOI":"10.1016\/S1473-3099(01)00129-3"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Dougall AL, Hayward MC, Baum A. Media exposure to bioterrorism : stress and the anthrax attacks.Psychiatry2005; 68 : 28\u201342.","DOI":"10.1521\/psyc.68.1.28.64188"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2006222206\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T21:11:06Z","timestamp":1560028266000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2006222206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":29,"journal-issue":{"issue":"2"},"alternative-id":["medsci2006222p206"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2006222206","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}