{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:41:34Z","timestamp":1791168094470,"version":"4.1.0"},"reference-count":31,"publisher":"EDP Sciences","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1051\/medsci\/2006225531","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T12:25:14Z","timestamp":1299327914000},"page":"531-536","source":"Crossref","is-referenced-by-count":17,"title":["Les lipodystrophies secondaires aux traitements antir\u00e9troviraux de l\u2019infection par le VIH"],"prefix":"10.1051","volume":"22","author":[{"given":"Jacqueline","family":"Capeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Vigouroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cervera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Maachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lagathu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Dworkin MS, Williamson JM. Adult\/adolescent spectrum of HIV disease project. AIDS wasting syndrome : trends, influence on opportunistic infections, and survival.J Acquir Immune Defic Syndr2003; 33 : 267\u201373.","DOI":"10.1097\/00126334-200306010-00024"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Jain RG, Furfine ES, Pedneault L,et al.Metabolic complications associated with antiretroviral therapy.Antiviral Res2001; 51 : 151\u201377.","DOI":"10.1016\/S0166-3542(01)00148-6"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults.N Engl J Med2005; 352 : 48\u201362.","DOI":"10.1056\/NEJMra041811"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Mattison RE, Jensen M. The adipocyte as an endocrine cell.Curr Opin Endocrinol Diabetes2003; 10 : 317\u201321.","DOI":"10.1097\/00060793-200310000-00002"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Gougeon ML, Penicaud L, Fromenty B,et al.Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations.Antivir Ther2004; 9 : 161\u201377.","DOI":"10.1177\/135965350400900206"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Nolan D, Mallal S. Complications associated with NRTI therapy : update on clinical features and possible pathogenic mechanisms.Antivir Ther2004; 9 : 849\u201363.","DOI":"10.1177\/135965350400900609"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Caron M, Auclair M, Lagathu C,et al.HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functionsin vitro.AIDS2004; 18 : 2127\u201336.","DOI":"10.1097\/00002030-200411050-00004"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Lagathu C, Bastard JP, Auclair M,et al.Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectinin vitro.Antivir Ther2004; 9 : 911\u201320.","DOI":"10.1177\/135965350400900607"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Lagathu C, Kim M, Maachi M,et al.HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissuein vitroandin vivo.Biochimie2005; 87 : 65\u201371.","DOI":"10.1016\/j.biochi.2004.12.007"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Mallon PW, Unemori P, Sedwell R,et al.In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA.J Infect Dis2005; 191 : 1686\u201396.","DOI":"10.1086\/429697"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Dowell P, Flexner C, Kwiterovich PO, Lane MD. Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors.J Biol Chem2000; 275 : 41325\u201332.","DOI":"10.1074\/jbc.M006474200"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Caron M, Auclair M, Vigouroux C,et al.The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance.Diabetes2001; 50 : 1378\u201388.","DOI":"10.2337\/diabetes.50.6.1378"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Caron M, Auclair M, Sterlingot H,et al.Some HIV protease inhibitors alter lamin A\/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation.AIDS2003; 17 : 2437\u201344.","DOI":"10.1097\/00002030-200311210-00005"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Vigouroux C. Laminopathies : lipodystrophies, insulin resistance, syndromes of accelerated ageing\u2026 and others.Ann Endocrinol (Paris)2005; 66 : 270\u20138.","DOI":"10.1016\/S0003-4266(05)81761-5"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Liu B, Wang J, Chan KM,et al.Genomic instability in laminopathy-based premature aging.Nat Med2005; 11 : 780\u20135.","DOI":"10.1038\/nm1266"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Varela I, Cadinanos J, Pendas AM,et al.Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.Nature2005; 437 : 564\u20138.","DOI":"10.1038\/nature04019"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Hadri KE, Glorian M, Monsempes C,et al.In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes.J Biol Chem2004; 279 : 15130\u201341.","DOI":"10.1074\/jbc.M312875200"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"McComsey GA, Ward DJ, Hessenthaler SM,et al.Trial to assess the regression of hyperlactatemia and to evaluate the regression of established lipodystrophy in HIV-1-positive subjects (TARHEEL ; ESS40010) study team. Improvement in lipoatrophy associated with highly active antiretroviral therapy in human immunodeficiency virus-infected patients switched from stavudine to abacavir or zidovudine : the results of the TARHEEL study.Clin Infect Dis2004; 38 : 263\u201370.","DOI":"10.1086\/380790"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Martin A, Smith DE, Carr A,et al.Mitochondrial Toxicity Study Group. Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir : the MITOX Extension Study.AIDS2004; 18 : 1029\u201336.","DOI":"10.1097\/00002030-200404300-00011"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Domingo P, Matias-Guiu X, Pujol RM,et al.Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy.AIDS1999; 13 : 2261\u20137.","DOI":"10.1097\/00002030-199911120-00008"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Nolan D, Hammond E, Martin A,et al.Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy.AIDS2003; 17 : 1329\u201338.","DOI":"10.1097\/00002030-200306130-00007"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Jan V, Cervera P, Maachi M,et al.Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients.Antivir Ther2004; 9 : 555\u201364.","DOI":"10.1177\/135965350400900412"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Weisberg SP, McCann D, Desai M,et al.Obesity is associated with macrophage accumulation in adipose tissue.J Clin Invest2003; 112 : 1796\u2013808.","DOI":"10.1172\/JCI200319246"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Cancello R, Henegar C, Viguerie N,et al.Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss.Diabetes2005; 54 : 2277\u201386.","DOI":"10.2337\/diabetes.54.8.2277"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Bastard JP, Caron M, Vidal H,et al.Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance.Lancet2002; 359 : 1026\u201331.","DOI":"10.1016\/S0140-6736(02)08094-7"},{"key":"R26","unstructured":"Hammond E, Nolan D, McKinnon E,et al.Assessing the contribution of ART, HIV and host factors to changes occurring in adipose tissue of HIV-infected individuals : risk profile for lipoatrophy.Antivir Ther2005; 10(suppl 3) : L4."},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Stulnig TM, Waldhausl W. 11beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes.Diabetologia2004; 47 : 1\u201311.","DOI":"10.1007\/s00125-003-1284-4"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells : the roles of glucocorticoids and 11-hydroxysteroid dehydrogenase.J Clin Endocrinol Metab1999; 140 : 3189\u201396.","DOI":"10.1210\/endo.140.7.6868"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Bazuine M, Carlotti F, Tafrechi RS,et al.Mitogen-activated protein kinase (MAPK) phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes.Mol Endocrinol2004; 18 : 1697\u2013707.","DOI":"10.1210\/me.2003-0213"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Degawa-Yamauchi M, Moss KA, Bovenkerk JE,et al.Regulation of adiponectin expression in human adipocytes : effects of adiposity, glucocorticoids, and tumor necrosis factor alpha.Obes Res2005; 13 : 662\u20139.","DOI":"10.1038\/oby.2005.74"},{"key":"R31","doi-asserted-by":"crossref","unstructured":"Trujillo ME, Lee MJ, Sullivan S,et al.Tumor necrosis factor (alpha) and glucocorticoid synergistically increase leptin production in human adipose tissue : role for p38 MAPK.J Clin Endocrinol Metab2006; 10 janvier :online.","DOI":"10.1210\/jc.2005-1901"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2006225531\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T14:22:12Z","timestamp":1685974932000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2006225531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":31,"journal-issue":{"issue":"5"},"alternative-id":["medsci2006225p531"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2006225531","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}