{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:35:40Z","timestamp":1774528540511,"version":"3.50.1"},"reference-count":10,"publisher":"EDP Sciences","issue":"8-9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1051\/medsci\/2010268-9690","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T08:29:32Z","timestamp":1299140972000},"page":"690-693","source":"Crossref","is-referenced-by-count":2,"title":["Spermatogen\u00e8se normale chez un homme avec d\u00e9faut g\u00e9n\u00e9tique de la LH"],"prefix":"10.1051","volume":"26","author":[{"given":"G\u00e9ri","family":"M\u00e9duri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine","family":"Courtillot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Lahuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Kuttenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Touraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micheline","family":"Misrahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2010,8,15]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"McLachlan RI, O\u2019Donnell L, Meachem SJ,et al. Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man.Recent Prog Horm Res2002 ; 57 : 149-79.","DOI":"10.1210\/rp.57.1.149"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Kamischke A, Nieschlag E. Progress towards hormonal male contraception.Trends Pharmacol Sci2004 ; 25 : 49-57.","DOI":"10.1016\/j.tips.2003.11.009"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Meduri G, Bachelot A, Cocca MP,et al. Molecular pathology of the FSH receptor: new insights into FSH physiology.Mol Cell Endocrinol2008 ; 282 : 130-42.","DOI":"10.1016\/j.mce.2007.11.027"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Weiss J, Axelrod L, Whitcomb RW,et al. Hypogonadism caused by a single amino acid substitution in the \u03b2-subunit of luteinizing hormone.N Engl J Med1992 ; 326 : 179-83.","DOI":"10.1056\/NEJM199201163260306"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Axelrod L, Neer RM, Kliman B. Hypogonadism in a male with immunologically active, biologically inactive luteinizing hormone: an exception to a venerable rule. JClin Endocrinol Metab1979 ; 48 : 279-87.","DOI":"10.1210\/jcem-48-2-279"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Valdes-Socin H, Salvi R, Daly AF,et al. Hypogonadism in a patient with a mutation in the luteinizing \u03b2-subunit gene.N Engl J Med2004 ; 351 : 2619-25.","DOI":"10.1056\/NEJMoa040326"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Lofrano-Porto A, Barra GB, Giacomini LA,et al. Luteinizing hormone \u03b2 mutation and hypogonadism in men and woman.N Engl J Med2007 ; 357 : 897-904.","DOI":"10.1056\/NEJMoa071999"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Wu X, Wan S, Lee MM. Key factors in the regulation of fetal and postnatal Leydig cell development.J Cell Physiol2007 ; 213 : 429-33.","DOI":"10.1002\/jcp.21231"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Achard C, Courtillot C, Lahuna O,et al. Quantitatively normal spermatogenesis in familial hypogonadism with mutation of the Beta subunit of luteinizing hormone.N Engl J Med2009 ; 361 : 1856-63.","DOI":"10.1056\/NEJMoa0805792"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Bougneres P, Francois M, Pantalone L,et al. Effects of an early postnatal treatment of hypogonadotropic hypogonadism with a continuous subcutaneous infusion of recombinant follicle-stimulating hormone and luteinizing hormone.J Clin Endocrinol Metab2008 ; 93 : 2202-5.","DOI":"10.1210\/jc.2008-0121"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2010268-9690\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T23:41:03Z","timestamp":1560037263000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.medecinesciences.org\/10.1051\/medsci\/2010268-9690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":10,"journal-issue":{"issue":"8-9"},"alternative-id":["medsci2010268-9p690"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2010268-9690","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}