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Ces avanc\u00e9es ont permis de comprendre les m\u00e9canismes mol\u00e9culaires contr\u00f4lant l\u2019expression des g\u00e8nes en r\u00e9ponse \u00e0 des changements environnementaux et dans l\u2019adaptation physiopathologique des organes. En particulier, les longs ARN non codants apparaissent comme d\u2019importants r\u00e9gulateurs \u00e9pig\u00e9n\u00e9tiques r\u00e9gulant le remodelage de la chromatine. Dans le c\u0153ur, ces transcrits contr\u00f4lent la sp\u00e9cification et la diff\u00e9renciation cellulaires au cours du d\u00e9veloppement. Par ailleurs, ils participent, chez l\u2019adulte, \u00e0 l\u2019adaptation au stress h\u00e9modynamique faisant suite \u00e0 un dommage tissulaire. 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