{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:25:38Z","timestamp":1790691938765,"version":"4.1.0"},"reference-count":48,"publisher":"EDP Sciences","issue":"10","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Le virus de l\u2019h\u00e9patite delta, aussi appel\u00e9 virus de l\u2019h\u00e9patite D ou HDV, est un agent viral d\u00e9fectif \u00e0 ARN de polarit\u00e9 n\u00e9gative. Il se r\u00e9plique dans les cellules de mammif\u00e8re et infecte l\u2019homme. Son g\u00e9nome est un petit ARN circulaire monocat\u00e9naire d\u2019environ 1\u2009680 nucl\u00e9otides. Pour se propager, HDV a cependant besoin d\u2019un autre virus, le virus de l\u2019h\u00e9patite B (HBV), qui lui fournit les prot\u00e9ines d\u2019enveloppe n\u00e9cessaires \u00e0 l\u2019assemblage de ses virions et \u00e0 la propagation de l\u2019infection. Les manifestations cliniques graves de l\u2019infection combin\u00e9e HBV-HDV vont des formes aigu\u00ebs d\u2019h\u00e9patites fulminantes aux formes chroniques de fibroses du foie (cirrhose), qui peuvent conduire \u00e0 un carcinome h\u00e9patocellulaire. Une originalit\u00e9 de l\u2019HDV repose sur la ressemblance de son g\u00e9nome avec celui des viro\u00efdes, des agents infectieux des plantes constitu\u00e9s de petits ARN circulaires non encapsid\u00e9s. D\u00e9pourvu de toute activit\u00e9 r\u00e9plicase virale, l\u2019HDV doit utiliser l\u2019activit\u00e9 ARN polym\u00e9rase-ADN d\u00e9pendante de la cellule qu\u2019il infecte pour r\u00e9pliquer son ARN g\u00e9nomique. Comment d\u00e8s lors, cette r\u00e9plication se r\u00e9alise ? Nous aborderons dans cette revue les principales \u00e9tapes de la transcription et de la r\u00e9plication de ces ARN viraux.<\/jats:p>","DOI":"10.1051\/medsci\/2018209","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T09:06:15Z","timestamp":1542618375000},"page":"833-841","source":"Crossref","is-referenced-by-count":4,"title":["R\u00e9plication du g\u00e9nome du virus de l\u2019h\u00e9patite delta\u00a0: un r\u00f4le pour la petite prot\u00e9ine delta S-HDAg"],"prefix":"10.1051","volume":"34","author":[{"given":"Natali","family":"Abeywickrama-Samarakoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Cortay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Sureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce","family":"Alfaiate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Levrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"D\u00e9ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gut.18.12.997","volume":"18","author":"Rizzetto","year":"1977","journal-title":"Gut"},{"key":"R2","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1073\/pnas.77.10.6124","volume":"77","author":"Rizzetto","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"R3","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/j.jhep.2016.02.013","volume":"64","author":"Sureau","year":"2016","journal-title":"J Hepatol"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Lempp FA, Urban S. 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