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Celui-ci assemble un inflammasome, un complexe cytosolique de signalisation qui active la caspase-1, contr\u00f4le la lib\u00e9ration de cytokines et de facteurs inflammatoires produits dans le cytosol comme les interleukines 1\u03b1\/\u03b2 Les pathologies inflammatoires associ\u00e9es \u00e0 NLRP3, dont la goutte, r\u00e9v\u00e8lent la n\u00e9cessit\u00e9 d\u2019un contr\u00f4le \u00e9troit de son activit\u00e9. Cette revue pr\u00e9sente les avanc\u00e9es sur la signalisation du priming (ou amor\u00e7age) du complexe puis de son activation avec une attention particuli\u00e8re sur le r\u00f4le des modifications post-traductionnelles de NLRP3.<\/jats:p>","DOI":"10.1051\/medsci\/20183401013","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T08:51:25Z","timestamp":1517388685000},"page":"47-53","source":"Crossref","is-referenced-by-count":28,"title":["NLRP3, un inflammasome sous contr\u00f4le"],"prefix":"10.1051","volume":"34","author":[{"given":"Marine","family":"Groslambert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte F.","family":"Py","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1051\/medsci\/20132911013","volume":"29","author":"Jamilloux","year":"2013","journal-title":"Med Sci (Paris)"},{"key":"R2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"R3","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1051\/medsci\/20132912015","volume":"29","author":"Cabon","year":"2013","journal-title":"Med Sci (Paris)"},{"key":"R4","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"key":"R5","first-page":"1","volume":"33","author":"Shinkai","year":"2008","journal-title":"Clin Exp Dermatol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"R7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat Med"},{"key":"R8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cmet.2013.09.010","volume":"18","author":"Youm","year":"2013","journal-title":"Cell Metab"},{"key":"R9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nri3705","volume":"14","author":"Heneka","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"R10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat Immunol"},{"key":"R11","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1051\/medsci\/20082411916","volume":"24","author":"Dostert","year":"2008","journal-title":"Med Sci (Paris)"},{"key":"R12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/imr.12286","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol Rev."},{"key":"R13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2016.01.012","volume":"44","author":"Gaidt","year":"2016","journal-title":"Immunity"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Jamilloux Y, Lefeuvre L, Magnotti F, et al. 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