{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:19:40Z","timestamp":1790489980304,"version":"4.1.0"},"reference-count":9,"publisher":"EDP Sciences","issue":"1","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Selon l\u2019Organisation de coop\u00e9ration et de d\u00e9veloppement \u00e9conomiques (OCDE), les d\u00e9penses de m\u00e9dicaments repr\u00e9sentent environ 20 % de l\u2019ensemble des d\u00e9penses de sant\u00e9 des pays \u00e0 haut revenu. L\u2019augmentation de ces d\u00e9penses que l\u2019on observe dans tous ces pays sur une longue p\u00e9riode, tient \u00e0 la conjonction du vieillissement des populations, des changements de pratiques m\u00e9dicales et de la dynamique du march\u00e9 pharmaceutique, en particulier, du march\u00e9 hospitalier. La France ne fait pas exception. Sa consommation de m\u00e9dicaments (qui repr\u00e9sentait 17,5 % des d\u00e9penses de sant\u00e9 en 2014), historiquement sup\u00e9rieure en volume, a pourtant cr\u00fb moins vite au cours de la derni\u00e8re d\u00e9cennie que dans les autres pays de l\u2019OCDE. Toutefois, l\u2019adoption particuli\u00e8rement rapide et large des innovations pharmaceutiques, qui a toujours caract\u00e9ris\u00e9 la France, a eu, ces derni\u00e8res ann\u00e9es, un effet tr\u00e8s significatif sur l\u2019envol\u00e9e des d\u00e9penses couvertes par le syst\u00e8me de protection sociale (plus 1,1 milliards en 2014, une ann\u00e9e marqu\u00e9e par l\u2019arriv\u00e9e des nouvelles th\u00e9rapeutiques contre l\u2019h\u00e9patite C). Cet effet significatif devrait perdurer, avec la mise sur le march\u00e9 de nouvelles th\u00e9rapeutiques tr\u00e8s co\u00fbteuses, en particulier en oncologie.<\/jats:p>","DOI":"10.1051\/medsci\/20183401018","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T08:51:25Z","timestamp":1517388685000},"page":"83-86","source":"Crossref","is-referenced-by-count":4,"title":["\u00c9volution, d\u00e9terminants et r\u00e9gulation des d\u00e9penses de m\u00e9dicaments en France"],"prefix":"10.1051","volume":"34","author":[{"given":"Catherine","family":"Le Gal\u00e8s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"R1","unstructured":"Belloni A, Morgan D, Paris V. Pharmaceutical expenditure and policies. Paris : OECD Publishing, 2016."},{"key":"R2","unstructured":"Bureau des comptes et pr\u00e9visions d\u2019ensemble et mission des relations et \u00e9tudes internationales. Les d\u00e9penses de sant\u00e9 en 2014. In : Drees, ed. Paris : Minist\u00e8re de la Sant\u00e9, 2015."},{"key":"R3","unstructured":"Beffy M, Roussel R, Solard J, et al. Les d\u00e9penses de sant\u00e9 en 2015, \u00e9dition 2016. In : Drees, ed. Collection Panorama. Paris : Commission des Comptes de la Sant\u00e9, 2016."},{"key":"R4","unstructured":"Ferrier-Battner A, Chahwakilian P, De Pouvourville G, et al. \u00c9volution compar\u00e9e des ventes de m\u00e9dicaments dans 7 pays europ\u00e9ens (2000-20H). Paris : LIR, 2012 : 34 p."},{"key":"R5","unstructured":"Polton D. Rapport sur la r\u00e9forme des modalit\u00e9s d\u2019\u00e9valuation des m\u00e9dicaments. Paris : Minist\u00e8re de la Sant\u00e9 et des Affaires Sociales, 2015."},{"key":"R6","unstructured":"Pichetti S, Sermet C, Van Der Erf S. La diffusion des nouveaux antidiab\u00e9tiques : une comparaison internationale. IRDES, Questions d\u2019\u00c9conomie de la Sant\u00e9 2013; 1-8."},{"key":"R7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s40258-013-0014-4","volume":"11","author":"Pichetti","year":"2013","journal-title":"Appl Health Econ Health Policy"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1051\/medsci\/20173312017","volume":"33","author":"Franc","year":"2017","journal-title":"Med Sci (Paris)"},{"key":"R9","unstructured":"Greene JA. Prescribing by numbers: drugs and the definition of disease. Baltimore : Johns Hopkins University Press : 2006."}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/20183401018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T19:51:58Z","timestamp":1584647518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/20183401018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":9,"journal-issue":{"issue":"1"},"alternative-id":["medsci20183401p83"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/20183401018","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}