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En p\u00e9riph\u00e9rie, cette baisse du taux circulant d\u2019ApN induit l\u2019\u00e9tablissement d\u2019un \u00e9tat inflammatoire chronique \u00e0 bas bruit, le d\u00e9veloppement d\u2019une r\u00e9sistance \u00e0 l\u2019insuline et de plaques d\u2019ath\u00e9rome. Inversement, des conditions de vie \u00ab\u00a0favorables\u00a0\u00bb, la perte de poids et la pratique r\u00e9guli\u00e8re d\u2019exercice physique permettent d\u2019augmenter la concentration sanguine d\u2019ApN. Certaines formes d\u2019ApN peuvent gagner le cerveau par le biais du liquide c\u00e9r\u00e9brospinal. \u00c0 ce niveau, l\u2019augmentation de l\u2019ApN exerce de puissants effets anti-d\u00e9presseurs et anxiolytiques, notamment en r\u00e9duisant la 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