{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:40:45Z","timestamp":1753274445244},"reference-count":46,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Le diab\u00e8te de type 2 (DT2) est un facteur de risque ind\u00e9pendant de l\u2019insuffisance cardiaque. Ces anomalies sont cependant associ\u00e9es \u00e0 une lipotoxicit\u00e9 et \u00e0 une glucotoxicit\u00e9 cardiaques. Pourtant, les m\u00e9canismes exacts de ces toxicit\u00e9s cardiaques demeurent inconnus. R\u00e9cemment, le ph\u00e9notype cardiaque d\u2019un mod\u00e8le unique de DT2, les souris lipodystrophiques invalid\u00e9es pour le g\u00e8ne codant la seipine (SKO), a r\u00e9v\u00e9l\u00e9 l\u2019importance de la glucotoxicit\u00e9 dans le d\u00e9veloppement des anomalies cardiaques. En effet, les souris SKO pr\u00e9sentent une cardiomyopathie associ\u00e9e \u00e0 une surcharge en glucose, qui est corrig\u00e9e par l\u2019utilisation d\u2019un agent hypoglyc\u00e9miant, un inhibiteur du co-transporteur sodium-glucose de type 2 (SGLT2). Dans ce mod\u00e8le, la glucotoxicit\u00e9 peut ainsi, \u00e0 elle seule, g\u00e9n\u00e9rer les dysfonctions cardiaques associ\u00e9es au diab\u00e8te.<\/jats:p>","DOI":"10.1051\/medsci\/20183406016","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T10:21:42Z","timestamp":1533118902000},"page":"563-570","source":"Crossref","is-referenced-by-count":2,"title":["Au c\u0153ur de la cardiomyopathie diab\u00e9tique"],"prefix":"10.1051","volume":"34","author":[{"given":"Alexandre","family":"Lugat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Joubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Cariou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Prieur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"R1","first-page":"619","volume":"34\u201335","author":"Fosse-Edorh","year":"2015","journal-title":"Synth\u00e8se et perspectives. 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