{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:08:54Z","timestamp":1761156534407},"reference-count":16,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>La e-sant\u00e9 est \u00e0 la mode, mais les \u00e9l\u00e9ments cliniques d\u00e9montrant son utilit\u00e9 sont rares et se limitent \u00e0 de la transmission de donn\u00e9es relatant des sympt\u00f4mes, sans analyse sp\u00e9cifique. La th\u00e9orie du chaos est applicable \u00e0 la dynamique du cancer. Elle apporte des possibilit\u00e9s d\u2019utilisation de ses propri\u00e9t\u00e9s pour d\u00e9velopper des outils pratiques de surveillance pertinents et valid\u00e9s pour les patients. La th\u00e9orie du chaos d\u00e9terministe est applicable \u00e0 la compr\u00e9hension de la dynamique tumorale du fait des interactions entre les cellules tumorales, endoth\u00e9liales et immunitaires. La th\u00e9orie de l\u2019observabilit\u00e9 est une de ses propri\u00e9t\u00e9s qui sugg\u00e8re que le suivi de l\u2019h\u00f4te (le patient, par ses sympt\u00f4mes et son poids) est une variable puissante pour \u00e9valuer la dynamique de la maladie et son impact. Le suivi intensif et l\u2019analyse des sympt\u00f4mes des patients pour d\u00e9tecter des r\u00e9cidives et des complications cliniques par une <jats:italic>web-application<\/jats:italic> (<jats:italic>Moovcare<\/jats:italic><jats:sup>TM<\/jats:sup>) ont d\u00e9montr\u00e9 leur int\u00e9r\u00eat chez pr\u00e8s de 300 patients dans 4 \u00e9tudes prospectives dont 1 essai pilote montrant un b\u00e9n\u00e9fice de 27 % en survie \u00e0 1 an, et un essai randomis\u00e9 de phase 3 avec un b\u00e9n\u00e9fice de 26 % de survie \u00e0 1 an, par rapport \u00e0 un suivi classique. Six autres \u00e9tudes de suivi intensif montrent des r\u00e9sultats favorables en oncologie pour un total de plus de 2 000 patients randomis\u00e9s.<\/jats:p>","DOI":"10.1051\/medsci\/20183406020","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T10:21:42Z","timestamp":1533118902000},"page":"590-594","source":"Crossref","is-referenced-by-count":5,"title":["Suivi et survie des patients atteints de cancer du poumon par <i>web-application<\/i>"],"prefix":"10.1051","volume":"34","author":[{"given":"Fabrice","family":"Denis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jtbi.2013.01.003","volume":"322","author":"Letellier","year":"2013","journal-title":"J Theor Biol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jtbi.2014.06.020","volume":"360","author":"Viger","year":"2014","journal-title":"J Theor Biol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.canrad.2012.01.003","volume":"16","author":"Denis","year":"2012","journal-title":"Cancer Radiother"},{"key":"R4","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nrc2013","volume":"6","author":"Merlo","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"R5","doi-asserted-by":"crossref","first-page":"e411","DOI":"10.1038\/cddis.2012.148","volume":"3","author":"Chan","year":"2012","journal-title":"Cell Death Dis"},{"key":"R6","doi-asserted-by":"crossref","first-page":"066213","DOI":"10.1103\/PhysRevE.71.066213","volume":"71","author":"Letellier","year":"2005","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"key":"R7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00520-013-1954-9","volume":"22","author":"Denis","year":"2014","journal-title":"Support Care Cancer"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s00520-013-2111-1","volume":"22","author":"Denis","year":"2014","journal-title":"Support Care Cancer"},{"key":"R9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/COC.0000000000000189","volume":"40","author":"Denis","year":"2017","journal-title":"Am J Clin Oncol"},{"key":"R10","first-page":"109","volume":"1","author":"Denis","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"R11","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1001\/jama.288.23.3027","volume":"288","author":"Detmar","year":"2002","journal-title":"JAMA"},{"key":"R12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1200\/JCO.2013.48.6662","volume":"32","author":"Berry","year":"2014","journal-title":"J Clin Oncol"},{"key":"R13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/annonc\/mdv576","volume":"27","author":"Strasser","year":"2016","journal-title":"Ann Oncol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1200\/JCO.2014.58.6362","volume":"33","author":"Bakitas","year":"2015","journal-title":"J Clin Oncol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1200\/JCO.2015.63.0830","volume":"34","author":"Basch","year":"2015","journal-title":"J Clin Oncol"},{"key":"R16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJMoa1000678","volume":"363","author":"Temel","year":"2010","journal-title":"N Engl J Med"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/20183406020\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T19:51:34Z","timestamp":1584647494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/20183406020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":16,"journal-issue":{"issue":"6-7"},"alternative-id":["msc170113"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/20183406020","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}