{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T18:48:17Z","timestamp":1720723697713},"reference-count":10,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Les myopathies inflammatoires et dysimmunitaires (DIMs) touchent 14\/100\u2009000 personnes dans le monde. Ces pathologies sont class\u00e9es par des crit\u00e8res immunopathologiques en quatre groupes : (1) polymyosites (PM)\/ myosites \u00e0 inclusions (IBM), (2) dermatomyosites, (3) myopathies n\u00e9crosantes auto-immunes et (4) myosites de chevauchement comprenant le syndrome anti-synth\u00e9tase (ASS). Les ASS et PM\/IBM sont caract\u00e9ris\u00e9es par la pr\u00e9sence d\u2019infiltrats inflammatoires mononucl\u00e9\u00e9s. R\u00e9cemment, nous avons mis en \u00e9vidence une expression myocytaire du complexe majeur d\u2019histocompatibilit\u00e9 de type 2 (CMH2) dans les muscles de patients atteints d\u2019ASS et d\u2019IBM. L\u2019expression du CMH2 est connue pour \u00eatre induite par l\u2019interf\u00e9ron-gamma (IFN\u03b3) dans les cellules myog\u00e9niques. Or, les lymphocytes T CD8 (LTCD8), cellules productrices d\u2019IFN\u03b3 sont retrouv\u00e9s \u00e0 proximit\u00e9 des fibres musculaires CMH2 positives. Cette cytokine inhibe la diff\u00e9renciation musculaire <jats:italic>in vitro<\/jats:italic> par l\u2019interaction CIITA-myog\u00e9nine (CIITA : <jats:italic>major histocompatibility complex class II transactivator<\/jats:italic>). Les m\u00e9canismes impliquant une toxicit\u00e9 musculaire m\u00e9di\u00e9e par les lymphocytes dans les DIMs restent inconnus. Les objectifs de ce projet sont dans un premier temps de caract\u00e9riser les effets de l\u2019IFN\u03b3 sur la biologie des cellules musculaires par des approches morphologiques, mol\u00e9culaires et cellulaires. Puis, d\u2019identifier le r\u00f4le de l\u2019IFN\u03b3 dans ces myopathies et son impact au cours de la r\u00e9g\u00e9n\u00e9ration musculaire. Des \u00e9tudes pr\u00e9liminaires <jats:italic>in vitro<\/jats:italic> ont \u00e9t\u00e9 r\u00e9alis\u00e9es sur des myoblastes humains et murins expos\u00e9s ou non \u00e0 l\u2019IFN\u03b3. Nos r\u00e9sultats devraient permettre d\u2019obtenir de meilleures connaissances sur la physiopathologie des DIMs et d\u2019identifier de potentielles nouvelles cibles th\u00e9rapeutiques.<\/jats:p>","DOI":"10.1051\/medsci\/201834s210","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T08:51:51Z","timestamp":1542012711000},"page":"35-38","source":"Crossref","is-referenced-by-count":0,"special_numbering":"Hors s\u00e9rie n\u00b02","title":["15<sup>es<\/sup> JSFM : Prix Master 2017"],"prefix":"10.1051","volume":"34","author":[{"given":"Cyrielle","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine","family":"Baba-Amer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilien","family":"Bencze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Relaix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"J\u00e9r\u00f4me Authier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1242\/dev.115386","volume":"142","author":"Kostallari","year":"2015","journal-title":"Development"},{"key":"R2","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1242\/dev.069088","volume":"139","author":"Relaix","year":"2012","journal-title":"Development"},{"key":"R3","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.nmd.2013.07.007","volume":"23","author":"De Bleecker","year":"2013","journal-title":"The Netherlands. Neuromuscul Disord"},{"key":"R4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/art.40328","volume":"70","author":"Gitiaux","year":"2018","journal-title":"Arthritis Rheumatol Hoboken NJ"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Rigolet M, Hou C, Baba Amer Y, et al. Distinct interferon signatures stratify inflammatory and dysimmune myopathies. 2018 (soumis pour publication).","DOI":"10.1016\/j.nmd.2017.06.231"},{"key":"R6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s40478-014-0154-2","volume":"2","author":"Aouizerate","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"R7","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1128\/MCB.05397-11","volume":"31","author":"Londhe","year":"2011","journal-title":"CIITA. 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