{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:42:06Z","timestamp":1790534526669,"version":"4.1.0"},"reference-count":32,"publisher":"EDP Sciences","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>L\u2019autisme est une pathologie neuro-d\u00e9veloppementale touchant pr\u00e8s de 1 enfant sur 100 dans le monde. Par les traumatismes et les cons\u00e9quences sociales qu\u2019il engendre, il constitue aujourd\u2019hui un v\u00e9ritable enjeu de sant\u00e9 publique. Cliniquement, l\u2019autisme se caract\u00e9rise principalement par des d\u00e9ficits de communication et d\u2019interactions sociales associ\u00e9s \u00e0 des comportements r\u00e9p\u00e9titifs et des centres d\u2019int\u00e9r\u00eats restreints. On parle de troubles du spectre autistique (TSA) pour rendre compte de la diversit\u00e9 des sympt\u00f4mes caract\u00e9risant cette pathologie. Fond\u00e9 sur des observations r\u00e9alis\u00e9es chez l\u2019homme, un mod\u00e8le de l\u2019autisme, par une exposition pr\u00e9natale de rongeurs (rats et souris) au valproate de sodium, a \u00e9t\u00e9 obtenu et valid\u00e9. \u00c0 partir de ce mod\u00e8le, des m\u00e9canismes qui concernent aussi bien le fonctionnement des r\u00e9seaux neuronaux que les propri\u00e9t\u00e9s des neurones permettant de rendre compte de certains TSA, ont \u00e9t\u00e9 propos\u00e9s. Ce mod\u00e8le est \u00e9galement largement utilis\u00e9 dans les \u00e9tudes pr\u00e9cliniques qui ont pour but de tester des th\u00e9rapies potentielles contre les TSA.<\/jats:p>","DOI":"10.1051\/medsci\/2019036","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T07:49:06Z","timestamp":1554104946000},"page":"236-243","source":"Crossref","is-referenced-by-count":20,"title":["Les mod\u00e8les animaux d\u2019\u00e9tude de l\u2019autisme"],"prefix":"10.1051","volume":"35","author":[{"given":"Jean-Louis","family":"Bossu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"R1","first-page":"217","volume":"2","author":"Kanner","year":"1943","journal-title":"Nervous Child"},{"key":"R2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3917\/psye.482.0391","volume":"48","author":"Guibert","year":"2005","journal-title":"Psychiatrie de l\u2019Enfant"},{"key":"R3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01531288","volume":"9","author":"Wing","year":"1979","journal-title":"J Autism Dev Disord"},{"key":"R4","unstructured":"DSM-III. 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