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Alors qu\u2019il est possible pour un clinicien d\u2019\u00e9tablir un diagnostic n\u00e9onatal du syndrome d\u2019alcoolisation f\u0153tale, l\u2019atteinte la plus s\u00e9v\u00e8re des troubles caus\u00e9s par l\u2019alcoolisation f\u0153tale (TCAF), une grande majorit\u00e9 des enfants \u00e9chappe \u00e0 un diagnostic pr\u00e9coce en raison de l\u2019absence d\u2019anomalies morphologiques \u00e9videntes. Plusieurs ann\u00e9es de prise en charge sont alors perdues. Des avanc\u00e9es r\u00e9centes ont permis d\u2019\u00e9tablir l\u2019existence d\u2019un axe fonctionnel placenta-cerveau impliqu\u00e9 dans le contr\u00f4le de l\u2019angiogen\u00e8se c\u00e9r\u00e9brale, qui se trouve d\u00e9r\u00e9gul\u00e9 chez les enfants expos\u00e9s <jats:italic>in utero<\/jats:italic> \u00e0 l\u2019alcool. Une angiogen\u00e8se c\u00e9r\u00e9brale normale \u00e9tant un pr\u00e9requis \u00e0 l\u2019\u00e9tablissement d\u2019un neurod\u00e9veloppement correct, ces avanc\u00e9es ouvrent la voie \u00e0 l\u2019identification d\u2019une nouvelle g\u00e9n\u00e9ration de biomarqueurs placentaires d\u2019atteinte c\u00e9r\u00e9brale pour le diagnostic pr\u00e9coce des enfants TCAF.<\/jats:p>","DOI":"10.1051\/medsci\/2019167","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T09:26:51Z","timestamp":1576574811000},"page":"859-865","source":"Crossref","is-referenced-by-count":4,"title":["Alcoolisation f\u0153tale"],"prefix":"10.1051","volume":"35","author":[{"given":"Camille","family":"Sautreuil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Laquerri\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Lecuyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Brasse-Lagnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"J\u00e9gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumeya","family":"Bekri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Marcorelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Marret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1016\/S2214-109X(17)30021-9","volume":"5","author":"Popova","year":"2017","journal-title":"Lancet Glob Health"},{"key":"R2","unstructured":"World Health Organization. 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