{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:38:25Z","timestamp":1773913105544,"version":"3.50.1"},"reference-count":30,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Les dermatomyosites (DM) sont des maladies auto-immunes rares du groupe des myopathies inflammatoires idiopathiques, d\u00e9finies par une atteinte cutan\u00e9e caract\u00e9ristique. Elles peuvent survenir dans l\u2019enfance, ou chez l\u2019adulte. Il existe des variations ph\u00e9notypiques entre les DM concernant la pr\u00e9sentation cutan\u00e9omusculaire (ex: amyopathique) mais aussi la pr\u00e9sentation extra-cutan\u00e9omusculaire (ex: atteinte pulmonaire ou articulaire associ\u00e9e). Le caract\u00e8re auto-immun de ces pathologies est soulign\u00e9 dans 60\u00a0% des cas par la pr\u00e9sence d\u2019anticorps sp\u00e9cifique de myosite. Ces derniers sont associ\u00e9s \u00e0 la pr\u00e9sence de caract\u00e9ristiques cliniques, histologiques, mais aussi pronostiques. Ils sont au nombre de cinq, les anti-Mi2, anti-Tif1-\u03b3, anti-NXP2, anti-MDA5 et anti-SAE. Les anti-Mi2 sont associ\u00e9es \u00e0 une forme clinique cutan\u00e9e classique, une atteinte musculaire souvent s\u00e9v\u00e8re au diagnostic et une bonne \u00e9volution sous traitement. Les deux suivants, fr\u00e9quents chez l\u2019enfant et l\u2019adulte, sont associ\u00e9s \u00e0 des formes r\u00e9cidivantes cutan\u00e9es et sont fortement associ\u00e9s aux cancers chez l\u2019adulte. Les anti-MDA5 sont les anticorps associ\u00e9s aux formes les plus syst\u00e9miques avec une atteinte pulmonaire interstitielle rapidement progressive pouvant \u00eatre tr\u00e8s grave. Enfin, les anti-SAE n\u2019ont \u00e9t\u00e9 d\u00e9crits que chez l\u2019adulte, avec une atteinte classique.<\/jats:p>","DOI":"10.1051\/medsci\/2019178","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T09:02:39Z","timestamp":1576832559000},"page":"18-23","source":"Crossref","is-referenced-by-count":10,"special_numbering":"Hors s\u00e9rie n\u00b0 2","title":["Dermatomyosites Nouveaux anticorps, nouvelle classification"],"prefix":"10.1051","volume":"35","author":[{"given":"Lo\u00efs","family":"Bolko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Gitiaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Allenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11926-018-0733-5","volume":"20","author":"Wolstencroft","year":"2018","journal-title":"Curr Rheumatol Rep"},{"key":"R2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaut.2017.06.007","volume":"84","author":"Tansley","year":"2017","journal-title":"J Autoimmun"},{"key":"R3","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/art.40320","volume":"69","author":"Lundberg","year":"2017","journal-title":"Arthritis Rheum (Hoboken, NJ)"},{"key":"R4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.nmd.2004.02.006","volume":"14","author":"Hoogendijk","year":"2004","journal-title":"Neuromuscul Disord"},{"key":"R5","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1001\/jamaneurol.2018.2598","volume":"75","author":"Mariampillai","year":"2018","journal-title":"JAMA Neurol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"Bohan","year":"1975","journal-title":"N Engl J Med"},{"key":"R7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0090-1229(76)90145-8","volume":"5","author":"Reichlin","year":"1976","journal-title":"Clin Immunol Immunopathol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00005792-199111000-00002","volume":"70","author":"Love","year":"1991","journal-title":"Medicine (Baltimore)"},{"key":"R9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.autrev.2018.10.004","volume":"18","author":"Damoiseaux","year":"2019","journal-title":"Autoimmun Rev"},{"key":"R10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/ard.2005.040717","volume":"65","author":"Hengstman","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Landon-Cardinal O, Monseau G, Schoindre Y, et al.\nAnti-Mi2 dermatomyositis revisited: pure DM phenotype with muscle fiber necrosis and high risk of malignancy [abstract]. 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