{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:54:57Z","timestamp":1740160497514,"version":"3.37.3"},"reference-count":15,"publisher":"EDP Sciences","issue":"12","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>La place des anticorps th\u00e9rapeutiques dans les maladies cardiovasculaires et m\u00e9taboliques est encore modeste en 2019 en comparaison \u00e0 leur incroyable d\u00e9veloppement dans d\u2019autres champs pathologiques. Cependant, l\u2019arriv\u00e9e r\u00e9cente des anticorps anti-PCSK9 (<jats:italic>proprotein convertase subtilisin\/kexin de type 9<\/jats:italic>) dans l\u2019arsenal th\u00e9rapeutique va probablement changer la donne. Ces anticorps permettent non seulement d\u2019am\u00e9liorer la prise en charge des patients porteurs d\u2019hypercholest\u00e9rol\u00e9mie familiale mais \u00e9galement de r\u00e9duire le risque de complications cliniques de l\u2019ath\u00e9roscl\u00e9rose en pr\u00e9vention secondaire apr\u00e8s un infarctus du myocarde, une art\u00e9riopathie p\u00e9riph\u00e9rique ou un accident vasculaire c\u00e9r\u00e9bral isch\u00e9mique. D\u2019autres strat\u00e9gies th\u00e9rapeutiques sont en cours d\u2019investigation, ciblant notamment des cellules et cytokines impliqu\u00e9es dans les r\u00e9ponses immuno-inflammatoires avec pour objectif de pr\u00e9venir les complications de l\u2019ath\u00e9roscl\u00e9rose ou les l\u00e9sions du myocarde au d\u00e9cours d\u2019un infarctus.<\/jats:p>","DOI":"10.1051\/medsci\/2019224","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T08:47:41Z","timestamp":1578300461000},"page":"1014-1016","source":"Crossref","is-referenced-by-count":0,"title":["Place des anticorps th\u00e9rapeutiques dans les maladies cardiovasculaires et m\u00e9taboliques aujourd\u2019hui"],"prefix":"10.1051","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-8092","authenticated-orcid":false,"given":"Denis","family":"Angoulvant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1056\/NEJM199404073301402","volume":"330","author":"Investigators EPIC","year":"1994","journal-title":"N Engl J Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJM197604082941501","volume":"294","author":"Smith","year":"1976","journal-title":"N Engl J Med"},{"key":"R3","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jtcvs.2007.12.062","volume":"136","author":"Testa","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R4","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1161\/hc4801.100236","volume":"104","author":"Baran","year":"2001","journal-title":"Circulation"},{"key":"R5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0002-9149(01)01723-4","volume":"88","author":"Rusnak","year":"2001","journal-title":"Am J Cardiol"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"St\u00e4hli BE, Gebhard C, Duchatelle V, et al. 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