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Les cons\u00e9quences des stress isch\u00e9miques sont dramatiques et peuvent conduire \u00e0 des incapacit\u00e9s organiques, motrices ou cognitives. Actuellement il n\u2019existe aucune cible mol\u00e9culaire identifi\u00e9e dont le ciblage pourrait \u00eatre b\u00e9n\u00e9fique dans ce domaine. La mouche <jats:italic>Drosophila melanogaster,<\/jats:italic> utilis\u00e9e comme animal mod\u00e8le, a conduit \u00e0 une avanc\u00e9e majeure en permettant l\u2019identification d\u2019une toute nouvelle cible pharmacologique dont l\u2019inhibition augmente de fa\u00e7on importante la tol\u00e9rance \u00e0 l\u2019hypoxie. Appliqu\u00e9 \u00e0 un mod\u00e8le pr\u00e9clinique de transplantation r\u00e9nale, cette nouvelle approche am\u00e9liore nettement la reprise fonctionnelle du greffon \u00e0 long terme. Cette revue retrace les \u00e9tapes qui ont permis de transf\u00e9rer chez le mammif\u00e8re sup\u00e9rieur une cible mise en \u00e9vidence chez la drosophile, ce qui montre clairement, au-del\u00e0 de la recherche fondamentale, l\u2019apport que peut apporter un organisme mod\u00e8le \u00e0 la clinique.<\/jats:p>","DOI":"10.1051\/medsci\/2020012","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T12:25:06Z","timestamp":1583411106000},"page":"147-152","source":"Crossref","is-referenced-by-count":0,"title":["Un nouveau paradigme dans le traitement de l\u2019isch\u00e9mie"],"prefix":"10.1051","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8383-9818","authenticated-orcid":false,"given":"Michel","family":"Tauc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"R1","first-page":"64","volume":"54","author":"Ciubotaru","year":"2015","journal-title":"ESR"},{"key":"R2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1177\/1074248417702893","volume":"22","author":"Veighey","year":"2017","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"R3","first-page":"769","volume":"47","author":"Tauc","year":"1955","journal-title":"J Physiol (Paris)"},{"key":"R4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/202145a0","volume":"202","author":"Kandel","year":"1964","journal-title":"Nature"},{"key":"R5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/BJ20050675","volume":"393","author":"Arquier","year":"2006","journal-title":"Biochem J"},{"key":"R6","doi-asserted-by":"crossref","first-page":"e5422","DOI":"10.1371\/journal.pone.0005422","volume":"4","author":"Vigne","year":"2009","journal-title":"PLoS One"},{"key":"R7","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1371\/journal.pone.0000056","volume":"1","author":"Vigne","year":"2006","journal-title":"PLoS One"},{"key":"R8","unstructured":"Barmore W, Stone WL\nPhysiology, urea cycle 2019 ; Treasure Island (FL)\nStatPearls Publishing"},{"key":"R9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1472-6793-8-22","volume":"8","author":"Vigne","year":"2008","journal-title":"BMC Physiol"},{"key":"R10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00726-009-0408-7","volume":"38","author":"Park","year":"2010","journal-title":"Amino Acids"},{"key":"R11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0968-0896(97)10030-X","volume":"6","author":"Lee","year":"1998","journal-title":"Bioorg Med Chem"},{"key":"R12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000362555","volume":"126","author":"Kato","year":"2014","journal-title":"Nephron Exp Nephrol"},{"key":"R13","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1681\/ASN.2016010012","volume":"28","author":"Melis","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1051\/medsci\/200218170","volume":"18","author":"Gothi\u00e9","year":"2002","journal-title":"Med Sci (Paris)"},{"key":"R15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1479-5876-11-129","volume":"11","author":"Rossard","year":"2013","journal-title":"J Transl Med"},{"key":"R16","first-page":"374","volume":"39","author":"Blondeau","year":"2019","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2020012\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T18:52:09Z","timestamp":1595271129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2020012"}},"subtitle":["L\u2019apport de la drosophile"],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":16,"journal-issue":{"issue":"2"},"alternative-id":["msc190311"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2020012","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"type":"print","value":"0767-0974"},{"type":"electronic","value":"1958-5381"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}