{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:01:35Z","timestamp":1769169695501,"version":"3.49.0"},"reference-count":50,"publisher":"EDP Sciences","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Les maladies cardiovasculaires (MCV) sont la premi\u00e8re cause de mortalit\u00e9 dans le monde. Les plaquettes jouent un r\u00f4le majeur dans le d\u00e9veloppement de ces maladies et la mise au point d\u2019antiplaquettaires efficaces constitue une priorit\u00e9 dans le cadre de la lutte contre la mortalit\u00e9 li\u00e9e aux MCV. L\u2019aspirine et les m\u00e9dicaments de la famille des thi\u00e9nopyridines sont les agents antiplaquettaires les plus utilis\u00e9s actuellement. Ces m\u00e9dicaments ciblent des voies de signalisation impliqu\u00e9es dans l\u2019initiation de l\u2019agr\u00e9gation, exer\u00e7ant ainsi un effet antiplaquettaire mod\u00e9r\u00e9. D\u2019autres m\u00e9dicaments aux effets plus importants, comme les mol\u00e9cules dirig\u00e9es contre le r\u00e9cepteur GPIIb\/IIIa, inhibent l\u2019agr\u00e9gation plaquettaire ind\u00e9pendamment de la voie de signalisation initiant l\u2019activation plaquettaire, mais ils sont associ\u00e9s \u00e0 des complications h\u00e9morragiques major\u00e9es. \u00c9tant donn\u00e9es les caract\u00e9ristiques sp\u00e9cifiques de chacun de ces agents antiplaquettaires, leur prescription n\u00e9cessite de prendre en compte le type d\u2019\u00e9v\u00e8nement cardio-vasculaire, l\u2019\u00e2ge et les comorbidit\u00e9s du patient trait\u00e9 et, bien s\u00fbr, les effets secondaires h\u00e9morragiques potentiels de la mol\u00e9cule qui est prescrite. Appara\u00eet donc la n\u00e9cessit\u00e9 de mettre au point de nouvelles mol\u00e9cules ayant un effet plus cibl\u00e9, gardant une efficacit\u00e9 optimale, mais permettant une r\u00e9duction du risque h\u00e9morragique qui constitue la principale limite des m\u00e9dicaments antiplaquettaires.<\/jats:p>","DOI":"10.1051\/medsci\/2020061","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T08:35:11Z","timestamp":1588322111000},"page":"348-357","source":"Crossref","is-referenced-by-count":2,"title":["Antiplaquettaires actuels, en cours de d\u00e9veloppement et cibles th\u00e9rapeutiques"],"prefix":"10.1051","volume":"36","author":[{"given":"Mustapha Zine","family":"El 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