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Bien qu\u2019efficace, l\u2019utilisation des mole\u0301cules conventionnelles est limite\u0301e par leur toxicite\u0301 et par l\u2019e\u0301mergence de re\u0301sistance du virus, rendant ne\u0301cessaire le d\u00e9veloppement de nouveaux traitements. Lors de la r\u00e9plication du CMVH, l\u2019encapsidation de l\u2019ADN est r\u00e9alis\u00e9e par le complexe terminase qui clive l\u2019ADN pour empaqueter le g\u00e9nome dans la capside. L\u2019absence d\u2019homologues dans les cellules des mammif\u00e8res rend les prot\u00e9ines du complexe terminase des cibles id\u00e9ales pour des antiviraux sp\u00e9cifiques. Une nouvelle mol\u00e9cule, le letermovir, cible une \u00e9tape exclusivement virale en interagissant avec le complexe terminase. Son efficacit\u00e9 a \u00e9t\u00e9 prouv\u00e9e lors d\u2019essais cliniques de phase\u00a0III. 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