{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:19:42Z","timestamp":1790356782282,"version":"4.1.0"},"reference-count":30,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Dans les maladies d\u00e9g\u00e9n\u00e9ratives de la r\u00e9tine affectant les photor\u00e9cepteurs, la transplantation de cellules permettant la restauration de la vision est aujourd\u2019hui envisag\u00e9e. La derni\u00e8re d\u00e9cennie a vu des progr\u00e8s remarquables dans la g\u00e9n\u00e9ration de cellules de r\u00e9tine \u00e0 partir de cellules souches pluripotentes humaines avec, en particulier, le d\u00e9veloppement de syst\u00e8mes de culture en trois dimensions (3D) permettant la g\u00e9n\u00e9ration d\u2019organo\u00efdes de r\u00e9tine. Dans cette revue, nous faisons un \u00e9tat des lieux sur les strat\u00e9gies pr\u00e9cliniques men\u00e9es dans des mod\u00e8les animaux pour le remplacement des photor\u00e9cepteurs par des photor\u00e9cepteurs d\u00e9riv\u00e9s de cellules souches et pr\u00e9sentons les obstacles importants qui restent \u00e0 \u00eatre surmont\u00e9s.<\/jats:p>","DOI":"10.1051\/medsci\/2020097","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T09:26:14Z","timestamp":1593681974000},"page":"600-606","source":"Crossref","is-referenced-by-count":5,"title":["Nouvelle approche th\u00e9rapeutique pour les r\u00e9tinites 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