{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T11:55:58Z","timestamp":1648900558491},"reference-count":22,"publisher":"EDP Sciences","issue":"8-9","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Le SARS-CoV-2 (<jats:italic>severe acute respiratory syndrome<\/jats:italic>-<jats:italic>coronavirus-2),<\/jats:italic> qui a \u00e9merg\u00e9 \u00e0 la fin de l\u2019ann\u00e9e 2019 en R\u00e9publique populaire de Chine, est responsable d\u2019une crise sanitaire mondiale qui a entra\u00een\u00e9 le confinement de plus de 3 milliards d\u2019individus et l\u2019arr\u00eat brutal de l\u2019\u00e9conomie plan\u00e9taire. Dans ce contexte, une course contre la montre est lanc\u00e9e afin de d\u00e9velopper, dans les plus brefs d\u00e9lais, un traitement permettant d\u2019enrayer la pand\u00e9mie. Une \u00e9tude de l\u2019\u00e9quipe de Volker Thiel, parue dans le journal <jats:italic>Nature<\/jats:italic>, rapporte la mise au point d\u2019une technique de g\u00e9n\u00e9tique inverse pour le SARS-CoV-2, leur ayant permis de recr\u00e9er le virus en seulement quelques semaines. Les perspectives de ces travaux sont tr\u00e8s int\u00e9ressantes puisqu\u2019elles permettent d\u2019envisager la manipulation g\u00e9n\u00e9tique du virus et ainsi le d\u00e9veloppement d\u2019outils pr\u00e9cieux qui seront utiles pour combattre l\u2019infection. Si la technique repr\u00e9sente \u00e9galement un saut technologique qui permettra d\u2019am\u00e9liorer nos connaissances sur le virus, elle porte aussi en elle le germe d\u2019un possible m\u00e9susage et la cr\u00e9ation d\u2019un virus \u00e0 des fins malveillantes. Les avantages et inconv\u00e9nients de recr\u00e9er le SARS-CoV-2 dans cette p\u00e9riode de pand\u00e9mie sont discut\u00e9s dans cet article.<\/jats:p>","DOI":"10.1051\/medsci\/2020124","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T09:05:08Z","timestamp":1596618308000},"page":"797-802","source":"Crossref","is-referenced-by-count":3,"title":["Une course contre la montre"],"prefix":"10.1051","volume":"36","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Iseni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Nicolas","family":"Tournier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"R2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J Med"},{"key":"R3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"R4","unstructured":"Lescure FX, Bouadma L, Nguyen D, et al. 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