{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:35:18Z","timestamp":1790843718284,"version":"4.1.0"},"reference-count":34,"publisher":"EDP Sciences","issue":"10","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>La d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l\u2019\u00e2ge (DMLA) est une maladie multifactorielle hautement h\u00e9r\u00e9ditaire qui survient chez le sujet \u00e2g\u00e9 et est caus\u00e9e par une combinaison de facteurs de risques g\u00e9n\u00e9tiques et environnementaux. Les formes atrophiques de la maladie constituent aujourd\u2019hui une impasse th\u00e9rapeutique. La physiopathologie de la DMLA est invariablement associ\u00e9e \u00e0 une accumulation dans l\u2019espace sous-r\u00e9tinien, de phagocytes mononucl\u00e9\u00e9s (PM), une famille de cellules qui inclue des macrophages r\u00e9sidents et inflammatoires. Nous aborderons dans cette revue l\u2019ensemble des m\u00e9canismes de cette inflammation sp\u00e9cifique, de l\u2019origine des PM aux cons\u00e9quences de leur accumulation dans l\u2019espace sous-r\u00e9tinien. Finalement, nous discuterons de l\u2019impact des facteurs de risques g\u00e9n\u00e9tiques et environnementaux \u00e9tablis de la DMLA sur le passage d\u2019une inflammation b\u00e9n\u00e9fique aux stades pr\u00e9coces de la maladie \u00e0 une inflammation d\u00e9l\u00e9t\u00e8re aux stades avanc\u00e9s.<\/jats:p>","DOI":"10.1051\/medsci\/2020159","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T10:35:18Z","timestamp":1602066918000},"page":"886-892","source":"Crossref","is-referenced-by-count":11,"title":["Sur les origines inflammatoires de la DMLA"],"prefix":"10.1051","volume":"36","author":[{"given":"Christophe","family":"Roubeix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Alain","family":"Sahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Guillonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Delarasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Sennlaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Wong WL, Su X, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2014; 2.","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"R2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ajo.2003.11.069","volume":"137","author":"Klein","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Querques G, Merle BMJ, Pumariega NM, et al. Dynamic drusen remodelling in participants of the nutritional AMD treatment-2 (NAT-2) randomized trial. PLoS One 2016 ; 11 :","DOI":"10.1371\/journal.pone.0149219"},{"key":"R4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nri1224","volume":"3","author":"Streilein","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"R5","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1172\/JCI31692","volume":"117","author":"Combadi\u00e8re","year":"2007","journal-title":"J Clin Invest"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/emmm.201302692","volume":"5","author":"Sennlaub","year":"2013","journal-title":"EMBO Mol Med"},{"key":"R7","doi-asserted-by":"crossref","first-page":"13568","DOI":"10.1523\/JNEUROSCI.2468-15.2015","volume":"35","author":"Levy","year":"2015","journal-title":"J Neurosci"},{"key":"R8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.immuni.2017.01.006","volume":"46","author":"Calippe","year":"2017","journal-title":"Immunity"},{"key":"R9","doi-asserted-by":"crossref","first-page":"29637","DOI":"10.1074\/jbc.M500922200","volume":"280","author":"Manna","year":"2005","journal-title":"J Biol Chem"},{"key":"R10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15252\/emmm.201404524","volume":"7","author":"Levy","year":"2015","journal-title":"EMBO Mol Med"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Hu SJ, Calippe B, Lavalette S, et al. Upregulation of P2RX7 in Cx3cr1-deficient mononuclear phagocytes leads to increased interleukin-1\u03b2 secretion and photoreceptor neurodegeneration. J Neurosci 2015 ; 35 :","DOI":"10.1523\/JNEUROSCI.3955-14.2015"},{"key":"R12","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.ajpath.2011.01.013","volume":"178","author":"Lavalette","year":"2011","journal-title":"Am J Pathol"},{"key":"R13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1160\/TH08-12-0830","volume":"102","author":"Schweighofer","year":"2009","journal-title":"Thromb Haemost"},{"key":"R14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-019-1655-5","volume":"17","author":"Charles-Messance","year":"2020","journal-title":"J Neuroinflammation"},{"key":"R15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.16490","volume":"5","author":"Eandi","year":"2016","journal-title":"Elife"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Chalam K V., Grover S, Sambhav K, et al. Aqueous interleukin-6 levels are superior to vascular endothelial growth factor in predicting therapeutic response to bevacizumab in age-related macular degeneration. J Ophthalmol 2014; 2014.","DOI":"10.1155\/2014\/502174"},{"key":"R17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15252\/emmm.201404524","volume":"7","author":"Levy","year":"2015","journal-title":"EMBO Mol Med"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1001\/archopht.122.7.1013","volume":"122","author":"Cousins","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"R19","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1167\/iovs.09-4890","volume":"51","author":"Lichtlen","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/acel.12540","volume":"16","author":"Mathis","year":"2017","journal-title":"Aging Cell"},{"key":"R21","doi-asserted-by":"crossref","first-page":"9890","DOI":"10.1523\/JNEUROSCI.1099-13.2013","volume":"33","author":"Housset","year":"2013","journal-title":"J Neurosci"},{"key":"R22","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/aos.12770","volume":"93","author":"Fauser","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"R23","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1167\/iovs.03-0097","volume":"44","author":"Sakurai","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Chakravarthy U, Wong TY, Fletcher A, et al. Clinical risk factors for age-related macular degeneration: A systematic review and meta-analysis. BMC Ophthalmol 2010 ; 10 :","DOI":"10.1186\/1471-2415-10-31"},{"key":"R25","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamaophthalmol.2018.1544","volume":"136","author":"Holz","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"R26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ng.3448","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat Genet"},{"key":"R27","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1167\/iovs.13-12122","volume":"54","author":"Zhao","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaut.2009.12.003","volume":"34","author":"Arnson","year":"2010","journal-title":"J Autoimmun"},{"key":"R29","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1093\/aje\/kwr005","volume":"173","author":"Adams","year":"2011","journal-title":"Am J Epidemiol"},{"key":"R30","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.15252\/emmm.201606531","volume":"8","author":"Andriessen","year":"2016","journal-title":"EMBO Mol Med"},{"key":"R31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep40826","volume":"7","author":"Zinkernagel","year":"2017","journal-title":"Sci Rep"},{"key":"R32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2567.2007.02611.x","volume":"122","author":"Lim","year":"2007","journal-title":"Immunology"},{"key":"R33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/230386","volume":"2012","author":"Tedesco","year":"2012","journal-title":"J Transplant"},{"key":"R34","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/9550","volume":"5","author":"Gilroy","year":"1999","journal-title":"Nat Med."}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2020159\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T10:38:29Z","timestamp":1602067109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2020159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":34,"journal-issue":{"issue":"10"},"alternative-id":["msc200163"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2020159","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}