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Alors que l\u2019ex\u00e9r\u00e8se compl\u00e8te a une valeur pronostique dans certains gliomes de haut grade, les DIPG (<jats:italic>diffuse intrinsic pontine gliomas<\/jats:italic>) ne peuvent en b\u00e9n\u00e9ficier du fait d\u2019une localisation critique au niveau du tronc c\u00e9r\u00e9bral et de leur caract\u00e8re infiltrant. La radioth\u00e9rapie demeure le traitement de r\u00e9f\u00e9rence contre ces tumeurs depuis bient\u00f4t cinquante ans, et les tentatives pour am\u00e9liorer le pronostic vital des patients \u00e0 l\u2019aide de chimioth\u00e9rapies ou de th\u00e9rapies cibl\u00e9es se sont r\u00e9v\u00e9l\u00e9es infructueuses. La connaissance des alt\u00e9rations mol\u00e9culaires dans ces gliomes a fortement progress\u00e9 cette derni\u00e8re d\u00e9cennie, gr\u00e2ce aux progr\u00e8s du s\u00e9quen\u00e7age \u00e0 haut d\u00e9bit. Cela a permis de r\u00e9v\u00e9ler des entit\u00e9s distinctes au niveau mol\u00e9culaire et de pr\u00e9ciser des diagnostics discriminants. Dans cette revue, nous faisons le point sur ces nouvelles connaissances et les perspectives qu\u2019elles apportent en termes de strat\u00e9gies cliniques.<\/jats:p>","DOI":"10.1051\/medsci\/2020279","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T20:22:56Z","timestamp":1613506976000},"page":"159-166","source":"Crossref","is-referenced-by-count":5,"title":["L\u2019art de la guerre appliqu\u00e9 aux 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