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Cette fonction est coordonn\u00e9e avec l\u2019\u00e9limination des d\u00e9chets du m\u00e9tabolisme, impliquant la production par les reins d\u2019environ 180 litres de filtrat par jour et la r\u00e9absorption de la grande majorit\u00e9 de l\u2019eau et des solut\u00e9s filtr\u00e9s. L\u2019ajustement final de la composition de l\u2019urine est r\u00e9alis\u00e9 dans le segment distal sensible \u00e0 l\u2019aldost\u00e9rone (ASDN), qui inclut le tube contourn\u00e9 distal et le syst\u00e8me collecteur. La r\u00e9absorption de sodium pr\u00e9domine dans le tube distal si le potassium doit \u00eatre \u00e9pargn\u00e9, ou dans le syst\u00e8me collecteur si le potassium doit \u00eatre s\u00e9cr\u00e9t\u00e9. Le syndrome n\u00e9phrotique est caract\u00e9ris\u00e9 par une prot\u00e9inurie massive caus\u00e9e par des l\u00e9sions glom\u00e9rulaires, associ\u00e9e \u00e0 une r\u00e9tention hydrosod\u00e9e prenant place dans l\u2019ASDN et induisant chez le patient des \u0153d\u00e8mes parfois volumineux.<\/jats:p>","DOI":"10.1051\/medsci\/2021032","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T08:07:57Z","timestamp":1619597277000},"page":"359-365","source":"Crossref","is-referenced-by-count":0,"title":["R\u00f4le du n\u00e9phron distal dans le contr\u00f4le du volume extracellulaire en condition physiologique et dans le syndrome 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