{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:59:39Z","timestamp":1757779179829},"reference-count":42,"publisher":"EDP Sciences","issue":"4","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>La survie d\u2019une esp\u00e8ce d\u00e9pend de deux processus intimement li\u00e9s : la reproduction, d\u2019une part, et l\u2019\u00e9quilibre entre les besoins \u00e9nerg\u00e9tiques et l\u2019approvisionnement en sources d\u2019\u00e9nergie par l\u2019alimentation, d\u2019autre part. Ces deux processus sont contr\u00f4l\u00e9s dans le cerveau par l\u2019hypothalamus, qui produit des neurohormones agissant sur l\u2019hypophyse pour piloter diverses fonctions physiologiques. L\u2019une de ces neurohormones, la GnRH, contr\u00f4le non seulement la maturation et le fonctionnement des organes reproducteurs, incluant les ovaires et les testicules, lors de la pubert\u00e9 et \u00e0 l\u2019\u00e2ge adulte, mais aussi l\u2019attirance sexuelle. De r\u00e9centes d\u00e9couvertes sugg\u00e8rent que la signalisation impliquant la neuropiline-1 dans les neurones s\u00e9cr\u00e9tant la GnRH jouerait un r\u00f4le charni\u00e8re dans la coordination du neurod\u00e9veloppement et des adaptations physiologiques et comportementales n\u00e9cessaires au d\u00e9clenchement de la pubert\u00e9 et \u00e0 l\u2019acquisition de la fonction de reproduction. Dans cet article de synth\u00e8se, nous repla\u00e7ons ces d\u00e9couvertes dans le contexte de r\u00e9cents travaux montrant que les voies de signalisation des s\u00e9maphorines de classe 3 sont impliqu\u00e9es dans la physiopathologie non seulement de l\u2019infertilit\u00e9, mais aussi de l\u2019ob\u00e9sit\u00e9. Nous discutons \u00e9galement l\u2019implication potentielle des neurones produisant la GnRH dans la perception des odeurs sociales et dans la pr\u00e9cocit\u00e9 de la maturation sexuelle. L\u2019hypoth\u00e8se selon laquelle l\u2019activit\u00e9 de ces neurones au cours du d\u00e9veloppement postnatal constituerait le cha\u00eenon manquant entre la prise de poids, le d\u00e9clenchement de la pubert\u00e9 et le comportement sexuel, ouvre la voie \u00e0 une meilleure compr\u00e9hension de l\u2019implication de l\u2019hom\u00e9ostasie \u00e9nerg\u00e9tique dans la maturation sexuelle, et pourrait aussi avoir des implications th\u00e9rapeutiques pour la pubert\u00e9 pr\u00e9coce.<\/jats:p>","DOI":"10.1051\/medsci\/2021035","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T08:07:57Z","timestamp":1619597277000},"page":"366-371","source":"Crossref","is-referenced-by-count":1,"title":["Signalisation impliquant la neuropiline dans les neurones s\u00e9cr\u00e9tant la GnRH"],"prefix":"10.1051","volume":"37","author":[{"given":"Charlotte","family":"Vanacker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien G.","family":"Bouret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Giacobini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Pr\u00e9vot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrendo.2015.112","volume":"11","author":"Boehm","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1210\/er.2018-00248","volume":"40","author":"Howard","year":"2019","journal-title":"Endocr Rev"},{"key":"R3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1210\/er.2002-0019","volume":"24","author":"Parent","year":"2003","journal-title":"Endocr Rev"},{"key":"R4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/338161a0","volume":"338","author":"Schwanzel-Fukuda","year":"1989","journal-title":"Nature"},{"key":"R5","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.86.20.8132","volume":"86","author":"Wray","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"R6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000431021","volume":"102","author":"Giacobini","year":"2015","journal-title":"Neuroendocrinology"},{"key":"R7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1126\/science.1173596","volume":"325","author":"Imai","year":"2009","journal-title":"Science"},{"key":"R8","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1242\/dev.139444","volume":"143","author":"Casoni","year":"2016","journal-title":"Development"},{"key":"R9","doi-asserted-by":"crossref","first-page":"e104633","DOI":"10.15252\/embj.2020104633","volume":"39","author":"Vanacker","year":"2020","journal-title":"EMBO J"},{"key":"R10","doi-asserted-by":"crossref","first-page":"e1002896","DOI":"10.1371\/journal.pgen.1002896","volume":"8","author":"Hanchate","year":"2012","journal-title":"PLoS Genet"},{"key":"R11","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/hmg\/ddx080","volume":"26","author":"Marcos","year":"2017","journal-title":"Hum Mol Genet"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Kotan LD, Ternier G, Cakir AD, et al. 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