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Ce virus, d\u00e9couvert au Kenya en 1930, est consid\u00e9r\u00e9 par l\u2019Organisation mondiale de la sant\u00e9 comme pr\u00e9sentant un risque important de provoquer de vastes \u00e9pid\u00e9mies. Les moyens d\u00e9di\u00e9s \u00e0 la lutte contre le VFVR restent toutefois particuli\u00e8rement limit\u00e9s et le virus est mal connu. Dans cette Synth\u00e8se, nous nous attacherons \u00e0 pr\u00e9senter ce virus avant de nous int\u00e9resser plus sp\u00e9cifiquement \u00e0 son facteur de virulence, la prot\u00e9ine NSs. Nous discuterons la capacit\u00e9 de cette prot\u00e9ine virale \u00e0 former des fibrilles de type amylo\u00efde et son implication dans la neurotoxicit\u00e9 du virus chez les animaux infect\u00e9s.<\/jats:p>","DOI":"10.1051\/medsci\/2021090","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T08:10:47Z","timestamp":1624867847000},"page":"601-608","source":"Crossref","is-referenced-by-count":3,"title":["Le virus de la fi\u00e8vre de la vall\u00e9e du Rift et son \u00e9tonnante prot\u00e9ine NSs"],"prefix":"10.1051","volume":"37","author":[{"given":"Psylvia","family":"L\u00e9ger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-1452","authenticated-orcid":false,"given":"Pierre-Yves","family":"Lozach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/path.1700340418","volume":"34","author":"Daubney","year":"1931","journal-title":"J Pathol Bacteriol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1099\/jgv.0.001296","volume":"100","author":"Wright","year":"2019","journal-title":"J Gen Virol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1099\/jgv.0.000765","volume":"98","author":"Lumley","year":"2017","journal-title":"J Gen Virol"},{"key":"R4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/zph.12153","volume":"62","author":"Peyre","year":"2015","journal-title":"Zoonoses Public Health"},{"key":"R5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-ento-010715-023819","volume":"61","author":"Linthicum","year":"2016","journal-title":"Annu Rev Entomol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1038\/s41467-020-17101-y","volume":"11","author":"Leger","year":"2020","journal-title":"Nat Commun"},{"key":"R7","doi-asserted-by":"crossref","first-page":"10341","DOI":"10.1128\/JVI.01191-08","volume":"82","author":"Freiberg","year":"2008","journal-title":"J Virol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2217\/fvl.15.52","volume":"10","author":"L\u00e9ger","year":"2015","journal-title":"Future Virol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3390\/v8060174","volume":"8","author":"Wuerth","year":"2016","journal-title":"Viruses"},{"key":"R10","doi-asserted-by":"crossref","first-page":"13767","DOI":"10.1128\/JVI.01364-12","volume":"86","author":"De Boer","year":"2012","journal-title":"J Virol"},{"key":"R11","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1128\/JVI.02055-15","volume":"90","author":"Riblett","year":"2016","journal-title":"J Virol"},{"key":"R12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/tra.12393","volume":"17","author":"Leger","year":"2016","journal-title":"Traffic"},{"key":"R13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.chom.2011.06.007","volume":"10","author":"Lozach","year":"2011","journal-title":"Cell Host Microbe"},{"key":"R14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1051\/medsci\/2012281005","volume":"28","author":"Meier","year":"2012","journal-title":"Med Sci (Paris)"},{"key":"R15","doi-asserted-by":"crossref","first-page":"13642","DOI":"10.1128\/JVI.01973-12","volume":"86","author":"de Boer","year":"2012","journal-title":"J Virol"},{"key":"R16","first-page":"176","volume":"23","author":"Uckeley","year":"2019","journal-title":"Cell biology of phlebovirus entry. 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