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L\u2019activation aigu\u00eb de l\u2019axe HPA est fondamentale pour la r\u00e9ponse <jats:italic>fight or flight<\/jats:italic> (\u00ab combats ou fuis \u00bb). Elle permet de mobiliser un maximum d\u2019\u00e9nergie pour un effort, tout en effa\u00e7ant la fatigue. En revanche, son activation chronique diminue l\u2019efficacit\u00e9 musculaire et entra\u00eene une fatigue chronique. On discutera dans cette partie de plusieurs points strat\u00e9giques \u00e0 consid\u00e9rer pour tenter de comprendre et de traiter ensemble inflammation et fatigue chroniques.<\/jats:p>","DOI":"10.1051\/medsci\/2021170","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T09:26:25Z","timestamp":1638350785000},"page":"1047-1054","source":"Crossref","is-referenced-by-count":4,"title":["M\u00e9canismes sous-jacents \u00e0 la fatigue chronique, un sympt\u00f4me trop souvent n\u00e9glig\u00e9"],"prefix":"10.1051","volume":"37","author":[{"given":"Alain","family":"Trautmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2967\/jnumed.113.131045","volume":"55","author":"Nakatomi","year":"2014","journal-title":"J Nucl Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s12967-020-02533-3","volume":"18","author":"Sweetman","year":"2020","journal-title":"J Transl Med"},{"key":"R3","first-page":"91","volume":"13","author":"Olson","year":"2010","journal-title":"Anti-Aging Therapeutics 2010 Conference Year"},{"key":"R4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-2999(03)01285-8","volume":"463","author":"Carrasco","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"R5","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0306-4530(01)00099-3","volume":"27","author":"Goebel","year":"2002","journal-title":"Psychoneuroendocrinol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pain.2010.05.031","volume":"150","author":"Rivat","year":"2010","journal-title":"Pain"},{"key":"R7","doi-asserted-by":"crossref","first-page":"44779","DOI":"10.18632\/oncotarget.8242","volume":"7","author":"Trautmann","year":"2016","journal-title":"Oncotarget"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1176\/appi.ajp.160.9.1554","volume":"160","author":"Raison","year":"2003","journal-title":"Am J Psychiatry"},{"key":"R9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1071\/HC19041","volume":"11","author":"Mackay","year":"2019","journal-title":"J Prim Health Care"},{"key":"R10","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1007\/s12035-018-0928-9","volume":"55","author":"Monro","year":"2018","journal-title":"Mol Neurobiol"},{"key":"R11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00281-018-0673-1","volume":"40","author":"Sousa-Valente","year":"2018","journal-title":"Semin Immunopathol"},{"key":"R12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol"},{"key":"R13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Guedj E, Campion JY, Dudouet P, et al. 18F-FDG brain PET hypometabolism in patients with long Covid. 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