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Ces VE v\u00e9hiculent du mat\u00e9riel biologique (prot\u00e9ines, lipides, acides nucl\u00e9iques) qu\u2019elles peuvent transf\u00e9rer \u00e0 des cellules\/tissus cibles, modulant ainsi leur r\u00e9ponse et\/ou leur ph\u00e9notype. Les dysfonctions caract\u00e9risant les maladies m\u00e9taboliques li\u00e9es \u00e0 l\u2019ob\u00e9sit\u00e9 sont associ\u00e9es \u00e0 des modifications des concentrations circulantes de VE ainsi qu\u2019\u00e0 des alt\u00e9rations de leur contenu. L\u2019int\u00e9r\u00eat grandissant port\u00e9 aux VE comme nouveaux vecteurs de communication intercellulaire a conduit \u00e0 s\u2019interroger sur leur r\u00f4le dans le d\u00e9veloppement des complications m\u00e9taboliques. Dans cette synth\u00e8se, nous r\u00e9sumerons la litt\u00e9rature portant sur les VE circulantes comme potentiels marqueurs des maladies m\u00e9taboliques. Nous d\u00e9taillerons ensuite le dialogue v\u00e9siculaire inter-organes responsable du d\u00e9veloppement des complications associ\u00e9es \u00e0 l\u2019ob\u00e9sit\u00e9. Enfin, nous discuterons les futures pistes de recherche qui contribueront \u00e0 mieux appr\u00e9hender le lien entre VE et maladies m\u00e9taboliques.<\/jats:p>","DOI":"10.1051\/medsci\/2021209","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T09:05:12Z","timestamp":1639991112000},"page":"1125-1132","source":"Crossref","is-referenced-by-count":3,"title":["V\u00e9sicules extracellulaires et maladies m\u00e9taboliques"],"prefix":"10.1051","volume":"37","author":[{"given":"Alexia","family":"Blandin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-2422","authenticated-orcid":false,"given":"Soazig","family":"Le Lay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Alberti G, Zimmet P. 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