{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:43:52Z","timestamp":1773103432826,"version":"3.50.1"},"reference-count":38,"publisher":"EDP Sciences","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["465482\/2014-7"],"award-info":[{"award-number":["465482\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Le syndrome des ovaires polykystiques (SOPK) est une endocrinopathie fr\u00e9quente, affectant entre 8 et 13 % des femmes en \u00e2ge de procr\u00e9er. Elle se caract\u00e9rise par une hyperandrog\u00e9nie, une anovulation chronique, et une morphologie polykystique des ovaires. Les femmes qui en sont atteintes ont aussi une pr\u00e9valence plus \u00e9lev\u00e9e d\u2019ob\u00e9sit\u00e9, de troubles m\u00e9taboliques, et un risque accru de diab\u00e8te, d\u2019hypertension art\u00e9rielle syst\u00e9mique et de dyslipid\u00e9mie. Le traitement, en premi\u00e8re intention, de la femme atteinte du SOPK, en l\u2019absence de projet de grossesse \u00e0 court terme, consiste en des modifications du mode de vie et en des contraceptions orales combin\u00e9es offrant, en plus de la contraception, la protection de l\u2019endom\u00e8tre et la r\u00e9duction de l\u2019hyperandrog\u00e9nie. Les contraceptions progestatives seules sont recommand\u00e9es pour les femmes ayant des contre-indications aux estrog\u00e8nes qui sont contenus dans les contraceptifs oraux combin\u00e9s. Des soins esth\u00e9tiques peuvent aussi \u00eatre associ\u00e9s au traitement pharmacologique, en cas d\u2019hirsutisme. Les cas les plus graves peuvent n\u00e9cessiter des m\u00e9dicaments anti-androg\u00e8nes qui seront associ\u00e9s \u00e0 la contraception. Pour les patientes en surpoids et ayant des facteurs de risque cardiom\u00e9taboliques, notamment une r\u00e9sistance \u00e0 l\u2019insuline ou une hyperglyc\u00e9mie, la metformine peut \u00eatre associ\u00e9e \u00e0 la contraception. Le choix de la contraception chez ces femmes repose donc sur une approche adapt\u00e9e aux besoins individuels de chaque patiente.<\/jats:p>","DOI":"10.1051\/medsci\/2022002","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T08:53:41Z","timestamp":1645174421000},"page":"177-181","source":"Crossref","is-referenced-by-count":3,"title":["Contraception dans le contexte du syndrome des ovaires polykystiques"],"prefix":"10.1051","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-7688","authenticated-orcid":false,"given":"Poli Mara","family":"Spritzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"key":"R2","first-page":"19","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"key":"R3","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum Reprod"},{"key":"R4","doi-asserted-by":"crossref","first-page":"R219","DOI":"10.1530\/REP-14-0435","volume":"149","author":"Spritzer","year":"2015","journal-title":"Reproduction"},{"key":"R5","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/humrep\/dex030","volume":"32","author":"Ollila","year":"2017","journal-title":"Hum Reprod"},{"key":"R6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.fertnstert.2018.11.034","volume":"111","author":"Marchesan","year":"2019","journal-title":"Fertil Steril"},{"key":"R7","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"R8","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmu012","volume":"20","author":"Barry","year":"2014","journal-title":"Hum Reprod Update"},{"key":"R9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.atherosclerosis.2007.03.002","volume":"196","author":"Charitidou","year":"2008","journal-title":"Atheroscler"},{"key":"R10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","volume":"10","author":"Teede","year":"2018","journal-title":"Fertil Steril"},{"key":"R11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil Steril"},{"key":"R12","unstructured":"World Health Organization. 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