{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:06:14Z","timestamp":1790831174947,"version":"4.1.0"},"reference-count":57,"publisher":"EDP Sciences","issue":"3","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["FDM201806005916"],"award-info":[{"award-number":["FDM201806005916"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>La succinate d\u00e9shydrog\u00e9nase (SDH) est une enzyme mitochondriale qui participe au cycle de Krebs et \u00e0 la cha\u00eene respiratoire. Quand elles sont \u00e0 l\u2019origine de cancers, les mutations des g\u00e8nes codant les diff\u00e9rentes sous-unit\u00e9s de la SDH sont responsables d\u2019une pr\u00e9disposition aux ph\u00e9ochromocytomes et aux paragangliomes, et, plus rarement, aux tumeurs stromales gastro-intestinales ou au cancer du rein. Une diminution de l\u2019activit\u00e9 de la SDH, non expliqu\u00e9e par la g\u00e9n\u00e9tique, s\u2019observe aussi dans certains cancers plus fr\u00e9quents. Une des cons\u00e9quences de l\u2019inactivation de la SDH est la production excessive de son substrat, le succinate, qui joue un r\u00f4le d\u2019oncom\u00e9tabolite en promouvant un statut pseudohypoxique et d\u2019importants remaniements \u00e9pig\u00e9n\u00e9tiques. La compr\u00e9hension de l\u2019oncogen\u00e8se li\u00e9e \u00e0 la succinate d\u00e9shydrog\u00e9nase permet aujourd\u2019hui de d\u00e9velopper des m\u00e9thodes diagnostiques innovantes et d\u2019envisager des th\u00e9rapies cibl\u00e9es pour la prise en charge des patients atteints.<\/jats:p>","DOI":"10.1051\/medsci\/2022024","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T08:53:36Z","timestamp":1648198416000},"page":"255-262","source":"Crossref","is-referenced-by-count":3,"title":["R\u00f4le de la succinate d\u00e9shydrog\u00e9nase dans le cancer"],"prefix":"10.1051","volume":"38","author":[{"given":"Sophie","family":"Moog","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Favier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ng1095-144","volume":"11","author":"Bourgeron","year":"1995","journal-title":"Nat Genet"},{"key":"R2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"R3","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","volume":"287","author":"Baysal","year":"2000","journal-title":"Science"},{"key":"R4","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1097\/HJH.0000000000002438","volume":"38","author":"Lenders","year":"2020","journal-title":"J Hypertens"},{"key":"R5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrendo.2014.188","volume":"11","author":"Favier","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1530\/ERC-14-0537","volume":"22","author":"Ni","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"R7","doi-asserted-by":"crossref","first-page":"E1386","DOI":"10.1210\/jc.2015-2689","volume":"100","author":"Niemeijer","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"R8","doi-asserted-by":"crossref","first-page":"E357","DOI":"10.1210\/jc.2011-1179","volume":"97","author":"Xekouki","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"R9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1530\/ERC-14-0254","volume":"21","author":"Haller","year":"2014","journal-title":"Endocr Relat Cancer"},{"key":"R10","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/ng.3101","volume":"46","author":"Weinhold","year":"2014","journal-title":"Nat Genet"},{"key":"R11","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cmet.2013.04.019","volume":"17","author":"Sciacovelli","year":"2013","journal-title":"Cell Metab"},{"key":"R12","doi-asserted-by":"crossref","first-page":"e0224132","DOI":"10.1371\/journal.pone.0224132","volume":"14","author":"B\u00e9nit","year":"2019","journal-title":"PLoS One"},{"key":"R13","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/ijc.29080","volume":"135","author":"Morin","year":"2014","journal-title":"Int J Cancer"},{"key":"R14","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1086\/324413","volume":"69","author":"Gimenez-Roqueplo","year":"2001","journal-title":"Am J Hum Genet"},{"key":"R15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1530\/ERC-15-0099","volume":"22","author":"Kim","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"R16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/jmedgenet-2016-104297","volume":"54","author":"Burnichon","year":"2017","journal-title":"J Med Genet"},{"key":"R17","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1210\/jc.2007-0709","volume":"92","author":"Amar","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R18","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1210\/jc.2018-01968","volume":"104","author":"Hescot","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"R19","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1210\/jc.2008-2504","volume":"94","author":"Burnichon","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"R20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1073\/pnas.1009199108","volume":"108","author":"Janeway","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R21","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jnci\/djn254","volume":"100","author":"Ricketts","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"R22","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41568-020-00303-3","volume":"20","author":"Losman","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"R23","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"R24","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"R25","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"issue":"9","key":"R26","doi-asserted-by":"crossref","first-page":"e7094","DOI":"10.1371\/journal.pone.0007094","volume":"4","author":"Favier","year":"2009","journal-title":"PLoS ONE"},{"key":"R27","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1086\/324413","volume":"69","author":"Gimenez-Roqueplo","year":"2001","journal-title":"Am J Hum Genet"},{"key":"R28","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1093\/hmg\/ddi359","volume":"14","author":"Briere","year":"2005","journal-title":"Hum Mol Genet"},{"key":"R29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","volume":"7","author":"Selak","year":"2005","journal-title":"Cancer Cell"},{"key":"R30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1371\/journal.pgen.0010008","volume":"1","author":"Dahia","year":"2005","journal-title":"PLoS Genet"},{"key":"R31","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/hmg\/ddq206","volume":"19","author":"Burnichon","year":"2010","journal-title":"Hum Mol Genet"},{"key":"R32","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1016\/j.celrep.2020.03.022","volume":"30","author":"Morin","year":"2020","journal-title":"Cell Rep"},{"key":"R33","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1530\/ERC-20-0205","volume":"27","author":"Bechmann","year":"2020","journal-title":"Endocr Relat Cancer"},{"key":"R34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/cancers13030385","volume":"13","author":"Seifert","year":"2021","journal-title":"Cancers (Basel)"},{"key":"R35","doi-asserted-by":"crossref","first-page":"E954","DOI":"10.1210\/jc.2011-3437","volume":"97","author":"Loriot","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"R36","doi-asserted-by":"crossref","first-page":"32955","DOI":"10.18632\/oncotarget.5106","volume":"6","author":"Loriot","year":"2015","journal-title":"Oncotarget"},{"key":"R37","doi-asserted-by":"crossref","first-page":"C9","DOI":"10.1530\/ERC-16-0479","volume":"24","author":"Toledo","year":"2017","journal-title":"Endocr Relat Cancer"},{"key":"R38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","volume":"23","author":"Letouze","year":"2013","journal-title":"Cancer Cell"},{"key":"R39","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1158\/2159-8290.CD-13-0092","volume":"3","author":"Killian","year":"2013","journal-title":"Cancer Discov"},{"key":"R40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1677\/ERC-10-0211","volume":"18","author":"Eisenhofer","year":"2011","journal-title":"Endocr Relat Cancer"},{"key":"R41","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41588-018-0170-4","volume":"50","author":"Sulkowski","year":"2018","journal-title":"Nat Genet"},{"key":"R42","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/ncb3233","volume":"17","author":"Cardaci","year":"2015","journal-title":"Nat Cell Biol"},{"key":"R43","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1038\/ncomms9784","volume":"6","author":"Lussey-Lepoutre","year":"2015","journal-title":"Nat Commun"},{"key":"R44","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1158\/0008-5472.CAN-20-2936","volume":"81","author":"Goncalves","year":"2021","journal-title":"Cancer Res"},{"key":"R45","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1158\/1078-0432.CCR-19-2335","volume":"26","author":"Liu","year":"2020","journal-title":"Clin Cancer Res"},{"key":"R46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41568-019-0135-7","volume":"19","author":"Ngo","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"R47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.molcel.2019.10.023","volume":"77","author":"Wu","year":"2020","journal-title":"Mol Cell"},{"key":"R48","doi-asserted-by":"crossref","first-page":"13174","DOI":"10.18632\/oncotarget.14485","volume":"8","author":"Mu","year":"2017","journal-title":"Oncotarget"},{"key":"R49","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.annpat.2020.01.010","volume":"40","author":"Broudin","year":"2020","journal-title":"Ann Pathol"},{"key":"R50","doi-asserted-by":"crossref","first-page":"38777","DOI":"10.18632\/oncotarget.6091","volume":"6","author":"Hoekstra","year":"2015","journal-title":"Oncotarget"},{"key":"R51","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1210\/jc.2014-2151","volume":"99","author":"Richter","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"R52","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1158\/1078-0432.CCR-15-1576","volume":"22","author":"Lussey-Lepoutre","year":"2016","journal-title":"Clin Cancer Res"},{"key":"R53","doi-asserted-by":"crossref","first-page":"M1","DOI":"10.1530\/ERC-15-0246","volume":"22","author":"Varoquaux","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"R54","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1007\/s00259-019-04633-9","volume":"47","author":"Lussey-Lepoutre","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"R55","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1002\/ijc.28913","volume":"135","author":"Hadoux","year":"2014","journal-title":"Int J Cancer"},{"key":"R56","doi-asserted-by":"crossref","first-page":"R451","DOI":"10.1530\/ERC-20-0346","volume":"27","author":"Moog","year":"2020","journal-title":"Endocr Relat Cancer"},{"key":"R57","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/jc.2018-02411","volume":"104","author":"Buffet","year":"2019","journal-title":"J Clin Endocrinol Metab"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2022024\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T08:55:13Z","timestamp":1648198513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2022024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":57,"journal-issue":{"issue":"3"},"alternative-id":["msc200647"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2022024","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}