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De concert avec son ligand naturel, la chimiokine CXCL12, cet axe de signalisation joue un r\u00f4le important dans la biologie des lymphocytes B, des stades pr\u00e9coces de diff\u00e9renciation dans la moelle osseuse \u00e0 leur activation et diff\u00e9renciation en cellules s\u00e9cr\u00e9trices d\u2019anticorps, aussi appel\u00e9es plasmocytes. Des mutations gain de fonction de <jats:italic>CXCR4<\/jats:italic> sont retrouv\u00e9es dans une immunod\u00e9ficience rare, le Syndrome WHIM. Ces mutations affectent le m\u00e9canisme de d\u00e9sensibilisation du r\u00e9cepteur et entra\u00eenent un gain de fonction en r\u00e9ponse \u00e0 CXCL12. Cette revue r\u00e9sume le r\u00f4le de CXCR4 dans la r\u00e9ponse immune humorale et, \u00e0 travers l\u2019\u00e9tude du Syndrome WHIM, souligne le r\u00f4le r\u00e9gulateur essentiel de la d\u00e9sensibilisation de CXCR4 dans ces processus. Des travaux r\u00e9cents rapportent en effet qu\u2019une signalisation correcte de CXCR4 est essentielle pour limiter la r\u00e9ponse immune dite \u00ab extra-folliculaire \u00bb et pour permettre une protection au long terme assur\u00e9e par les anticorps.<\/jats:p>","DOI":"10.1051\/medsci\/2022192","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T09:01:32Z","timestamp":1674550892000},"page":"23-30","source":"Crossref","is-referenced-by-count":1,"title":["La signalisation de CXCR4, un rh\u00e9ostat de la r\u00e9ponse immunitaire \u00e0 m\u00e9diation humorale"],"prefix":"10.1051","volume":"39","author":[{"given":"M\u00e9lanie","family":"Khamyath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Bonaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Balabanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5005-1664","authenticated-orcid":false,"given":"Marion","family":"Esp\u00e9li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ajh.23433","volume":"88","author":"Bam","year":"2013","journal-title":"Am J Hematol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/382635a0","volume":"382","author":"Nagasawa","year":"1996","journal-title":"Nature"},{"key":"R3","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.95.16.9448","volume":"95","author":"Ma","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Tashiro K, Nakano T, Honjo T. 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