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Malgr\u00e9 la multitude d\u2019\u00e9tudes visant \u00e0 comprendre les m\u00e9canismes physiologiques qui sous-tendent cette pathologie, la physiopathologie de la sarcop\u00e9nie reste encore mal comprise. A ce jour, il n\u2019existe pas de traitement pharmacologique pour lutter contre cette pathologie. Dans ce contexte, notre \u00e9quipe d\u00e9veloppe des approches th\u00e9rapeutiques bas\u00e9es sur l\u2019utilisation de la prot\u00e9ine GDF5 pour contrecarrer la perte de la masse et de la fonction musculaire dans diverses conditions pathologiques dont la sarcop\u00e9nie. 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