{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T06:14:04Z","timestamp":1750227244063},"reference-count":39,"publisher":"EDP Sciences","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Les maladies auto-immunes (MAI) restent une \u00e9nigme dans notre compr\u00e9hension du syst\u00e8me immunitaire. L\u2019identification de leurs \u00e9tiologies demeure un d\u00e9fi majeur en d\u00e9pit d\u2019une augmentation exponentielle de nos connaissances sur le fonctionnement du syst\u00e8me immunitaire. La cavit\u00e9 orale a une place particuli\u00e8re vis-\u00e0-vis des MAI. La muqueuse buccale pr\u00e9sente les barri\u00e8res naturelles de l\u2019organisme parmi les plus expos\u00e9es \u00e0 des agents pathog\u00e8nes. \u00c0 ce titre, elles jouent un r\u00f4le dans l\u2019\u00e9ducation du syst\u00e8me immunitaire, puis dans la protection quotidienne de l\u2019organisme. Les perturbations du syst\u00e8me immunitaire se manifestent fr\u00e9quemment par des cons\u00e9quences au niveau de la sph\u00e8re buccale, le plus souvent pr\u00e9cocement, permettant d\u2019initier une d\u00e9marche diagnostique. L\u2019effort de recherche actuel sur les interactions entre microbiotes et syst\u00e8me immunitaire permet de moderniser l\u2019hypoth\u00e8se historique liant une origine infectieuse \u00e0 l\u2019apparition de l\u2019auto-immunit\u00e9, en y apportant quelques nuances.<\/jats:p>","DOI":"10.1051\/medsci\/2023195","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T09:03:15Z","timestamp":1706778195000},"page":"49-56","source":"Crossref","is-referenced-by-count":1,"title":["Auto-immunit\u00e9 et cavit\u00e9 orale, o\u00f9 en est-on en 2023 ?"],"prefix":"10.1051","volume":"40","author":[{"given":"Vanessa Dominique","family":"Lobognon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-\u00c9ric","family":"Alard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"591255","DOI":"10.3389\/fimmu.2020.591255","volume":"11","author":"Su\u00e1rez","year":"2020","journal-title":"Front Immunol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/joim.12395","volume":"278","author":"Wang","year":"2015","journal-title":"J Intern Med"},{"key":"R3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41579-020-0367-2","volume":"18","author":"Ruff","year":"2020","journal-title":"Nat Rev Microbiol"},{"key":"R4","first-page":"1","volume":"1","author":"Claessens","year":"2013","journal-title":"Collection de la SFMU"},{"key":"R5","doi-asserted-by":"crossref","first-page":"6061825","DOI":"10.1155\/2018\/6061825","volume":"2018","author":"Saccucci","year":"2018","journal-title":"J Immunol Res"},{"key":"R6","first-page":"381","volume":"127","author":"Vaillant","year":"2000","journal-title":"Annales de dermatologie et de v\u00e9n\u00e9r\u00e9ologie"},{"key":"R7","doi-asserted-by":"crossref","first-page":"615192","DOI":"10.3389\/fimmu.2020.615192","volume":"11","author":"Bach","year":"2021","journal-title":"Front Immunol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/cei.13158","volume":"195","author":"De Luca","year":"2019","journal-title":"Clin Exp Immunol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"R10","doi-asserted-by":"crossref","first-page":"e1009176","DOI":"10.1371\/journal.ppat.1009176","volume":"16","author":"Ortiz Wilczy\u00f1ski","year":"2020","journal-title":"PLoS Pathog"},{"key":"R11","doi-asserted-by":"crossref","first-page":"eaat0797","DOI":"10.1126\/scitranslmed.aat0797","volume":"10","author":"Dutzan","year":"2018","journal-title":"Sci Transl Med"},{"key":"R12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1379\/1466-1268(2000)005<0337:AACCIH>2.0.CO;2","volume":"5","author":"Yokota","year":"2000","journal-title":"Cell Stress Chaperones"},{"key":"R13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fped.2016.00096","volume":"4","author":"Miller","year":"2016","journal-title":"Front Pediat"},{"key":"R14","doi-asserted-by":"crossref","first-page":"ftaa024","DOI":"10.1093\/femspd\/ftaa024","volume":"78","author":"Kobayashi","year":"2020","journal-title":"Pathog Dis"},{"key":"R15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.aan4526","volume":"358","author":"Atarashi","year":"2017","journal-title":"Science"},{"key":"R16","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.3390\/biomedicines10081803","volume":"10","author":"Giordano-Kelhoffer","year":"2022","journal-title":"Biomedicines"},{"key":"R17","doi-asserted-by":"crossref","first-page":"31119","DOI":"10.3402\/jom.v8.31119","volume":"8","author":"Siddiqui","year":"2016","journal-title":"J Oral Microbiol"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3390\/v14071474","volume":"14","author":"Otsuka","year":"2022","journal-title":"Viruses"},{"key":"R19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/1756-185X.14154","volume":"24","author":"Masuko","year":"2021","journal-title":"Int J Rheum Dis"},{"key":"R20","doi-asserted-by":"crossref","first-page":"980805","DOI":"10.3389\/fimmu.2022.980805","volume":"13","author":"Krutyholowa","year":"2022","journal-title":"Front Immunol"},{"key":"R21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00784-015-1556-7","volume":"20","author":"Laugisch","year":"2016","journal-title":"Clin Oral invest"},{"key":"R22","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"R23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrrheum.2009.28","volume":"5","author":"De Pablo","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"R24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","volume":"13","author":"Potempa","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"R25","doi-asserted-by":"crossref","first-page":"e1003627","DOI":"10.1371\/journal.ppat.1003627","volume":"9","author":"Maresz","year":"2013","journal-title":"PLoS Pathog"},{"key":"R26","doi-asserted-by":"crossref","first-page":"e100838","DOI":"10.1371\/journal.pone.0100838","volume":"9","author":"Gully","year":"2014","journal-title":"PLoS One"},{"key":"R27","doi-asserted-by":"crossref","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","volume":"8","author":"Konig","year":"2016","journal-title":"Sci Transl Med"},{"key":"R28","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1600-051X.2009.01496.x","volume":"36","author":"Martinez-Martinez","year":"2009","journal-title":"J Clin Periodontol"},{"key":"R29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s40496-014-0040-9","volume":"2","author":"Payne","year":"2015","journal-title":"Curr Oral health Rep"},{"key":"R30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/154405910608500201","volume":"85","author":"Golub","year":"2006","journal-title":"J Dental Res"},{"key":"R31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1532-3382(12)70051-9","volume":"12","author":"Mays","year":"2012","journal-title":"J Evid Based Dent Pract"},{"key":"R32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/odi.13271","volume":"27","author":"Benli","year":"2021","journal-title":"Oral Dis"},{"key":"R33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10238-021-00728-6","volume":"22","author":"Negrini","year":"2022","journal-title":"Clin Exp Med"},{"key":"R34","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.3390\/ijerph18105238","volume":"18","author":"Benz","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"R35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/2047-783X-16-7-331","volume":"16","author":"Siar","year":"2011","journal-title":"Eur J Med Res"},{"key":"R36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11908-021-00746-1","volume":"23","author":"Zhu","year":"2021","journal-title":"Curr Infect Dis Rep"},{"key":"R37","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/qjmed\/hcs042","volume":"105","author":"Bouaziz","year":"2012","journal-title":"QJM"},{"key":"R38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.clindermatol.2011.01.015","volume":"29","author":"Ramos-e-Silva","year":"2011","journal-title":"Clin Dermatol"},{"key":"R39","first-page":"644","volume":"127","author":"Sahin","year":"2017","journal-title":"Swiss Dent J"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2023195\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T09:06:07Z","timestamp":1706778367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2023195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":39,"journal-issue":{"issue":"1"},"alternative-id":["msc230284"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2023195","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}