{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:23:08Z","timestamp":1777054988579,"version":"3.51.4"},"reference-count":31,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Le syst\u00e8me nerveux ent\u00e9rique (SNE), souvent qualifi\u00e9 de \u00ab\u00a0deuxi\u00e8me cerveau\u00a0\u00bb, joue un r\u00f4le crucial dans la r\u00e9gulation des fonctions digestives. Des dysfonctionnements du SNE sont associ\u00e9s \u00e0 diverses maladies telles que la maladie de Parkinson. Des \u00e9tudes r\u00e9centes sugg\u00e8rent que les troubles digestifs pr\u00e9coces, notamment la constipation chronique, pourraient \u00eatre des signes avant-coureurs de cette maladie neurod\u00e9g\u00e9n\u00e9rative. L\u2019imagerie tridimensionnelle du SNE offre de nouvelles perspectives pour un diagnostic pr\u00e9coce <jats:italic>via<\/jats:italic> notamment l\u2019analyse de biopsies intestinales. Ce nouvel axe de recherche soul\u00e8ve des questions sur l\u2019origine intestinale de la maladie de Parkinson et ouvre la porte \u00e0 une meilleure compr\u00e9hension et une prise en charge anticip\u00e9e de cette maladie.<\/jats:p>","DOI":"10.1051\/medsci\/2024082","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T08:05:37Z","timestamp":1720425937000},"page":"544-549","source":"Crossref","is-referenced-by-count":2,"title":["L\u2019intestin, lanceur d\u2019alerte, dans les pr\u00e9mices de la maladie de Parkinson"],"prefix":"10.1051","volume":"40","author":[{"given":"Doriane","family":"Hazart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malvyne","family":"Rolli-Derkinderen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Delhomme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Derkinderen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Oheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Ricard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1172\/JCI76307","volume":"125","author":"Avetisyan","year":"2015","journal-title":"J Clin Invest"},{"key":"R2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-physiol-021317-121515","volume":"81","author":"Schneider","year":"2019","journal-title":"Annu Rev Physiol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.cell.2023.05.001","volume":"186","author":"Schneider","year":"2023","journal-title":"Cell"},{"key":"R4","doi-asserted-by":"crossref","first-page":"151157","DOI":"10.1016\/j.sempedsurg.2022.151157","volume":"31","author":"Mueller","year":"2022","journal-title":"Semin Pediatr Surg"},{"key":"R5","first-page":"1","volume":"1","author":"Guilhem de Lataillade","year":"2020","journal-title":"Free Neuropathol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2019.08.002","volume":"36","author":"Simon","year":"2020","journal-title":"Clin Geriatr Med"},{"issue":"Suppl 1","key":"R7","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.parkreldis.2017.07.033","volume":"46","author":"Dickson","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"R8","doi-asserted-by":"crossref","first-page":"a024091","DOI":"10.1101\/cshperspect.a024091","volume":"8","author":"Burr\u00e9","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R9","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","volume":"339","author":"Lang","year":"1998","journal-title":"N Engl J Med"},{"key":"R10","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ana.20226","volume":"56","author":"Ross","year":"2004","journal-title":"Ann Neurol"},{"issue":"Suppl 3","key":"R11","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1002\/mds.10146","volume":"17","author":"Pollak","year":"2002","journal-title":"Mov Disord"},{"key":"R12","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"R13","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/mds.27372","volume":"33","author":"Fox","year":"2018","journal-title":"Mov Disord"},{"key":"R14","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/bs.irn.2017.06.003","volume":"134","author":"Stocchi","year":"2017","journal-title":"Int Rev Neurobiol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JPD-161050","volume":"7","author":"Knudsen","year":"2017","journal-title":"J Parkinsons Dis"},{"key":"R16","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","volume":"119","author":"Beach","year":"2010","journal-title":"Acta Neuropathol"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"De Giorgio R, Bianco F, Latorre R, et al. Enteric neuropathies: Yesterday, Today and Tomorrow. In: Brierley S, Costa M, editors. The Enteric Nervous System: 30 Years Later. Advances in Experimental Medicine and Biology. Cham : Springer International Publishing, 2016 : pp. 123\u201333.","DOI":"10.1007\/978-3-319-27592-5_12"},{"key":"R18","doi-asserted-by":"crossref","first-page":"e12728","DOI":"10.1371\/journal.pone.0012728","volume":"5","author":"Lebouvier","year":"2010","journal-title":"PLoS One"},{"key":"R19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00401-012-1040-2","volume":"124","author":"Annerino","year":"2012","journal-title":"Acta Neuropathol"},{"key":"R20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","volume":"396","author":"Braak","year":"2006","journal-title":"Neurosci Lett"},{"key":"R21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fneur.2017.00037","volume":"8","author":"Rietdijk","year":"2017","journal-title":"Front Neurol"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3233\/JPD-212733","volume":"11","author":"Beach","year":"2021","journal-title":"J Parkinsons Dis"},{"key":"R23","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/archneur.63.4.584","volume":"63","author":"Greffard","year":"2006","journal-title":"Arch Neurol"},{"key":"R24","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3233\/JPD-230206","volume":"13","author":"Kulcsarova","year":"2023","journal-title":"J Parkinsons Dis"},{"key":"R25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3810\/hp.1999.07.153","volume":"34","author":"Gershon","year":"1999","journal-title":"Hosp Pract (1995)"},{"key":"R26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neures.2019.02.004","volume":"151","author":"Motegi","year":"2020","journal-title":"Neurosci Res"},{"key":"R27","doi-asserted-by":"crossref","first-page":"1070062","DOI":"10.3389\/fnana.2022.1070062","volume":"16","author":"Hazart","year":"2022","journal-title":"Front Neuroanat"},{"key":"R28","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1073\/pnas.0832308100","volume":"100","author":"Zipfel","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.2321027","volume":"248","author":"Denk","year":"1990","journal-title":"Science"},{"key":"R30","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nmeth818","volume":"2","author":"Helmchen","year":"2005","journal-title":"Nat Methods"},{"key":"R31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnana.2019.00077","volume":"13","author":"Rakotoson","year":"2019","journal-title":"Front Neuroanat"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2024082\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T08:09:11Z","timestamp":1720426151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2024082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":31,"journal-issue":{"issue":"6-7"},"alternative-id":["msc240047"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2024082","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]}}}