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Dans les cardiomyocytes, de multiples isoformes de PDE, aux propri\u00e9t\u00e9s enzymatiques et aux localisations subcellulaires diff\u00e9rentes, r\u00e9gulent localement les niveaux de nucl\u00e9otides cycliques et les fonctions cellulaires associ\u00e9es. Cette organisation est fortement perturb\u00e9e au cours de l\u2019hypertrophie et de l\u2019insuffisance cardiaque \u00e0 fraction d\u2019\u00e9jection r\u00e9duite (IC), ce qui peut contribuer \u00e0 la progression de la maladie. Sur le plan clinique, l\u2019inhibition des PDE a \u00e9t\u00e9 consid\u00e9r\u00e9e comme une approche prometteuse pour compenser la d\u00e9sensibilisation aux cat\u00e9cholamines qui accompagne l\u2019IC. Bien que des inhibiteurs de la PDE3, tels que la milrinone ou l\u2019\u00e9noximone, puissent \u00eatre utilis\u00e9s cliniquement pour am\u00e9liorer la fonction systolique et soulager les sympt\u00f4mes de l\u2019IC aigu\u00eb, leur utilisation chronique s\u2019est av\u00e9r\u00e9e pr\u00e9judiciable. D\u2019autres PDE, telles que les PDE1, PDE2, PDE4, PDE5, PDE9 et PDE10, sont apparues comme de nouvelles cibles potentielles pour le traitement de l\u2019IC, chacune ayant un r\u00f4le unique dans les voies de signalisation locales des nucl\u00e9otides cycliques. Dans cette revue, nous d\u00e9crivons la signalisation de l\u2019AMPc et du GMPc dans les cardiomyocytes et pr\u00e9sentons les diff\u00e9rentes familles de PDE exprim\u00e9es dans le c\u0153ur ainsi que leurs modifications dans l\u2019hypertrophie cardiaque pathologique et dans l\u2019IC. Nous \u00e9valuons \u00e9galement les r\u00e9sultats issus de mod\u00e8les pr\u00e9cliniques ainsi que les donn\u00e9es cliniques indiquant l\u2019utilisation d\u2019inhibiteurs ou d\u2019activateurs de PDE sp\u00e9cifiques qui pourraient avoir un potentiel th\u00e9rapeutique dans l\u2019IC.<\/jats:p>","DOI":"10.1051\/medsci\/2024083","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T08:05:37Z","timestamp":1720425937000},"page":"534-543","source":"Crossref","is-referenced-by-count":0,"title":["Les phosphodiest\u00e9rases des\u00a0nucl\u00e9otides 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