{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:59:55Z","timestamp":1790845195694,"version":"4.1.0"},"reference-count":40,"publisher":"EDP Sciences","issue":"8-9","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"ANR","award":["ANR_23_CE14_0012 Heterosex"],"award-info":[{"award-number":["ANR_23_CE14_0012 Heterosex"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Le sexe de l\u2019embryon est d\u00e9cid\u00e9 au moment de la f\u00e9condation par la transmission paternelle du chromosome sexuel X ou Y, tandis que la m\u00e8re fournit un de ses deux chromosomes X. La diff\u00e9renciation sexuelle d\u00e9bute par le processus de d\u00e9termination du sexe, qui va permettre le d\u00e9veloppement de l\u2019\u00e9bauche gonadique soit en testicule, chez l\u2019embryon XY, soit en ovaire, chez l\u2019embryon XX. Le g\u00e8ne <jats:italic>Sry<\/jats:italic>, localis\u00e9 sur le chromosome Y, n\u00e9cessaire et suffisant pour induire le programme de d\u00e9veloppement masculin, a \u00e9t\u00e9 d\u00e9couvert en 1990, et la communaut\u00e9 scientifique pensait alors que les autres g\u00e8nes impliqu\u00e9s dans le processus de d\u00e9termination du sexe seraient rapidement identifi\u00e9s. Il aura cependant fallu plus de 30 ans pour identifier le facteur d\u00e9terminant la diff\u00e9renciation ovarienne, une isoforme de WT1 appel\u00e9e -KTS. Cette prot\u00e9ine est n\u00e9cessaire pour induire le d\u00e9veloppement de l\u2019ovaire chez les souris XX, et peut emp\u00eacher le d\u00e9veloppement masculin lorsqu\u2019elle est activ\u00e9e pr\u00e9matur\u00e9ment chez les embryons XY. L\u2019isoforme -KTS de WT1 agissant tr\u00e8s t\u00f4t au cours du d\u00e9veloppement, sa d\u00e9couverte ouvre de nouvelles perspectives de recherche sur le d\u00e9veloppement ovarien et permettra de mieux comprendre les r\u00e9seaux de g\u00e8nes impliqu\u00e9s dans certaines alt\u00e9rations du d\u00e9veloppement du sexe.<\/jats:p>","DOI":"10.1051\/medsci\/2024095","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T11:46:55Z","timestamp":1726832815000},"page":"627-633","source":"Crossref","is-referenced-by-count":2,"title":["D\u00e9termination du sexe"],"prefix":"10.1051","volume":"40","author":[{"given":"\u00c9lodie","family":"Gr\u00e9goire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-C\u00e9cile","family":"De 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