{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T05:19:44Z","timestamp":1731993584006,"version":"3.28.0"},"reference-count":11,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>La myasth\u00e9nie auto-immune de l\u2019enfant a des particularit\u00e9s qui motivent une optimisation de la prise en charge th\u00e9rapeutique. D\u2019une part, le traitement immunosuppresseur recommand\u00e9 en premi\u00e8re intention est la corticoth\u00e9rapie, malgr\u00e9 ses importants effets ind\u00e9sirables sur la croissance staturo-pond\u00e9rale, le comportement, le d\u00e9veloppement osseux, etc. D\u2019autre part, faute d\u2019essais cliniques chez l\u2019enfant, la place des nouvelles th\u00e9rapeutiques immunosuppressives reste mal d\u00e9finie. Le rituximab est l\u2019immunosuppresseur non st\u00e9ro\u00efdien le plus utilis\u00e9 en France dans la myasth\u00e9nie auto-immune juv\u00e9nile. Son utilisation, sans uniformisation des pratiques ni suivi de l\u2019efficacit\u00e9 et de sa s\u00e9curit\u00e9, reste non consensuelle. L\u2019objet de ce travail est de proposer une nouvelle place du traitement par rituximab dans la prise en charge de la myasth\u00e9nie auto-immune de l\u2019enfant.<\/jats:p>","DOI":"10.1051\/medsci\/2024132","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T08:51:13Z","timestamp":1731919873000},"page":"22-25","source":"Crossref","is-referenced-by-count":0,"special_numbering":"Hors s\u00e9rie n\u00b0 1","title":["Int\u00e9r\u00eat du traitement par rituximab dans la myasth\u00e9nie auto-immune de 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