{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:37:04Z","timestamp":1778996224893,"version":"3.51.4"},"reference-count":17,"publisher":"EDP Sciences","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/www.edpsciences.org\/en\/authors\/copyright-and-licensing"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Par leur activit\u00e9 myog\u00e9nique, les cellules souches musculaires (CSM) adultes sont cruciales pour la r\u00e9g\u00e9n\u00e9ration du muscle stri\u00e9 squelettique. Apr\u00e8s activation, elles prolif\u00e8rent, se diff\u00e9rencient puis fusionnent pour r\u00e9parer ou former de nouvelles myofibres. Leur progression au cours de la myogen\u00e8se n\u00e9cessite une r\u00e9gulation complexe faisant intervenir plusieurs acteurs tels que le m\u00e9tabolisme, notamment via la kinase AMPK. Cette prot\u00e9ine r\u00e9gule l\u2019auto-renouvellement et l\u2019accr\u00e9tion myonucl\u00e9aire des CSM apr\u00e8s une l\u00e9sion aigu\u00eb du muscle stri\u00e9 squelettique ou en r\u00e9ponse \u00e0 la contraction musculaire. Cependant, dans un contexte de dystrophie telle que la myopathie de Duchenne (DMD), la capacit\u00e9 de r\u00e9g\u00e9n\u00e9ration des CSM est r\u00e9duite, probablement \u00e0 cause d\u2019une prolif\u00e9ration accrue au d\u00e9triment de leur diff\u00e9renciation. Nous nous int\u00e9ressons ici au potentiel du m\u00e9tabolisme \u00e0 r\u00e9guler l\u2019activit\u00e9 myog\u00e9nique des CSM dans la DMD, par l\u2019interm\u00e9diaire de la kinase AMPK.<\/jats:p>","DOI":"10.1051\/medsci\/2024133","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T08:51:13Z","timestamp":1731919873000},"page":"60-63","source":"Crossref","is-referenced-by-count":1,"special_numbering":"Hors s\u00e9rie n\u00b0 1","title":["Cellules souches musculaires et m\u00e9tabolisme dans la dystrophie musculaire de Duchenne, focus sur la kinase 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