{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:12:17Z","timestamp":1785363137452,"version":"3.55.0"},"reference-count":86,"publisher":"EDP Sciences","issue":"3","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>La dengue est une maladie virale transmise par les moustiques du genre <jats:italic>Aedes<\/jats:italic>, dont l\u2019incidence et l\u2019aire de r\u00e9partition sont en constante augmentation depuis les derni\u00e8res d\u00e9cennies. Causant des fi\u00e8vres h\u00e9morragiques dans les cas graves, elle touche principalement les zones tropicales et subtropicales du globe, et menace de s\u2019\u00e9tendre \u00e0 de nouvelles zones g\u00e9ographiques. Il n\u2019existe actuellement aucun traitement sp\u00e9cifique contre la dengue et, du fait de sa physiopathologie complexe et de l\u2019existence de quatre s\u00e9rotypes viraux distincts mais \u00e9troitement apparent\u00e9s, c\u2019est une maladie pour laquelle l\u2019\u00e9laboration d\u2019un vaccin est un vrai d\u00e9fi. Seuls quelques vaccins sont actuellement commercialis\u00e9s ou en cours de d\u00e9veloppement. Cependant, leur utilisation est soumise \u00e0 certaines restrictions. Il est donc n\u00e9cessaire de poursuivre la recherche sur de nouveaux vaccins et d\u2019identifier de nouvelles mol\u00e9cules \u00e0 activit\u00e9s antivirales pour all\u00e9ger le fardeau de sant\u00e9 publique et \u00e9conomique que repr\u00e9sente cette maladie dans les zones d\u2019end\u00e9mie.<\/jats:p>","DOI":"10.1051\/medsci\/2025025","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T08:59:41Z","timestamp":1742547581000},"page":"260-272","source":"Crossref","is-referenced-by-count":2,"title":["Traitements et vaccins contre la dengue"],"prefix":"10.1051","volume":"41","author":[{"given":"Lazare","family":"Br\u00e9zillon-Dubus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Bella","family":"Failloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"250","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1051\/medsci\/2025009","volume":"41","author":"Dupuis","year":"2025","journal-title":"Med Sci (Paris)"},{"key":"R2","doi-asserted-by":"crossref","first-page":"16055","DOI":"10.1038\/nrdp.2016.55","volume":"2","author":"Guzman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"R3","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.vaccine.2018.09.063","volume":"37","year":"2019","journal-title":"Vaccine"},{"key":"R4","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1051\/medsci\/2024116","volume":"40","author":"Despr\u00e8s","year":"2024","journal-title":"Med Sci (Paris)"},{"key":"R5","unstructured":"Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva : World Health Organization, 2009."},{"key":"R6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/v12080829","volume":"12","author":"Harapan","year":"2020","journal-title":"Viruses"},{"key":"R7","first-page":"6115","volume":"111","author":"Correction for Messer","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.jiph.2023.08.001","volume":"16","author":"Khan","year":"2023","journal-title":"J Infect Publ Health"},{"key":"R9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1051\/medsci\/2012281005","volume":"28","author":"Meier","year":"2012","journal-title":"Med Sci (Paris)"},{"key":"R10","doi-asserted-by":"crossref","first-page":"1200195","DOI":"10.3389\/fimmu.2023.1200195","volume":"14","author":"Sarker","year":"2023","journal-title":"Front Immunol"},{"key":"R11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/01.qco.0000244047.31135.fa","volume":"19","author":"Green","year":"2006","journal-title":"Curr Opin Infect Dis"},{"key":"R12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0140-6736(23)02576-X","volume":"403","author":"Paz-Bailey","year":"2024","journal-title":"Lancet"},{"key":"R13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00284-020-02284-w","volume":"78","author":"Bhatt","year":"2021","journal-title":"Curr Microbiol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.1073\/pnas.0703498104","volume":"104","author":"Goncalvez","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"R15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2016.06.002","volume":"30","author":"Kaptein","year":"2016","journal-title":"Curr Opin Pharmacol"},{"key":"R16","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.2217\/fmb.15.105","volume":"10","author":"Chan","year":"2015","journal-title":"Future Microbiol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/cbdd.12309","volume":"84","author":"Panya","year":"2014","journal-title":"Chem Biol Drug Design"},{"key":"R18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1743-422X-2-49","volume":"2","author":"Hrobowski","year":"2005","journal-title":"Virology"},{"key":"R19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/cb500640t","volume":"10","author":"Faustino","year":"2015","journal-title":"ACS Chem Biol"},{"key":"R20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.antiviral.2018.04.019","volume":"155","author":"Smith","year":"2018","journal-title":"Antiviral Res"},{"key":"R21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2015.03.014","volume":"118","author":"Luo","year":"2015","journal-title":"Antiviral Res"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/jac\/dks147","volume":"67","author":"Mastrangelo","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"R23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bbrc.2014.09.113","volume":"453","author":"Basavannacharya","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"R24","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.antiviral.2009.12.011","volume":"85","author":"Noble","year":"2010","journal-title":"Antiviral Res"},{"key":"R25","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.2335168100","volume":"100","author":"Mu\u00f1oz-Jord\u00e1n","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"R26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/rmv.1835","volume":"25","author":"Zmurko","year":"2015","journal-title":"Rev Med Virol"},{"key":"R27","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/AAC.02462-15","volume":"60","author":"Cleef","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"R28","doi-asserted-by":"crossref","first-page":"eabb2181","DOI":"10.1126\/scitranslmed.abb2181","volume":"13","author":"Moquin","year":"2021","journal-title":"Sci Trans Med"},{"key":"R29","doi-asserted-by":"crossref","first-page":"11183","DOI":"10.1128\/JVI.05468-11","volume":"85","author":"Xie","year":"2011","journal-title":"J Virol"},{"key":"R30","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41586-023-05790-6","volume":"615","author":"Goethals","year":"2023","journal-title":"Nature"},{"key":"R31","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41586-021-03990-6","volume":"598","author":"Kaptein","year":"2021","journal-title":"Nature"},{"key":"R32","doi-asserted-by":"crossref","first-page":"105348","DOI":"10.1016\/j.antiviral.2022.105348","volume":"203","author":"Liu","year":"2022","journal-title":"Antiviral Res"},{"key":"R33","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.3390\/molecules26113118","volume":"26","author":"Panya","year":"2021","journal-title":"Molecules"},{"key":"R34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.antiviral.2015.04.010","volume":"119","author":"Lim","year":"2015","journal-title":"Antiviral Res"},{"key":"R35","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/cells11040730","volume":"11","author":"Yang","year":"2022","journal-title":"Cells"},{"key":"R36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nrd4010","volume":"12","author":"Jordheim","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"R37","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1128\/JVI.02283-06","volume":"81","author":"Yap","year":"2007","journal-title":"J Virol"},{"key":"R38","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1261\/rna.1978610","volume":"16","author":"Aspden","year":"2010","journal-title":"RNA"},{"key":"R39","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1517\/17425255.2012.680885","volume":"8","author":"Koczor","year":"2012","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"R40","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/00002030-199814000-00004","volume":"12","author":"Brinkman","year":"1998","journal-title":"AIDS"},{"key":"R41","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1128\/JVI.00045-13","volume":"87","author":"Noble","year":"2013","journal-title":"J Virol"},{"key":"R42","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1021\/acs.jmedchem.6b00143","volume":"59","author":"Yokokawa","year":"2016","journal-title":"J Med Chem"},{"key":"R43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0264-410X(03)00533-4","volume":"22","author":"DeRoeck","year":"2003","journal-title":"Vaccine"},{"key":"R44","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.3390\/v3122374","volume":"3","author":"Wahala","year":"2011","journal-title":"Viruses"},{"key":"R45","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.3390\/v2122649","volume":"2","author":"Guzman","year":"2010","journal-title":"Viruses"},{"key":"R46","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/infdis\/174.6.1176","volume":"174","author":"Putnak","year":"1996","journal-title":"J Infect Dis"},{"key":"R47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.4269\/ajtmh.1996.55.504","volume":"55","author":"Putnak","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"R48","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1016\/j.vaccine.2005.03.042","volume":"23","author":"Robert Putnak","year":"2005","journal-title":"Vaccine"},{"key":"R49","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.virol.2009.10.023","volume":"396","author":"Simmons","year":"2010","journal-title":"Virology"},{"key":"R50","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.vaccine.2010.01.022","volume":"28","author":"Clements","year":"2010","journal-title":"Vaccine"},{"key":"R51","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.vaccine.2015.06.067","volume":"33","author":"Govindarajan","year":"2015","journal-title":"Vaccine"},{"key":"R52","doi-asserted-by":"crossref","unstructured":"Shukla R, Ramasamy V, Shanmugam RK, et al. Antibody-dependent enhancement: a challenge for developing a safe Dengue vaccine. Front Cell Infect Microbiol 2020 ; 10.","DOI":"10.3389\/fcimb.2020.572681"},{"key":"R53","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0264-410X(97)00215-6","volume":"15","author":"Kochel","year":"1997","journal-title":"Vaccine"},{"key":"R54","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1016\/S0264-410X(00)00105-5","volume":"18","author":"Kochel","year":"2000","journal-title":"Vaccine"},{"key":"R55","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.vaccine.2010.11.050","volume":"29","author":"Beckett","year":"2011","journal-title":"Vaccine"},{"key":"R56","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4269\/ajtmh.17-0416","volume":"98","author":"Danko","year":"2018","journal-title":"The American JTrop Med Hyg"},{"key":"R57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd.2017.243","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"R58","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1051\/medsci\/2024002","volume":"40","author":"Dieu-Nosjean","year":"2024","journal-title":"Med Sci (Paris)"},{"key":"R59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.addr.2020.12.014","volume":"170","author":"Kim","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"R60","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1051\/medsci\/2024079","volume":"40","author":"Pitard","year":"2024","journal-title":"Med Sci (Paris)"},{"key":"R61","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3389\/fimmu.2019.01424","volume":"10","author":"Roth","year":"2019","journal-title":"Front Immunol"},{"key":"R62","doi-asserted-by":"crossref","first-page":"e02482","DOI":"10.1128\/JVI.02482-20","volume":"95","author":"Wollner","year":"2021","journal-title":"J Virol"},{"key":"R63","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.3390\/ijms18091957","volume":"18","author":"Chen","year":"2017","journal-title":"Int J Mol Sci"},{"key":"R64","doi-asserted-by":"crossref","first-page":"e21658","DOI":"10.1371\/journal.pone.0021658","volume":"6","author":"Alen","year":"2011","journal-title":"PLoS One"},{"key":"R65","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.antiviral.2018.04.018","volume":"155","author":"Cui","year":"2018","journal-title":"Antiviral Res"},{"key":"R66","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ijbiomac.2012.05.028","volume":"51","author":"Pujol","year":"2012","journal-title":"Int J Biol Macromol"},{"key":"R67","doi-asserted-by":"crossref","first-page":"170797","DOI":"10.1016\/j.peptides.2022.170797","volume":"153","author":"Recalde-Reyes","year":"2022","journal-title":"Peptides"},{"key":"R68","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/cbdd.12576","volume":"86","author":"Panya","year":"2015","journal-title":"Chem Biol Drug Design"},{"key":"R69","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.antiviral.2009.09.011","volume":"84","author":"Poh","year":"2009","journal-title":"Antiviral Res"},{"key":"R70","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.antiviral.2009.09.007","volume":"84","author":"Kampmann","year":"2009","journal-title":"Antiviral Res"},{"key":"R71","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/AAC.01148-08","volume":"53","author":"Wang","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"R72","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12985-019-1127-7","volume":"16","author":"Abdul Ahmad","year":"2019","journal-title":"Virology"},{"key":"R73","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1128\/AAC.02251-12","volume":"57","author":"Byrd","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"R74","first-page":"251482","volume":"2012","author":"Rothan","year":"2012","journal-title":"BioMed Res Int"},{"key":"R75","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/1471-2334-12-314","volume":"12","author":"Rothan","year":"2012","journal-title":"BMC Infect Dis"},{"key":"R76","doi-asserted-by":"crossref","first-page":"85938","DOI":"10.1039\/C5RA14469H","volume":"5","author":"Bhakat","year":"2015","journal-title":"RSC Adv"},{"key":"R77","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3851\/IMP1767","volume":"21","author":"Cregar-Hernandez","year":"2011","journal-title":"Antivir Chem Chemother"},{"key":"R78","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1128\/JVI.00855-15","volume":"89","author":"Wang","year":"2015","journal-title":"J Virol"},{"key":"R79","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.antiviral.2016.09.007","volume":"134","author":"Tarantino","year":"2016","journal-title":"Antiviral Res"},{"key":"R80","doi-asserted-by":"crossref","first-page":"e1005737","DOI":"10.1371\/journal.ppat.1005737","volume":"12","author":"Lim","year":"2016","journal-title":"PLoS Pathog"},{"key":"R81","doi-asserted-by":"crossref","first-page":"20435","DOI":"10.1073\/pnas.0907010106","volume":"106","author":"Yin","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"R82","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/infdis\/jis470","volume":"207","author":"Nguyen","year":"2013","journal-title":"J Infect Dis"},{"key":"R83","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4269\/ajtmh.19-0461","volume":"102","author":"Diaz","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"R84","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4269\/ajtmh.16-0634","volume":"96","author":"Schmidt","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"R85","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1016\/j.vaccine.2011.07.021","volume":"29","author":"Coller","year":"2011","journal-title":"Vaccine"},{"key":"R86","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1080\/21645515.2018.1546523","volume":"15","author":"Manoff","year":"2019","journal-title":"Hum Vaccines Immunother"}],"container-title":["m\u00e9decine\/sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2025025\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T09:11:55Z","timestamp":1742548315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medecinesciences.org\/10.1051\/medsci\/2025025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":86,"journal-issue":{"issue":"3"},"alternative-id":["msc240185"],"URL":"https:\/\/doi.org\/10.1051\/medsci\/2025025","relation":{},"ISSN":["0767-0974","1958-5381"],"issn-type":[{"value":"0767-0974","type":"print"},{"value":"1958-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}