{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:01:34Z","timestamp":1745899294278,"version":"3.40.4"},"reference-count":51,"publisher":"EDP Sciences","issue":"4","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Les lymphocytes T CD4 orientent la r\u00e9ponse immunitaire et facilitent les r\u00e9ponses cytotoxiques et humorales, tout en emp\u00eachant la destruction de nos propres tissus par les lymphocytes T les plus auto-r\u00e9actifs. Cependant, \u00e0 la diff\u00e9rence du d\u00e9ficit complet en lymphocytes T CD4, le d\u00e9ficit apparent caus\u00e9 par des mutations au niveau du g\u00e8ne CD4 qui emp\u00eachent son expression, n\u2019entra\u00eene pas de d\u00e9ficit immunitaire combin\u00e9 s\u00e9v\u00e8re chez l\u2019\u00eatre humain. L\u2019absence de la mol\u00e9cule CD4 limite le nombre de clones s\u00e9lectionn\u00e9s dans le thymus sur la base du complexe majeur d\u2019histocompatibilit\u00e9 de type II, mais n\u2019emp\u00eache pas l\u2019acquisition du programme propre aux lymphocytes T auxiliaires leur permettant ainsi de conserver la majorit\u00e9 de leurs capacit\u00e9s effectrices. Cette observation soul\u00e8ve de nouvelles questions sur la fonction des lymphocytes T CD4 et en particulier sur le r\u00f4le intrins\u00e8que de la mol\u00e9cule CD4.<\/jats:p>","DOI":"10.1051\/medsci\/2025048","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:44:56Z","timestamp":1745826296000},"page":"336-345","source":"Crossref","is-referenced-by-count":0,"title":["R\u00f4le des lymphocytes T CD4 dans la r\u00e9ponse immunitaire"],"prefix":"10.1051","volume":"41","author":[{"given":"Hugo","family":"Roux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Lantz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"e20231044","DOI":"10.1084\/jem.20231044","volume":"221","author":"Gu\u00e9rin","year":"2024","journal-title":"J Exp Med"},{"key":"R2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.coisb.2019.10.001","volume":"18","author":"Mora","year":"2019","journal-title":"Curr Op Syst Biol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nature03338","volume":"433","author":"He","year":"2005","journal-title":"Nature"},{"key":"R4","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/ni.1652","volume":"9","author":"Egawa","year":"2008","journal-title":"Nat Immunol"},{"key":"R5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41590-022-01187-1","volume":"23","author":"Shinzawa","year":"2022","journal-title":"Nat Immunol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1126\/science.1910207","volume":"253","author":"Grusby","year":"1991","journal-title":"Science"},{"key":"R7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0092-8674(05)80090-X","volume":"75","author":"Steimle","year":"1993","journal-title":"Cell"},{"key":"R8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2007.07.007","volume":"27","author":"Moon","year":"2007","journal-title":"Immunity"},{"key":"R9","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1084\/jem.20042521","volume":"201","author":"Obst","year":"2005","journal-title":"J Exp Med"},{"key":"R10","doi-asserted-by":"crossref","first-page":"10799","DOI":"10.1073\/pnas.191124098","volume":"98","author":"Wang","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"R11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(88)90053-0","volume":"55","author":"Veillette","year":"1988","journal-title":"Cell"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"M\u00f8rch AM, B\u00e1lint \u0160, Santos AM, et al. 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