{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:56:48Z","timestamp":1773449808979,"version":"3.50.1"},"reference-count":45,"publisher":"EDP Sciences","issue":"6-7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"ANRS MIE - PEPR MIE","award":["ANRS-23-PEPR-MIE 0002 \u2013 DEBS Plague"],"award-info":[{"award-number":["ANRS-23-PEPR-MIE 0002 \u2013 DEBS Plague"]}]},{"name":"ERC Synergy","award":["101118880"],"award-info":[{"award-number":["101118880"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Sci (Paris)"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>La peste, caus\u00e9e par la bact\u00e9rie <jats:italic>Yersinia pestis<\/jats:italic>, demeure une maladie mortelle \u00e0 l\u2019\u00e9chelle mondiale. Ce pathog\u00e8ne est transmis principalement par les puces, dans lesquelles il s\u2019adapte \u00e0 l\u2019environnement hostile de leur tube digestif, s\u2019y multiplie et forme alors un biofilm dense qui obstrue l\u2019entr\u00e9e de sang. Cette obstruction favorise la transmission de la bact\u00e9rie par r\u00e9gurgitation lors d\u2019un repas sanguin. Ce processus repose sur un programme mol\u00e9culaire initi\u00e9 chez le rongeur et prolong\u00e9 chez l\u2019insecte. Dans cette synth\u00e8se, nous d\u00e9crivons l\u2019environnement dans lequel <jats:italic>Y. pestis<\/jats:italic> \u00e9volue pour infecter les puces, ainsi que les modes de transmission et les m\u00e9canismes mol\u00e9culaires impliqu\u00e9s, tout en adoptant une approche critique pour mieux comprendre les interactions entre <jats:italic>Y. pestis<\/jats:italic> et son vecteur, et explorer de nouvelles strat\u00e9gies de lutte contre la propagation de l\u2019agent de la peste.<\/jats:p>","DOI":"10.1051\/medsci\/2025096","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T07:46:26Z","timestamp":1751874386000},"page":"578-584","source":"Crossref","is-referenced-by-count":1,"title":["La peste \u00e0 l\u2019\u00e8re moderne, comprendre la transmission de la bact\u00e9rie <i>Yersinia pestis<\/i> par les puces"],"prefix":"10.1051","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-9691","authenticated-orcid":false,"given":"Florent","family":"Sebbane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Dewitte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Baillez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"250","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"R1","first-page":"457","volume":"9","author":"Pollitzer","year":"1953","journal-title":"Bull World Health Organ"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Yang R, Atkinson S, Chen Z, et al. 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